Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283808193> ?p ?o ?g. }
- W4283808193 abstract "Abstract Background Ragweed ( Ambrosia artemisiifolia ) is one of the most important allergen sources, worldwide, causing severe respiratory allergic reactions in late summer and fall, in sensitized patients. Amb a 1 has been considered as the most important allergen in ragweed but 12 ragweed pollen allergens are known. The aim of our study was to investigate IgE reactivity profiles of ragweed allergic patients and to associate them with clinical symptoms. Methods IgE sensitization profiles from clinically well‐characterized ragweed allergic patients ( n = 150) were analyzed using immunoblotted ragweed pollen extract. Immunoblot inhibition experiments were performed with two Amb a 1 isoforms and CCD markers and basophil activation experiments were performed with IgE serum before and after depletion of Amb a 1‐specific IgE. Results By IgE‐immunoblotting 19 different IgE reactivity patterns with and without Amb a 1‐sensitization were found. The majority of patients (>95%) suffered from rhino‐conjunctivitis, around 60% reported asthma‐like symptoms and about 25% had skin reactions. Patients with complex IgE sensitization profiles tended to have more clinical symptoms. Serum with and without Amb a 1‐specific IgE induced basophil activation. Conclusions Ragweed pollen allergic patients exhibit complex IgE reactivity profiles to ragweed allergens including Amb a 1 isoforms and cross‐reactive carbohydrates indicating the importance of Amb a 1 isoforms and additional allergens for diagnosis and allergen‐specific immunotherapy of ragweed allergy." @default.
- W4283808193 created "2022-07-06" @default.
- W4283808193 creator A5018795290 @default.
- W4283808193 creator A5023411125 @default.
- W4283808193 creator A5047622426 @default.
- W4283808193 creator A5050048947 @default.
- W4283808193 creator A5059739307 @default.
- W4283808193 creator A5071207804 @default.
- W4283808193 creator A5072401686 @default.
- W4283808193 creator A5078781592 @default.
- W4283808193 creator A5084339076 @default.
- W4283808193 date "2022-07-01" @default.
- W4283808193 modified "2023-10-01" @default.
- W4283808193 title "Complex IgE sensitization patterns in ragweed allergic patients: Implications for diagnosis and specific immunotherapy" @default.
- W4283808193 cites W113160211 @default.
- W4283808193 cites W1461222686 @default.
- W4283808193 cites W1488976619 @default.
- W4283808193 cites W1518980229 @default.
- W4283808193 cites W1528759976 @default.
- W4283808193 cites W1531317253 @default.
- W4283808193 cites W1873842403 @default.
- W4283808193 cites W1886995266 @default.
- W4283808193 cites W1972929059 @default.
- W4283808193 cites W1989014367 @default.
- W4283808193 cites W1997120806 @default.
- W4283808193 cites W1999138751 @default.
- W4283808193 cites W2011436753 @default.
- W4283808193 cites W2015446675 @default.
- W4283808193 cites W2020545328 @default.
- W4283808193 cites W2037202353 @default.
- W4283808193 cites W2039428280 @default.
- W4283808193 cites W2054627843 @default.
- W4283808193 cites W2060257233 @default.
- W4283808193 cites W2067581591 @default.
- W4283808193 cites W2078483597 @default.
- W4283808193 cites W208386854 @default.
- W4283808193 cites W2088396697 @default.
- W4283808193 cites W2093617862 @default.
- W4283808193 cites W2104289972 @default.
- W4283808193 cites W2111774315 @default.
- W4283808193 cites W2117812405 @default.
- W4283808193 cites W2128058968 @default.
- W4283808193 cites W2138640786 @default.
- W4283808193 cites W2147487353 @default.
- W4283808193 cites W2151575970 @default.
- W4283808193 cites W2316655623 @default.
- W4283808193 cites W2408537307 @default.
- W4283808193 cites W2472611101 @default.
- W4283808193 cites W248829552 @default.
- W4283808193 cites W2510718844 @default.
- W4283808193 cites W2560662790 @default.
- W4283808193 cites W2567417995 @default.
- W4283808193 cites W2610458395 @default.
- W4283808193 cites W2766540519 @default.
- W4283808193 cites W2804258635 @default.
- W4283808193 cites W2884618299 @default.
- W4283808193 cites W2889439914 @default.
- W4283808193 cites W2906154194 @default.
- W4283808193 cites W2907538897 @default.
- W4283808193 cites W2912399441 @default.
- W4283808193 cites W2916610774 @default.
- W4283808193 cites W2945590566 @default.
- W4283808193 cites W2946069264 @default.
- W4283808193 cites W2963999121 @default.
- W4283808193 cites W2999571618 @default.
- W4283808193 cites W3021013573 @default.
- W4283808193 cites W3138241598 @default.
- W4283808193 cites W4283396270 @default.
- W4283808193 cites W53284725 @default.
- W4283808193 cites W86114122 @default.
- W4283808193 cites W9586707 @default.
- W4283808193 doi "https://doi.org/10.1002/clt2.12179" @default.
- W4283808193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35813977" @default.
- W4283808193 hasPublicationYear "2022" @default.
- W4283808193 type Work @default.
- W4283808193 citedByCount "3" @default.
- W4283808193 countsByYear W42838081932023 @default.
- W4283808193 crossrefType "journal-article" @default.
- W4283808193 hasAuthorship W4283808193A5018795290 @default.
- W4283808193 hasAuthorship W4283808193A5023411125 @default.
- W4283808193 hasAuthorship W4283808193A5047622426 @default.
- W4283808193 hasAuthorship W4283808193A5050048947 @default.
- W4283808193 hasAuthorship W4283808193A5059739307 @default.
- W4283808193 hasAuthorship W4283808193A5071207804 @default.
- W4283808193 hasAuthorship W4283808193A5072401686 @default.
- W4283808193 hasAuthorship W4283808193A5078781592 @default.
- W4283808193 hasAuthorship W4283808193A5084339076 @default.
- W4283808193 hasBestOaLocation W42838081933 @default.
- W4283808193 hasConcept C126322002 @default.
- W4283808193 hasConcept C141105273 @default.
- W4283808193 hasConcept C159654299 @default.
- W4283808193 hasConcept C170493617 @default.
- W4283808193 hasConcept C18903297 @default.
- W4283808193 hasConcept C203014093 @default.
- W4283808193 hasConcept C207480886 @default.
- W4283808193 hasConcept C2776217527 @default.
- W4283808193 hasConcept C2777456892 @default.
- W4283808193 hasConcept C2777701055 @default.
- W4283808193 hasConcept C2779174183 @default.
- W4283808193 hasConcept C2779176990 @default.