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- W4283802438 endingPage "3271" @default.
- W4283802438 startingPage "3271" @default.
- W4283802438 abstract "Growing evidence points to multiple myeloma (MM) and its stromal microenvironment using several mechanisms to subvert effective immune and anti-tumor responses. Recent advances have uncovered the tumor-stromal cell influence in regulating the immune-microenvironment and have envisioned targeting these suppressive pathways to improve therapeutic outcomes. Nevertheless, some subgroups of patients include those with particularly unfavorable prognoses. Biological stratification can be used to categorize patient-, disease- or therapy-related factors, or alternatively, these biological determinants can be included in a dynamic model that customizes a given treatment to a specific patient. Genetic heterogeneity and current knowledge enforce a systematic and comprehensive bench-to-bedside approach. Given the increasing role of cancer stem cells (CSCs) in better characterizing the pathogenesis of solid and hematological malignancies, disease relapse, and drug resistance, identifying and describing CSCs is of paramount importance in the management of MM. Even though the function of CSCs is well-known in other cancer types, their role in MM remains elusive. With this review, we aim to provide an update on MM homing and resilience in the bone marrow micro milieu. These data are particularly interesting for clinicians facing unmet medical needs while designing novel treatment approaches for MM." @default.
- W4283802438 created "2022-07-05" @default.
- W4283802438 creator A5013957088 @default.
- W4283802438 creator A5051626849 @default.
- W4283802438 creator A5059065322 @default.
- W4283802438 creator A5081396123 @default.
- W4283802438 date "2022-07-04" @default.
- W4283802438 modified "2023-10-18" @default.
- W4283802438 title "The Route of the Malignant Plasma Cell in Its Survival Niche: Exploring “Multiple Myelomas”" @default.
- W4283802438 cites W1082014225 @default.
- W4283802438 cites W1549007983 @default.
- W4283802438 cites W1777794242 @default.
- W4283802438 cites W1966255005 @default.
- W4283802438 cites W1969325964 @default.
- W4283802438 cites W1970521173 @default.
- W4283802438 cites W1971085650 @default.
- W4283802438 cites W1973441809 @default.
- W4283802438 cites W1974656498 @default.
- W4283802438 cites W1977328011 @default.
- W4283802438 cites W1977707370 @default.
- W4283802438 cites W1978643311 @default.
- W4283802438 cites W1982893653 @default.
- W4283802438 cites W1988669425 @default.
- W4283802438 cites W1994581694 @default.
- W4283802438 cites W1999620129 @default.
- W4283802438 cites W2000763979 @default.
- W4283802438 cites W2004300203 @default.
- W4283802438 cites W2006946954 @default.
- W4283802438 cites W2022530652 @default.
- W4283802438 cites W2028682570 @default.
- W4283802438 cites W2039109621 @default.
- W4283802438 cites W2045927984 @default.
- W4283802438 cites W2048603337 @default.
- W4283802438 cites W2050022652 @default.
- W4283802438 cites W2050453122 @default.
- W4283802438 cites W2051372009 @default.
- W4283802438 cites W2052645281 @default.
- W4283802438 cites W2055229514 @default.
- W4283802438 cites W2059066863 @default.
- W4283802438 cites W2059581635 @default.
- W4283802438 cites W2060382742 @default.
- W4283802438 cites W2066800926 @default.
- W4283802438 cites W2067463209 @default.
- W4283802438 cites W2068012172 @default.
- W4283802438 cites W2069359790 @default.
- W4283802438 cites W2076056289 @default.
- W4283802438 cites W2081616641 @default.
- W4283802438 cites W2088037057 @default.
- W4283802438 cites W2090589680 @default.
- W4283802438 cites W2098977954 @default.
- W4283802438 cites W2101035019 @default.
- W4283802438 cites W2102591890 @default.
- W4283802438 cites W2104195581 @default.
- W4283802438 cites W2108495564 @default.
- W4283802438 cites W2119774224 @default.
- W4283802438 cites W2121558833 @default.
- W4283802438 cites W2129942567 @default.
- W4283802438 cites W2130529136 @default.
- W4283802438 cites W2140440734 @default.
- W4283802438 cites W2142473971 @default.
- W4283802438 cites W2144728882 @default.
- W4283802438 cites W2146497768 @default.
- W4283802438 cites W2154244313 @default.
- W4283802438 cites W2154985186 @default.
- W4283802438 cites W2157423336 @default.
- W4283802438 cites W2161604858 @default.
- W4283802438 cites W2163101829 @default.
- W4283802438 cites W2164711235 @default.
- W4283802438 cites W2165608602 @default.
- W4283802438 cites W2171568102 @default.
- W4283802438 cites W2173742377 @default.
- W4283802438 cites W2184192185 @default.
- W4283802438 cites W2194404144 @default.
- W4283802438 cites W2204572831 @default.
- W4283802438 cites W2209836101 @default.
- W4283802438 cites W2229552798 @default.
- W4283802438 cites W2234908256 @default.
- W4283802438 cites W226917763 @default.
- W4283802438 cites W2291176625 @default.
- W4283802438 cites W2292101478 @default.
- W4283802438 cites W2293214575 @default.
- W4283802438 cites W2305579483 @default.
- W4283802438 cites W2307271768 @default.
- W4283802438 cites W2341721659 @default.
- W4283802438 cites W2474873081 @default.
- W4283802438 cites W2489477621 @default.
- W4283802438 cites W2523728529 @default.
- W4283802438 cites W2551754010 @default.
- W4283802438 cites W2560136625 @default.
- W4283802438 cites W2746367132 @default.
- W4283802438 cites W2755285110 @default.
- W4283802438 cites W2761234508 @default.
- W4283802438 cites W2762207309 @default.
- W4283802438 cites W2765884454 @default.
- W4283802438 cites W2766712294 @default.
- W4283802438 cites W2767025366 @default.
- W4283802438 cites W2769954074 @default.
- W4283802438 cites W2791152679 @default.