FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283803285> ?p ?o ?g. }

• W4283803285 endingPage "e452" @default.
• W4283803285 startingPage "e443" @default.
• W4283803285 abstract "Hispanics living in the United States have higher rates of Epidermal Growth Factor Receptor (EGFR) mutations compared with Non-Hispanic Whites. While this higher incidence is like Asian patients living in the United States, the outcomes for Hispanic patients differ. We looked to compare the variances in mutational profiles between Hispanics and Asians in Los Angeles.Three hundred ninety three non-small cell lung cancer (NSCLC) patients treated at Los Angeles County + University of Southern California (LAC + USC) Medical Center and Norris Comprehensive Cancer Center who received comprehensive genomic profiling (CGP) were evaluated from July 2017 to August 2020. CGP was done using tissue biopsies (n = 211) from Caris Life Sciences and liquid biopsies (n = 231) from Guardant Health. Multivariate logistic regression evaluated the role of race between Hispanics and Asians.In the Hispanic cohort (n = 90), 50.0% were male, median age of diagnosis was 62, 54.5% were non-smokers, and 85.5% had adenocarcinoma. In Asians (n = 142), 47.5% were male, median age of diagnosis was 65, 59.6% were non-smokers, and 83.8% had adenocarcinoma. Hispanic patients had greater prevalence of Kirsten rat sarcoma virus (KRAS) mutations (odds ratio [OR] 4.42, 95% confidence interval [95% CI]: 1.63-12.83) and lesser prevalence of EGFR mutations (OR 0.31, 95% CI: 0.16-0.59). There were a greater proportion of Hispanic smokers with KRAS mutations (14/41; 34.1%) than Asian smokers (4/58; 6.9%).We saw a greater percentage of Hispanics with KRAS mutations despite similar smoking percentages along with a greater percentage of Asians with EGFR mutations. This study shows that ethnic and racial backgrounds of the patient can influence the effects of potentially carcinogenic exposures leading to variances of mutation frequency of NSCLC among different ethnicities." @default.
• W4283803285 created "2022-07-05" @default.
• W4283803285 creator A5020075019 @default.
• W4283803285 creator A5027117917 @default.
• W4283803285 creator A5040242676 @default.
• W4283803285 creator A5071469591 @default.
• W4283803285 creator A5086413544 @default.
• W4283803285 date "2022-11-01" @default.
• W4283803285 modified "2023-09-30" @default.
• W4283803285 title "Evaluating Real World Mutational Differences Between Hispanics and Asians in NSCLC at a Large Academic Institution in Los Angeles" @default.
• W4283803285 cites W1154146885 @default.
• W4283803285 cites W117541869 @default.
• W4283803285 cites W1544876451 @default.
• W4283803285 cites W1790427803 @default.
• W4283803285 cites W1828809191 @default.
• W4283803285 cites W1842713165 @default.
• W4283803285 cites W1967255857 @default.
• W4283803285 cites W1967728016 @default.
• W4283803285 cites W1972380802 @default.
• W4283803285 cites W1984005163 @default.
• W4283803285 cites W1984852348 @default.
• W4283803285 cites W1992277751 @default.
• W4283803285 cites W1993020885 @default.
• W4283803285 cites W1994225895 @default.
• W4283803285 cites W2005724920 @default.
• W4283803285 cites W2007718925 @default.
• W4283803285 cites W2009851812 @default.
• W4283803285 cites W2022667262 @default.
• W4283803285 cites W2026470671 @default.
• W4283803285 cites W2028581383 @default.
• W4283803285 cites W2031494655 @default.
• W4283803285 cites W2033955437 @default.
• W4283803285 cites W2040178944 @default.
• W4283803285 cites W2040299716 @default.
• W4283803285 cites W2040636001 @default.
• W4283803285 cites W2050369944 @default.
• W4283803285 cites W2055402151 @default.
• W4283803285 cites W2077582166 @default.
• W4283803285 cites W2089053553 @default.
• W4283803285 cites W2091639070 @default.
• W4283803285 cites W2094903176 @default.
• W4283803285 cites W2101679410 @default.
• W4283803285 cites W2104300284 @default.
• W4283803285 cites W2104748005 @default.
• W4283803285 cites W2108287705 @default.
• W4283803285 cites W2117400940 @default.
• W4283803285 cites W2122319990 @default.
• W4283803285 cites W2129590156 @default.
• W4283803285 cites W2131876608 @default.
• W4283803285 cites W2135595269 @default.
• W4283803285 cites W2139940827 @default.
• W4283803285 cites W2140394766 @default.
• W4283803285 cites W2148174696 @default.
• W4283803285 cites W2154905832 @default.
• W4283803285 cites W2165651085 @default.
• W4283803285 cites W2166749501 @default.
• W4283803285 cites W2168106545 @default.
• W4283803285 cites W2171462710 @default.
• W4283803285 cites W2171597550 @default.
• W4283803285 cites W2475362987 @default.
• W4283803285 cites W2521146636 @default.
• W4283803285 cites W2534193912 @default.
• W4283803285 cites W2567488321 @default.
• W4283803285 cites W2736963305 @default.
• W4283803285 cites W2756811771 @default.
• W4283803285 cites W2772410896 @default.
• W4283803285 cites W2780024648 @default.
• W4283803285 cites W2794844459 @default.
• W4283803285 cites W2805726641 @default.
• W4283803285 cites W2902313845 @default.
• W4283803285 cites W2917245118 @default.
• W4283803285 cites W2924584403 @default.
• W4283803285 cites W2939485990 @default.
• W4283803285 cites W2972404680 @default.
• W4283803285 cites W2988286834 @default.
• W4283803285 cites W3004318979 @default.
• W4283803285 cites W3006608335 @default.
• W4283803285 cites W3081154089 @default.
• W4283803285 cites W3119005666 @default.
• W4283803285 cites W3136354865 @default.
• W4283803285 cites W3158336694 @default.
• W4283803285 doi "https://doi.org/10.1016/j.cllc.2022.06.007" @default.
• W4283803285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35902325" @default.
• W4283803285 hasPublicationYear "2022" @default.
• W4283803285 type Work @default.
• W4283803285 citedByCount "1" @default.
• W4283803285 countsByYear W42838032852023 @default.
• W4283803285 crossrefType "journal-article" @default.
• W4283803285 hasAuthorship W4283803285A5020075019 @default.
• W4283803285 hasAuthorship W4283803285A5027117917 @default.
• W4283803285 hasAuthorship W4283803285A5040242676 @default.
• W4283803285 hasAuthorship W4283803285A5071469591 @default.
• W4283803285 hasAuthorship W4283803285A5086413544 @default.
• W4283803285 hasBestOaLocation W42838032851 @default.
• W4283803285 hasConcept C120665830 @default.
• W4283803285 hasConcept C121332964 @default.
• W4283803285 hasConcept C121608353 @default.
• W4283803285 hasConcept C126322002 @default.

• next