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- W4283827639 abstract "Apoptosis is a form of programmed cell death that is essential for cellular and organismal homeostasis. Any irregularities that disturb the balance between apoptosis and cell survival have severe implications, such as improper development or life-threatening diseases. Thus, it is highly critical to maintain a proper rate of apoptosis throughout development. In fact, several complex transcriptional and posttranscriptional mechanisms exist in eukaryotes to critically regulate the rate of apoptotic processes. Recent studies suggest that not only RNA sequences but also their modifications, such as m6A methylation, play a fundamental role in these transcriptional and posttranscriptional processes. A specific set of proteins, called writer, eraser, and reader of m6A marks, modulate the rate of apoptosis by determining the m6A repertoire and the fate of certain transcripts associated with apoptosis. In this Review, we will cover the dynamic m6A RNA modifications and their impact on modulation of apoptosis." @default.
- W4283827639 created "2022-07-07" @default.
- W4283827639 creator A5004641946 @default.
- W4283827639 creator A5079338444 @default.
- W4283827639 date "2022-01-01" @default.
- W4283827639 modified "2023-09-26" @default.
- W4283827639 title "Epitranscriptomics Changes the Play: m6A RNA Modifications in Apoptosis" @default.
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- W4283827639 doi "https://doi.org/10.1007/5584_2022_721" @default.
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