FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283807492> ?p ?o ?g. }

• W4283807492 abstract "Background We showed that Beclin‐1‐dependent autophagy protects the heart in young and adult mice that underwent endotoxemia. Herein, we compared the potential therapeutic effects of Beclin‐1 activating peptide, TB‐peptide, on endotoxemia‐induced cardiac outcomes in young adult and aged mice. We further evaluated lipopolysaccharide (lipopolysaccharide)‐induced and TB‐peptide treatment‐mediated alterations in myocardial metabolism. Methods and Results C57BL/6J mice that were 10 weeks and 24 months old were challenged by lipopolysaccharide using doses at which cardiac dysfunction occurred. Following the treatment of TB‐peptide or control vehicle, heart contractility, circulating cytokines, and myocardial autophagy were evaluated. We detected that TB‐peptide boosted autophagy, attenuated cytokines, and improved cardiac performance in both young and aged mice during endotoxemia. A targeted metabolomics assay was designed to detect a pool of 361 known metabolites, of which 156 were detected in at least 1 of the heart tissue samples. Lipopolysaccharide‐induced impairments were found in glucose and amino acid metabolisms in mice of all ages, and TB‐peptide ameliorated these alterations. However, lipid metabolites were upregulated in the young group but moderately downregulated in the aged by lipopolysaccharide, suggesting an age‐dependent response. TB‐peptide mitigated lipopolysaccharide‐mediated trend of lipids in the young mice but had little effect on the aged. (Study registration: Project DOI: https://doi.org/10.21228/M8K11W ). Conclusions Pharmacological activation of Beclin‐1 by TB‐peptide is cardiac protective in both young and aged population during endotoxemia, suggest a therapeutic potential for sepsis‐induced cardiomyopathy. Metabolomics analysis suggests that an age‐independent protection by TB‐peptide is associated with reprograming of energy production via glucose and amino acid metabolisms." @default.
• W4283807492 created "2022-07-06" @default.
• W4283807492 creator A5002719697 @default.
• W4283807492 creator A5008237675 @default.
• W4283807492 creator A5013222754 @default.
• W4283807492 creator A5023366064 @default.
• W4283807492 creator A5029135951 @default.
• W4283807492 creator A5035032820 @default.
• W4283807492 creator A5039441567 @default.
• W4283807492 creator A5044797313 @default.
• W4283807492 creator A5047200113 @default.
• W4283807492 creator A5047889039 @default.
• W4283807492 creator A5063632511 @default.
• W4283807492 creator A5063838514 @default.
• W4283807492 creator A5080750229 @default.
• W4283807492 creator A5088735073 @default.
• W4283807492 creator A5090207372 @default.
• W4283807492 creator A5090520492 @default.
• W4283807492 date "2022-07-19" @default.
• W4283807492 modified "2023-10-14" @default.
• W4283807492 title "Age‐Independent Cardiac Protection by Pharmacological Activation of Beclin‐1 During Endotoxemia and Its Association With Energy Metabolic Reprograming in Myocardium—A Targeted Metabolomics Study" @default.
• W4283807492 cites W1125737316 @default.
• W4283807492 cites W1504122200 @default.
• W4283807492 cites W1512100404 @default.
• W4283807492 cites W1706150252 @default.
• W4283807492 cites W1780295430 @default.
• W4283807492 cites W1784425676 @default.
• W4283807492 cites W1960974681 @default.
• W4283807492 cites W1965921415 @default.
• W4283807492 cites W1968201338 @default.
• W4283807492 cites W1991900444 @default.
• W4283807492 cites W1995785775 @default.
• W4283807492 cites W2007451226 @default.
• W4283807492 cites W2007505836 @default.
• W4283807492 cites W2009868890 @default.
• W4283807492 cites W2010568558 @default.
• W4283807492 cites W2029175756 @default.
• W4283807492 cites W2039140507 @default.
• W4283807492 cites W2039357236 @default.
• W4283807492 cites W2058533808 @default.
• W4283807492 cites W2061883517 @default.
• W4283807492 cites W2067692987 @default.
• W4283807492 cites W2072138622 @default.
• W4283807492 cites W2081057817 @default.
• W4283807492 cites W2081098333 @default.
• W4283807492 cites W2083073522 @default.
• W4283807492 cites W2098572294 @default.
• W4283807492 cites W2121567540 @default.
• W4283807492 cites W2141151213 @default.
• W4283807492 cites W2146512944 @default.
• W4283807492 cites W2152839556 @default.
• W4283807492 cites W2157115678 @default.
• W4283807492 cites W2159700384 @default.
• W4283807492 cites W2161594732 @default.
• W4283807492 cites W2163632151 @default.
• W4283807492 cites W2169682503 @default.
• W4283807492 cites W2219205942 @default.
• W4283807492 cites W2280404143 @default.
• W4283807492 cites W2290638097 @default.
• W4283807492 cites W2295362613 @default.
• W4283807492 cites W2366061453 @default.
• W4283807492 cites W2473146109 @default.
• W4283807492 cites W2516591253 @default.
• W4283807492 cites W2550412681 @default.
• W4283807492 cites W2601181501 @default.
• W4283807492 cites W2793226488 @default.
• W4283807492 cites W2804257223 @default.
• W4283807492 cites W2806162384 @default.
• W4283807492 cites W2823725159 @default.
• W4283807492 cites W2898685743 @default.
• W4283807492 cites W2931270080 @default.
• W4283807492 cites W2934208435 @default.
• W4283807492 cites W2951837249 @default.
• W4283807492 cites W2979529073 @default.
• W4283807492 cites W3033752439 @default.
• W4283807492 cites W3072232476 @default.
• W4283807492 cites W3164931667 @default.
• W4283807492 cites W3166885405 @default.
• W4283807492 cites W3190631166 @default.
• W4283807492 cites W4238127152 @default.
• W4283807492 cites W4321429534 @default.
• W4283807492 doi "https://doi.org/10.1161/jaha.122.025310" @default.
• W4283807492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35861821" @default.
• W4283807492 hasPublicationYear "2022" @default.
• W4283807492 type Work @default.
• W4283807492 citedByCount "1" @default.
• W4283807492 countsByYear W42838074922023 @default.
• W4283807492 crossrefType "journal-article" @default.
• W4283807492 hasAuthorship W4283807492A5002719697 @default.
• W4283807492 hasAuthorship W4283807492A5008237675 @default.
• W4283807492 hasAuthorship W4283807492A5013222754 @default.
• W4283807492 hasAuthorship W4283807492A5023366064 @default.
• W4283807492 hasAuthorship W4283807492A5029135951 @default.
• W4283807492 hasAuthorship W4283807492A5035032820 @default.
• W4283807492 hasAuthorship W4283807492A5039441567 @default.
• W4283807492 hasAuthorship W4283807492A5044797313 @default.
• W4283807492 hasAuthorship W4283807492A5047200113 @default.
• W4283807492 hasAuthorship W4283807492A5047889039 @default.
• W4283807492 hasAuthorship W4283807492A5063632511 @default.
• W4283807492 hasAuthorship W4283807492A5063838514 @default.

• next