Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283801372> ?p ?o ?g. }
- W4283801372 abstract "The dorsal horn (DH) of the spinal cord is an important structure involved in the integration of nociceptive messages. Plastic changes in the properties of neuronal networks in the DH underlie the development of analgesia as well as of hyperalgesia and allodynia in acute and chronic pain states. Two key mechanisms are involved in these chronic pain states: increased electrical activities and glutamate release leading to the recruitment of NMDAr and plastic changes in the synaptic inhibition. Although: (1) the balance between excitation and inhibition is known to play a critical role in the spinal network; and (2) plastic changes in spinal excitation and inhibition have been studied separately, the relationship between these two mechanisms has not been investigated in detail. In the present work, we addressed the role of NMDA receptors in the modulation of GABAergic synaptic transmission in the DH network. Using tight-seal whole-cell recordings on adult mice DH neurons, we characterized the effect of NMDAr activation on inhibitory synaptic transmission and more especially on the GABAergic one. Our results show that, in a subset of neurons recorded in lamina II, NMDAr activation facilitates spontaneous and miniature GABAergic synaptic transmission with a target specificity on GABAergic interneurons. In contrast, NMDA reduced the mean amplitude of evoked GABAergic IPSCs. These results show that NMDAr modulate GABAergic transmission by a presynaptic mechanism of action. Using a pharmacological approach, we investigated the composition of NMDAr involved in this modulation of GABAergic synaptic transmission. We found that the NMDA-induced facilitation was mediated by the activation of NMDAr containing GluN2C/D subunits. Altogether, our results bring new insights on nociceptive information processing in the spinal cord network and plastic changes in synaptic inhibition that could underlie the development and maintenance of chronic pain." @default.
- W4283801372 created "2022-07-05" @default.
- W4283801372 creator A5009075182 @default.
- W4283801372 creator A5028305193 @default.
- W4283801372 creator A5065263323 @default.
- W4283801372 creator A5071552443 @default.
- W4283801372 creator A5072760094 @default.
- W4283801372 creator A5074952519 @default.
- W4283801372 date "2022-07-04" @default.
- W4283801372 modified "2023-10-13" @default.
- W4283801372 title "Modulation of GABAergic Synaptic Transmission by NMDA Receptors in the Dorsal Horn of the Spinal Cord" @default.
- W4283801372 cites W1516122596 @default.
- W4283801372 cites W1566430653 @default.
- W4283801372 cites W1776642984 @default.
- W4283801372 cites W1799512027 @default.
- W4283801372 cites W1918304474 @default.
- W4283801372 cites W1945096581 @default.
- W4283801372 cites W1967450550 @default.
- W4283801372 cites W1978269241 @default.
- W4283801372 cites W1981685682 @default.
- W4283801372 cites W1988059170 @default.
- W4283801372 cites W1989685766 @default.
- W4283801372 cites W1994204256 @default.
- W4283801372 cites W1996698149 @default.
- W4283801372 cites W2001558837 @default.
- W4283801372 cites W2009065017 @default.
- W4283801372 cites W2016556575 @default.
- W4283801372 cites W2016940759 @default.
- W4283801372 cites W2024380057 @default.
- W4283801372 cites W2042017476 @default.
- W4283801372 cites W2044124598 @default.
- W4283801372 cites W2045927851 @default.
- W4283801372 cites W2046263515 @default.
- W4283801372 cites W2047615113 @default.
- W4283801372 cites W2048869899 @default.
- W4283801372 cites W2063010663 @default.
- W4283801372 cites W2069918674 @default.
- W4283801372 cites W2072553414 @default.
- W4283801372 cites W2092085208 @default.
- W4283801372 cites W2101477554 @default.
- W4283801372 cites W2110107835 @default.
- W4283801372 cites W2115487032 @default.
- W4283801372 cites W2116064885 @default.
- W4283801372 cites W2122201711 @default.
- W4283801372 cites W2132915433 @default.
- W4283801372 cites W2133316133 @default.
- W4283801372 cites W2153747443 @default.
- W4283801372 cites W2155524482 @default.
- W4283801372 cites W2162105248 @default.
- W4283801372 cites W2513008873 @default.
- W4283801372 cites W2518391502 @default.
- W4283801372 cites W266709567 @default.
- W4283801372 cites W2751185950 @default.
- W4283801372 cites W2761921473 @default.
- W4283801372 cites W2794340861 @default.
- W4283801372 cites W2917093803 @default.
- W4283801372 cites W2972607117 @default.
- W4283801372 cites W3124100567 @default.
- W4283801372 cites W3197939516 @default.
- W4283801372 doi "https://doi.org/10.3389/fnmol.2022.903087" @default.
- W4283801372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35860500" @default.
- W4283801372 hasPublicationYear "2022" @default.
- W4283801372 type Work @default.
- W4283801372 citedByCount "2" @default.
- W4283801372 countsByYear W42838013722022 @default.
- W4283801372 countsByYear W42838013722023 @default.
- W4283801372 crossrefType "journal-article" @default.
- W4283801372 hasAuthorship W4283801372A5009075182 @default.
- W4283801372 hasAuthorship W4283801372A5028305193 @default.
- W4283801372 hasAuthorship W4283801372A5065263323 @default.
- W4283801372 hasAuthorship W4283801372A5071552443 @default.
- W4283801372 hasAuthorship W4283801372A5072760094 @default.
- W4283801372 hasAuthorship W4283801372A5074952519 @default.
- W4283801372 hasBestOaLocation W42838013721 @default.
- W4283801372 hasConcept C15490471 @default.
- W4283801372 hasConcept C169760540 @default.
- W4283801372 hasConcept C170493617 @default.
- W4283801372 hasConcept C17077164 @default.
- W4283801372 hasConcept C185592680 @default.
- W4283801372 hasConcept C200170125 @default.
- W4283801372 hasConcept C2777883359 @default.
- W4283801372 hasConcept C2779177108 @default.
- W4283801372 hasConcept C2779245659 @default.
- W4283801372 hasConcept C2779296341 @default.
- W4283801372 hasConcept C2780775167 @default.
- W4283801372 hasConcept C55493867 @default.
- W4283801372 hasConcept C61174792 @default.
- W4283801372 hasConcept C67018056 @default.
- W4283801372 hasConcept C86803240 @default.
- W4283801372 hasConcept C98229152 @default.
- W4283801372 hasConceptScore W4283801372C15490471 @default.
- W4283801372 hasConceptScore W4283801372C169760540 @default.
- W4283801372 hasConceptScore W4283801372C170493617 @default.
- W4283801372 hasConceptScore W4283801372C17077164 @default.
- W4283801372 hasConceptScore W4283801372C185592680 @default.
- W4283801372 hasConceptScore W4283801372C200170125 @default.
- W4283801372 hasConceptScore W4283801372C2777883359 @default.
- W4283801372 hasConceptScore W4283801372C2779177108 @default.
- W4283801372 hasConceptScore W4283801372C2779245659 @default.
- W4283801372 hasConceptScore W4283801372C2779296341 @default.