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• W4283826306 startingPage "2119" @default.
• W4283826306 abstract "Uterine cancers are among the most prevalent gynecological malignancies, and endometrial cancer (EC) is the most common in this group. This study used tissue-based proteomic profiling analysis in patients with endometrial cancer and hyperplasia, and control patients. Conventional 2D gel electrophoresis, followed by a mass spectrometry approach with bioinformatics, including a network pathway analysis pipeline, was used to identify differentially expressed proteins and associated metabolic pathways between the study groups. Thirty-six patients (twelve with endometrial cancer, twelve with hyperplasia, and twelve controls) were enrolled in this study. The mean age of the participants was 46-75 years. Eighty-seven proteins were significantly differentially expressed between the study groups, of which fifty-three were significantly differentially regulated (twenty-eight upregulated and twenty-five downregulated) in the tissue samples of EC patients compared to the control (Ctrl). Furthermore, 26 proteins were significantly dysregulated (8 upregulated and 18 downregulated) in tissue samples of hyperplasia (HY) patients compared to Ctrl. Thirty-two proteins (nineteen upregulated and thirteen downregulated) including desmin, peptidyl prolyl cis-trans isomerase A, and zinc finger protein 844 were downregulated in the EC group compared to the HY group. Additionally, fructose bisphosphate aldolase A, alpha enolase, and keratin type 1 cytoskeletal 10 were upregulated in the EC group compared to those in the HY group. The proteins identified in this study were known to regulate cellular processes (36%), followed by biological regulation (16%). Ingenuity pathway analysis found that proteins that are differentially expressed between EC and HY are linked to AKT, ACTA2, and other signaling pathways. The panels of protein markers identified in this study could be used as potential biomarkers for distinguishing between EC and HY and early diagnosis and progression of EC from hyperplasia and normal patients." @default.
• W4283826306 created "2022-07-07" @default.
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• W4283826306 date "2022-07-05" @default.
• W4283826306 modified "2023-10-16" @default.
• W4283826306 title "Tissue-Based Proteomic Profiling in Patients with Hyperplasia and Endometrial Cancer" @default.
• W4283826306 cites W1240518884 @default.
• W4283826306 cites W1568802323 @default.
• W4283826306 cites W1921408704 @default.
• W4283826306 cites W1938958967 @default.
• W4283826306 cites W1943183127 @default.
• W4283826306 cites W1983533553 @default.
• W4283826306 cites W1989970584 @default.
• W4283826306 cites W1991001514 @default.
• W4283826306 cites W2007497274 @default.
• W4283826306 cites W2017926450 @default.
• W4283826306 cites W2022156993 @default.
• W4283826306 cites W2022334439 @default.
• W4283826306 cites W2027709710 @default.
• W4283826306 cites W2036193515 @default.
• W4283826306 cites W2038851895 @default.
• W4283826306 cites W2042363992 @default.
• W4283826306 cites W2044869180 @default.
• W4283826306 cites W2052843371 @default.
• W4283826306 cites W2055695973 @default.
• W4283826306 cites W2060737324 @default.
• W4283826306 cites W2061842004 @default.
• W4283826306 cites W2070343411 @default.
• W4283826306 cites W2073485652 @default.
• W4283826306 cites W2086443735 @default.
• W4283826306 cites W2100792529 @default.
• W4283826306 cites W2113088032 @default.
• W4283826306 cites W2120818602 @default.
• W4283826306 cites W2131939253 @default.
• W4283826306 cites W2140132747 @default.
• W4283826306 cites W2141091417 @default.
• W4283826306 cites W2143249992 @default.
• W4283826306 cites W2149174039 @default.
• W4283826306 cites W2157079036 @default.
• W4283826306 cites W2157368620 @default.
• W4283826306 cites W2160307341 @default.
• W4283826306 cites W2161640106 @default.
• W4283826306 cites W2165577181 @default.
• W4283826306 cites W2165796043 @default.
• W4283826306 cites W2301311996 @default.
• W4283826306 cites W2334557060 @default.
• W4283826306 cites W2338065169 @default.
• W4283826306 cites W2494650813 @default.
• W4283826306 cites W2541579060 @default.
• W4283826306 cites W2548717227 @default.
• W4283826306 cites W2560518865 @default.
• W4283826306 cites W2566141610 @default.
• W4283826306 cites W2573688693 @default.
• W4283826306 cites W2603678320 @default.
• W4283826306 cites W2604744156 @default.
• W4283826306 cites W2612126101 @default.
• W4283826306 cites W2624119497 @default.
• W4283826306 cites W2768272363 @default.
• W4283826306 cites W2770899475 @default.
• W4283826306 cites W2773382622 @default.
• W4283826306 cites W2777052790 @default.
• W4283826306 cites W2782105874 @default.
• W4283826306 cites W2786036412 @default.
• W4283826306 cites W2801738826 @default.
• W4283826306 cites W2884209032 @default.
• W4283826306 cites W2885473049 @default.
• W4283826306 cites W2889646458 @default.
• W4283826306 cites W2891414824 @default.
• W4283826306 cites W2891969067 @default.
• W4283826306 cites W2901714724 @default.
• W4283826306 cites W2905538999 @default.
• W4283826306 cites W2906984453 @default.
• W4283826306 cites W2939938561 @default.
• W4283826306 cites W2948458637 @default.
• W4283826306 cites W2954552786 @default.
• W4283826306 cites W2966919529 @default.
• W4283826306 cites W2969720006 @default.
• W4283826306 cites W2976804353 @default.
• W4283826306 cites W2981009510 @default.
• W4283826306 cites W2981758397 @default.
• W4283826306 cites W2983258622 @default.
• W4283826306 cites W2989617581 @default.
• W4283826306 cites W2990300632 @default.
• W4283826306 cites W3003681551 @default.
• W4283826306 cites W3010335767 @default.
• W4283826306 cites W3012610662 @default.
• W4283826306 cites W3017786087 @default.
• W4283826306 cites W3033970423 @default.

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