Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283801717> ?p ?o ?g. }
- W4283801717 endingPage "119818" @default.
- W4283801717 startingPage "119818" @default.
- W4283801717 abstract "Heparin, an old but first-line anticoagulant, has been used over a century. It is a heterogeneous, linear, highly sulfated, anionic glycosaminoglycan with a broad distribution in relative molecular weight and charge density. These structural properties allow heparin to selectively interact with multiple proteins, leading to heparin's various pharmacological functions, such as anticoagulant, anti-viral, anti-tumor and anti-inflammatory activities. Clinical data suggest that unfractionated heparin or low molecule weight heparin could decrease mortality in COVID-19 patients with sepsis-induced hypercoagulation through the anticoagulant, anti-viral and anti-inflammatory activities of these drugs. Thus, the non-anticoagulant activity of heparin has again aroused attention. This review highlights recent advances in the preparation of heparin-derived drugs and clinical research on its non-anticoagulant properties over the past decade, to further the development and utilization of these important drugs." @default.
- W4283801717 created "2022-07-05" @default.
- W4283801717 creator A5006597480 @default.
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- W4283801717 creator A5047371223 @default.
- W4283801717 creator A5056210370 @default.
- W4283801717 creator A5069724772 @default.
- W4283801717 creator A5077324920 @default.
- W4283801717 date "2022-11-01" @default.
- W4283801717 modified "2023-10-11" @default.
- W4283801717 title "Heparin: An old drug for new clinical applications" @default.
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