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- W4283809068 abstract "Curcumin, isolated from turmeric (Curcuma longa L.) is one of the broadly studied phytomolecule owing to its strong antioxidant and anti-inflammatory potential and has been considered a promising therapeutic candidate in a wide range of disorders. Considering, its low bioavailability, different curcumin analogs have been developed to afford desired pharmacokinetic profile and therapeutic outcome in varied pathological states. Several preclinical and clinical studies have indicated that curcumin ameliorates mitochondrial dysfunction, inflammation, oxidative stress apoptosis-mediated neural cell degeneration and could effectively be utilized in the treatment of different neurodegenerative diseases. Hence, in this review, we have summarized key findings of experimental and clinical studies conducted on curcumin and its analogues with special emphasis on molecular pathways, viz. NF-kB, Nrf2-ARE, glial activation, apoptosis, angiogenesis, SOCS/JAK/STAT, PI3K/Akt, ERK1/2 /MyD88 /p38 MAPK, JNK, iNOS/NO, and MMP pathways involved in imparting ameliorative effects in the therapy of neurodegenerative disorders and associated conditions." @default.
- W4283809068 created "2022-07-06" @default.
- W4283809068 creator A5036941731 @default.
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- W4283809068 date "2022-07-04" @default.
- W4283809068 modified "2023-10-06" @default.
- W4283809068 title "Ameliorating potential of curcumin and its analogue in central nervous system disorders and related conditions: A review of molecular pathways" @default.
- W4283809068 cites W1022975193 @default.
- W4283809068 cites W1032629512 @default.
- W4283809068 cites W106969692 @default.
- W4283809068 cites W1413160439 @default.
- W4283809068 cites W1442891870 @default.
- W4283809068 cites W1485603520 @default.
- W4283809068 cites W1506045573 @default.
- W4283809068 cites W1519936974 @default.
- W4283809068 cites W1520204166 @default.
- W4283809068 cites W1535426243 @default.
- W4283809068 cites W1543786573 @default.
- W4283809068 cites W1547957565 @default.
- W4283809068 cites W1548483078 @default.
- W4283809068 cites W1558835554 @default.
- W4283809068 cites W1562818493 @default.
- W4283809068 cites W1563590122 @default.
- W4283809068 cites W1567008338 @default.
- W4283809068 cites W1578872259 @default.
- W4283809068 cites W1581242854 @default.
- W4283809068 cites W1586405889 @default.
- W4283809068 cites W1588188747 @default.
- W4283809068 cites W1593747838 @default.
- W4283809068 cites W1596069616 @default.
- W4283809068 cites W165561446 @default.
- W4283809068 cites W1691644051 @default.
- W4283809068 cites W1754891924 @default.
- W4283809068 cites W1766288982 @default.
- W4283809068 cites W1776526278 @default.
- W4283809068 cites W1928026847 @default.
- W4283809068 cites W1937475214 @default.
- W4283809068 cites W1939106908 @default.
- W4283809068 cites W1948459656 @default.
- W4283809068 cites W1963841078 @default.
- W4283809068 cites W1963947961 @default.
- W4283809068 cites W1967845903 @default.
- W4283809068 cites W1967886692 @default.
- W4283809068 cites W1968152031 @default.
- W4283809068 cites W1968671595 @default.
- W4283809068 cites W1969272044 @default.
- W4283809068 cites W1969691479 @default.
- W4283809068 cites W1970310042 @default.
- W4283809068 cites W1970538568 @default.
- W4283809068 cites W1972179974 @default.
- W4283809068 cites W1974150730 @default.
- W4283809068 cites W1975668586 @default.
- W4283809068 cites W1976630082 @default.
- W4283809068 cites W1977604451 @default.
- W4283809068 cites W1979218557 @default.
- W4283809068 cites W1979734999 @default.
- W4283809068 cites W1980346083 @default.
- W4283809068 cites W1980661152 @default.
- W4283809068 cites W1981448349 @default.
- W4283809068 cites W1982685213 @default.
- W4283809068 cites W1983657484 @default.
- W4283809068 cites W1983866861 @default.
- W4283809068 cites W1983879753 @default.
- W4283809068 cites W1983963285 @default.
- W4283809068 cites W1985049657 @default.
- W4283809068 cites W1985438873 @default.
- W4283809068 cites W1987614608 @default.
- W4283809068 cites W1988492454 @default.
- W4283809068 cites W1989550670 @default.
- W4283809068 cites W1990260730 @default.
- W4283809068 cites W1990950895 @default.
- W4283809068 cites W1991906033 @default.
- W4283809068 cites W1991990496 @default.
- W4283809068 cites W1992222048 @default.
- W4283809068 cites W1992478997 @default.
- W4283809068 cites W1992935683 @default.
- W4283809068 cites W1994264943 @default.
- W4283809068 cites W1994612911 @default.
- W4283809068 cites W1995355260 @default.
- W4283809068 cites W1996017124 @default.
- W4283809068 cites W1997303368 @default.
- W4283809068 cites W1997343243 @default.
- W4283809068 cites W1998000193 @default.
- W4283809068 cites W2001106708 @default.
- W4283809068 cites W2001210466 @default.
- W4283809068 cites W2002737118 @default.
- W4283809068 cites W2002850210 @default.
- W4283809068 cites W2003062523 @default.
- W4283809068 cites W2004750343 @default.
- W4283809068 cites W2004874491 @default.
- W4283809068 cites W2004945782 @default.
- W4283809068 cites W2005085550 @default.
- W4283809068 cites W2006018012 @default.