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- W4283825906 abstract "Mitochondria provide neurons not only energy as ATP to keep them growing, proliferating and developing, but they also control apoptosis. Due to their high bioenergetic demand, neurons which are highly specific terminally differentiated cells, essentially depend on mitochondria. Defective mitochondrial function is thus related to numerous age-linked neurodegenerative ailments like Alzheimer's disease (AD), in which the build-up of impaired and malfunctioning mitochondria has been identified as a primary sign, paying to disease development. Mitophagy, selective autophagy, is a key mitochondrial quality control system that helps neurons to stay healthy and functional by removing undesired and damaged mitochondria. Dysfunctional mitochondria and dysregulated mitophagy have been closely associated with the onset of ADs. Various proteins associated with mitophagy were found to be altered in AD. Therapeutic strategies focusing on the restoration of mitophagy capabilities could be utilized to strike the development of AD pathogenesis. We summarize the mechanism and role of mitophagy in the onset and advancement of AD, in the quality control mechanism of mitochondria, the consequences of dysfunctional mitophagy in AD, and potential therapeutic approaches involving mitophagy modulation in AD. To develop new therapeutic methods, a better knowledge of the function of mitophagy in the pathophysiology of AD is required." @default.
- W4283825906 created "2022-07-07" @default.
- W4283825906 creator A5039911847 @default.
- W4283825906 creator A5045375940 @default.
- W4283825906 creator A5060726047 @default.
- W4283825906 creator A5079405785 @default.
- W4283825906 date "2022-07-06" @default.
- W4283825906 modified "2023-10-02" @default.
- W4283825906 title "Mitophagy: An Emergence of New Player in Alzheimer’s Disease" @default.
- W4283825906 cites W1523693806 @default.
- W4283825906 cites W1780178978 @default.
- W4283825906 cites W1977930505 @default.
- W4283825906 cites W1980054636 @default.
- W4283825906 cites W1984911164 @default.
- W4283825906 cites W1992947862 @default.
- W4283825906 cites W1999532278 @default.
- W4283825906 cites W2013642338 @default.
- W4283825906 cites W2018659142 @default.
- W4283825906 cites W2034326623 @default.
- W4283825906 cites W2039392338 @default.
- W4283825906 cites W2040414192 @default.
- W4283825906 cites W2043291430 @default.
- W4283825906 cites W2049999907 @default.
- W4283825906 cites W2053635103 @default.
- W4283825906 cites W2089141103 @default.
- W4283825906 cites W2108113014 @default.
- W4283825906 cites W2112329697 @default.
- W4283825906 cites W2117217282 @default.
- W4283825906 cites W2118649927 @default.
- W4283825906 cites W2122508074 @default.
- W4283825906 cites W2127440157 @default.
- W4283825906 cites W2131415852 @default.
- W4283825906 cites W2147452863 @default.
- W4283825906 cites W2164945122 @default.
- W4283825906 cites W2168681379 @default.
- W4283825906 cites W2172204522 @default.
- W4283825906 cites W2198512561 @default.
- W4283825906 cites W2221731984 @default.
- W4283825906 cites W2231591590 @default.
- W4283825906 cites W2284984697 @default.
- W4283825906 cites W2290400089 @default.
- W4283825906 cites W2293737369 @default.
- W4283825906 cites W2296494566 @default.
- W4283825906 cites W2471742367 @default.
- W4283825906 cites W2513964174 @default.
- W4283825906 cites W2516989289 @default.
- W4283825906 cites W2553689505 @default.
- W4283825906 cites W2563511305 @default.
- W4283825906 cites W2586594127 @default.
- W4283825906 cites W2587843731 @default.
- W4283825906 cites W2589496748 @default.
- W4283825906 cites W2605408542 @default.
- W4283825906 cites W2737962827 @default.
- W4283825906 cites W2743254891 @default.
- W4283825906 cites W2755721896 @default.
- W4283825906 cites W2767859551 @default.
- W4283825906 cites W2793585092 @default.
- W4283825906 cites W2795684416 @default.
- W4283825906 cites W2799640787 @default.
- W4283825906 cites W2811212358 @default.
- W4283825906 cites W2887997888 @default.
- W4283825906 cites W2903973081 @default.
- W4283825906 cites W2911248861 @default.
- W4283825906 cites W2912183228 @default.
- W4283825906 cites W2917816476 @default.
- W4283825906 cites W2921919999 @default.
- W4283825906 cites W2923748671 @default.
- W4283825906 cites W2924469223 @default.
- W4283825906 cites W2945779890 @default.
- W4283825906 cites W2945917308 @default.
- W4283825906 cites W2949302450 @default.
- W4283825906 cites W2951163658 @default.
- W4283825906 cites W2964527509 @default.
- W4283825906 cites W2972368830 @default.
- W4283825906 cites W2990428942 @default.
- W4283825906 cites W2993701748 @default.
- W4283825906 cites W2999049897 @default.
- W4283825906 cites W2999771085 @default.
- W4283825906 cites W3004139737 @default.
- W4283825906 cites W3005805254 @default.
- W4283825906 cites W3029634315 @default.
- W4283825906 cites W3033798323 @default.
- W4283825906 cites W3047768263 @default.
- W4283825906 cites W3084496392 @default.
- W4283825906 cites W3091354748 @default.
- W4283825906 cites W3091836206 @default.
- W4283825906 cites W3092964313 @default.
- W4283825906 cites W3125389502 @default.
- W4283825906 cites W3154462320 @default.
- W4283825906 cites W3158393837 @default.
- W4283825906 cites W3164645215 @default.
- W4283825906 cites W3206728444 @default.
- W4283825906 cites W3207844587 @default.
- W4283825906 cites W3213469059 @default.
- W4283825906 cites W4200462038 @default.
- W4283825906 cites W4200569725 @default.
- W4283825906 cites W4205241347 @default.
- W4283825906 cites W603604790 @default.
- W4283825906 doi "https://doi.org/10.3389/fnmol.2022.921908" @default.
- W4283825906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35875669" @default.