Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283819325> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4283819325 endingPage "e88" @default.
- W4283819325 startingPage "e78" @default.
- W4283819325 abstract "Abstract The study aimed to investigate the factors affecting the stability of imipenem and cilastatin sodium for injection (IMI/CIL) to improve the quality and stability in IMI/CIL preparation. In this study, the effects of headspace oxygen (HO), water content, particle shape, and particle size on the stability of IMI/CIL were investigated. IMI/CIL was purged with air, premixed oxygen/nitrogen gas (5%/95%), or high-purity nitrogen (99.999%) at 20, 5, or 2% oxygen levels to prepare IMI/CIL with different HO levels. IMI/CIL was stored at 30, 45, and 75% relative humidity for 30 days to prepare IMI/CIL with different water contents. High-performance liquid chromatography method was used for analysis. The results showed that oxygen, water, particle shape, and particle size had significant effects on the stability of IMI/CIL, and free water content is a better predictor of the safety and stability of imipenem and cilastatin sodium than the total water content. The optimization scheme of the above parameters is proposed, which significantly improves the stability of IMI/CIL. This study led to a better understanding of the degradation mechanism of imipenem and cilastatin sodium, and could provide a reference for the selection and control of IMI/CIL process conditions. This study would contribute to the development of IMI/CIL with improved stability." @default.
- W4283819325 created "2022-07-06" @default.
- W4283819325 creator A5001219472 @default.
- W4283819325 creator A5004892215 @default.
- W4283819325 creator A5015760127 @default.
- W4283819325 creator A5023543349 @default.
- W4283819325 creator A5057164670 @default.
- W4283819325 creator A5058225779 @default.
- W4283819325 creator A5064156364 @default.
- W4283819325 creator A5083704337 @default.
- W4283819325 date "2022-06-01" @default.
- W4283819325 modified "2023-09-27" @default.
- W4283819325 title "Effect of Oxygen and Water on the Stability of Imipenem and Cilastatin Sodium for Injection" @default.
- W4283819325 cites W1660780035 @default.
- W4283819325 cites W168483134 @default.
- W4283819325 cites W1998245627 @default.
- W4283819325 cites W2012706507 @default.
- W4283819325 cites W2041118820 @default.
- W4283819325 cites W2052637252 @default.
- W4283819325 cites W2073502936 @default.
- W4283819325 cites W2088445383 @default.
- W4283819325 cites W2127886322 @default.
- W4283819325 cites W2782945584 @default.
- W4283819325 cites W2895127693 @default.
- W4283819325 cites W2947288411 @default.
- W4283819325 cites W3094089747 @default.
- W4283819325 cites W3169349301 @default.
- W4283819325 cites W3186327584 @default.
- W4283819325 doi "https://doi.org/10.1055/s-0042-1750043" @default.
- W4283819325 hasPublicationYear "2022" @default.
- W4283819325 type Work @default.
- W4283819325 citedByCount "0" @default.
- W4283819325 crossrefType "journal-article" @default.
- W4283819325 hasAuthorship W4283819325A5001219472 @default.
- W4283819325 hasAuthorship W4283819325A5004892215 @default.
- W4283819325 hasAuthorship W4283819325A5015760127 @default.
- W4283819325 hasAuthorship W4283819325A5023543349 @default.
- W4283819325 hasAuthorship W4283819325A5057164670 @default.
- W4283819325 hasAuthorship W4283819325A5058225779 @default.
- W4283819325 hasAuthorship W4283819325A5064156364 @default.
- W4283819325 hasAuthorship W4283819325A5083704337 @default.
- W4283819325 hasBestOaLocation W42838193251 @default.
- W4283819325 hasConcept C111368507 @default.
- W4283819325 hasConcept C127313418 @default.
- W4283819325 hasConcept C13965031 @default.
- W4283819325 hasConcept C147789679 @default.
- W4283819325 hasConcept C178790620 @default.
- W4283819325 hasConcept C185592680 @default.
- W4283819325 hasConcept C187530423 @default.
- W4283819325 hasConcept C2777437143 @default.
- W4283819325 hasConcept C2778517922 @default.
- W4283819325 hasConcept C2779631663 @default.
- W4283819325 hasConcept C43617362 @default.
- W4283819325 hasConcept C501593827 @default.
- W4283819325 hasConcept C537181965 @default.
- W4283819325 hasConcept C537208039 @default.
- W4283819325 hasConcept C540031477 @default.
- W4283819325 hasConcept C55493867 @default.
- W4283819325 hasConcept C94665300 @default.
- W4283819325 hasConceptScore W4283819325C111368507 @default.
- W4283819325 hasConceptScore W4283819325C127313418 @default.
- W4283819325 hasConceptScore W4283819325C13965031 @default.
- W4283819325 hasConceptScore W4283819325C147789679 @default.
- W4283819325 hasConceptScore W4283819325C178790620 @default.
- W4283819325 hasConceptScore W4283819325C185592680 @default.
- W4283819325 hasConceptScore W4283819325C187530423 @default.
- W4283819325 hasConceptScore W4283819325C2777437143 @default.
- W4283819325 hasConceptScore W4283819325C2778517922 @default.
- W4283819325 hasConceptScore W4283819325C2779631663 @default.
- W4283819325 hasConceptScore W4283819325C43617362 @default.
- W4283819325 hasConceptScore W4283819325C501593827 @default.
- W4283819325 hasConceptScore W4283819325C537181965 @default.
- W4283819325 hasConceptScore W4283819325C537208039 @default.
- W4283819325 hasConceptScore W4283819325C540031477 @default.
- W4283819325 hasConceptScore W4283819325C55493867 @default.
- W4283819325 hasConceptScore W4283819325C94665300 @default.
- W4283819325 hasIssue "02" @default.
- W4283819325 hasLocation W42838193251 @default.
- W4283819325 hasLocation W42838193252 @default.
- W4283819325 hasOpenAccess W4283819325 @default.
- W4283819325 hasPrimaryLocation W42838193251 @default.
- W4283819325 hasRelatedWork W114962087 @default.
- W4283819325 hasRelatedWork W1970319043 @default.
- W4283819325 hasRelatedWork W2003623373 @default.
- W4283819325 hasRelatedWork W2061936672 @default.
- W4283819325 hasRelatedWork W2114496882 @default.
- W4283819325 hasRelatedWork W2117639658 @default.
- W4283819325 hasRelatedWork W2493600594 @default.
- W4283819325 hasRelatedWork W2751854910 @default.
- W4283819325 hasRelatedWork W2916118991 @default.
- W4283819325 hasRelatedWork W76189171 @default.
- W4283819325 hasVolume "04" @default.
- W4283819325 isParatext "false" @default.
- W4283819325 isRetracted "false" @default.
- W4283819325 workType "article" @default.