FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283811580> ?p ?o ?g. }

• W4283811580 abstract "Circular RNAs (circRNAs) are a distinctive type of endogenous non-coding RNAs, and their regulatory roles in neurological disorders have received immense attention. CircRNAs significantly contribute to the regulation of gene expression and progression of neurodegenerative disorders including Alzheimer’s disease (AD). The current study aimed to identify circRNAs as prognostic and potential biomarkers in AD. The differentially expressed circRNAs among subjective cognitive decline, amnestic mild cognitive impairment, and age-matched normal donors were determined through Arraystar Human circRNA Array V2 analysis. The annotations of circRNAs-microRNA interactions were predicted by employing Arraystar’s homemade microRNAs (miRNA) target prediction tool. Bioinformatics analyses comprising gene ontology enrichment, KEGG pathway, and network analysis were conducted. Microarray analysis revealed the 33 upregulated and 11 downregulated differentially expressed circRNAs (FC ≥ 1.5 and p -values ≤ 0.05). The top 10 differentially expressed upregulated and downregulated circRNAs have been chosen for further expression validation through quantitative real-time PCR and subsequently, hsa-circRNA_001481 and hsa_circRNA_000479 were confirmed experimentally. Bioinformatics analyses determined the circRNA-miRNA-mRNA interactions and microRNA response elements to inhibit the expression of miRNAs and mRNA targets. Gene ontology enrichment and KEGG pathways analysis revealed the functional clustering of target mRNAs suggesting the functional verification of these two promising circRNAs. It is concluded that human circRNA_001481 and circRNA_000479 could be utilized as potential biomarkers for the early onset detection of AD and the development of effective therapeutics." @default.
• W4283811580 created "2022-07-06" @default.
• W4283811580 creator A5023639719 @default.
• W4283811580 creator A5040958184 @default.
• W4283811580 creator A5048411184 @default.
• W4283811580 creator A5048869783 @default.
• W4283811580 creator A5070221048 @default.
• W4283811580 creator A5078124312 @default.
• W4283811580 creator A5085386009 @default.
• W4283811580 creator A5090580736 @default.
• W4283811580 date "2022-07-05" @default.
• W4283811580 modified "2023-10-09" @default.
• W4283811580 title "Screening of Human Circular RNAs as Biomarkers for Early Onset Detection of Alzheimer’s Disease" @default.
• W4283811580 cites W1566841623 @default.
• W4283811580 cites W1597194280 @default.
• W4283811580 cites W1770991729 @default.
• W4283811580 cites W1846631206 @default.
• W4283811580 cites W1967791012 @default.
• W4283811580 cites W1991082489 @default.
• W4283811580 cites W2013485286 @default.
• W4283811580 cites W2014821302 @default.
• W4283811580 cites W2017919052 @default.
• W4283811580 cites W2020988957 @default.
• W4283811580 cites W2023139734 @default.
• W4283811580 cites W2029989907 @default.
• W4283811580 cites W2034305079 @default.
• W4283811580 cites W2048505725 @default.
• W4283811580 cites W2054891772 @default.
• W4283811580 cites W2064165694 @default.
• W4283811580 cites W2083381199 @default.
• W4283811580 cites W2095799789 @default.
• W4283811580 cites W2110884132 @default.
• W4283811580 cites W2120456037 @default.
• W4283811580 cites W2126938291 @default.
• W4283811580 cites W2128549339 @default.
• W4283811580 cites W2152719653 @default.
• W4283811580 cites W2158217645 @default.
• W4283811580 cites W2159675211 @default.
• W4283811580 cites W2172312226 @default.
• W4283811580 cites W2284415752 @default.
• W4283811580 cites W2285247593 @default.
• W4283811580 cites W2297957816 @default.
• W4283811580 cites W2306877291 @default.
• W4283811580 cites W2324056313 @default.
• W4283811580 cites W2326363926 @default.
• W4283811580 cites W2409907752 @default.
• W4283811580 cites W2569896510 @default.
• W4283811580 cites W2572160591 @default.
• W4283811580 cites W2605139631 @default.
• W4283811580 cites W2616072553 @default.
• W4283811580 cites W2617715606 @default.
• W4283811580 cites W2734285790 @default.
• W4283811580 cites W2763836527 @default.
• W4283811580 cites W2777388159 @default.
• W4283811580 cites W2782867035 @default.
• W4283811580 cites W2783105462 @default.
• W4283811580 cites W2798054687 @default.
• W4283811580 cites W2803066764 @default.
• W4283811580 cites W2885154462 @default.
• W4283811580 cites W2885229294 @default.
• W4283811580 cites W2892630678 @default.
• W4283811580 cites W2893696675 @default.
• W4283811580 cites W2946332407 @default.
• W4283811580 cites W2946832188 @default.
• W4283811580 cites W2949868877 @default.
• W4283811580 cites W2970358232 @default.
• W4283811580 cites W2972168835 @default.
• W4283811580 cites W2998968185 @default.
• W4283811580 cites W3013108491 @default.
• W4283811580 cites W3045202874 @default.
• W4283811580 cites W3159567489 @default.
• W4283811580 cites W4211139529 @default.
• W4283811580 cites W852879823 @default.
• W4283811580 doi "https://doi.org/10.3389/fnins.2022.878287" @default.
• W4283811580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35864990" @default.
• W4283811580 hasPublicationYear "2022" @default.
• W4283811580 type Work @default.
• W4283811580 citedByCount "1" @default.
• W4283811580 countsByYear W42838115802023 @default.
• W4283811580 crossrefType "journal-article" @default.
• W4283811580 hasAuthorship W4283811580A5023639719 @default.
• W4283811580 hasAuthorship W4283811580A5040958184 @default.
• W4283811580 hasAuthorship W4283811580A5048411184 @default.
• W4283811580 hasAuthorship W4283811580A5048869783 @default.
• W4283811580 hasAuthorship W4283811580A5070221048 @default.
• W4283811580 hasAuthorship W4283811580A5078124312 @default.
• W4283811580 hasAuthorship W4283811580A5085386009 @default.
• W4283811580 hasAuthorship W4283811580A5090580736 @default.
• W4283811580 hasBestOaLocation W42838115801 @default.
• W4283811580 hasConcept C104317684 @default.
• W4283811580 hasConcept C127561419 @default.
• W4283811580 hasConcept C145059251 @default.
• W4283811580 hasConcept C150194340 @default.
• W4283811580 hasConcept C152724338 @default.
• W4283811580 hasConcept C18431079 @default.
• W4283811580 hasConcept C186836561 @default.
• W4283811580 hasConcept C2775893923 @default.
• W4283811580 hasConcept C2987395477 @default.
• W4283811580 hasConcept C54355233 @default.
• W4283811580 hasConcept C60365752 @default.

• next