Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283836483> ?p ?o ?g. }
- W4283836483 endingPage "2119" @default.
- W4283836483 startingPage "2098" @default.
- W4283836483 abstract "Abstract Current chimeric antigen receptor-modified (CAR) T-cell products are evaluated in bulk, without assessing functional heterogeneity. We therefore generated a comprehensive single-cell gene expression and T-cell receptor (TCR) sequencing data set using pre- and postinfusion CD19-CAR T cells from blood and bone marrow samples of pediatric patients with B-cell acute lymphoblastic leukemia. We identified cytotoxic postinfusion cells with identical TCRs to a subset of preinfusion CAR T cells. These effector precursor cells exhibited a unique transcriptional profile compared with other preinfusion cells, corresponding to an unexpected surface phenotype (TIGIT+, CD62Llo, CD27−). Upon stimulation, these cells showed functional superiority and decreased expression of the exhaustion-associated transcription factor TOX. Collectively, these results demonstrate diverse effector potentials within preinfusion CAR T-cell products, which can be exploited for therapeutic applications. Furthermore, we provide an integrative experimental and analytic framework for elucidating the mechanisms underlying effector development in CAR T-cell products. Significance: Utilizing clonal trajectories to define transcriptional potential, we find a unique signature of CAR T-cell effector precursors present in preinfusion cell products. Functional assessment of cells with this signature indicated early effector potential and resistance to exhaustion, consistent with postinfusion cellular patterns observed in patients. This article is highlighted in the In This Issue feature, p. 2007" @default.
- W4283836483 created "2022-07-07" @default.
- W4283836483 creator A5003176559 @default.
- W4283836483 creator A5005724506 @default.
- W4283836483 creator A5008792497 @default.
- W4283836483 creator A5009408760 @default.
- W4283836483 creator A5009930475 @default.
- W4283836483 creator A5013135532 @default.
- W4283836483 creator A5014859311 @default.
- W4283836483 creator A5015947780 @default.
- W4283836483 creator A5020737978 @default.
- W4283836483 creator A5024715014 @default.
- W4283836483 creator A5025724173 @default.
- W4283836483 creator A5028159948 @default.
- W4283836483 creator A5039514657 @default.
- W4283836483 creator A5040095629 @default.
- W4283836483 creator A5052284918 @default.
- W4283836483 creator A5056105964 @default.
- W4283836483 creator A5067758956 @default.
- W4283836483 creator A5074563161 @default.
- W4283836483 creator A5076790435 @default.
- W4283836483 creator A5077512801 @default.
- W4283836483 creator A5084315586 @default.
- W4283836483 creator A5086811460 @default.
- W4283836483 date "2022-07-06" @default.
- W4283836483 modified "2023-10-12" @default.
- W4283836483 title "Common Trajectories of Highly Effective CD19-Specific CAR T Cells Identified by Endogenous T-cell Receptor Lineages" @default.
- W4283836483 cites W1563668677 @default.
- W4283836483 cites W1910012553 @default.
- W4283836483 cites W1969192442 @default.
- W4283836483 cites W1973268693 @default.
- W4283836483 cites W1973639800 @default.
- W4283836483 cites W1987453246 @default.
- W4283836483 cites W1987897953 @default.
- W4283836483 cites W1994219871 @default.
- W4283836483 cites W2010607826 @default.
- W4283836483 cites W2018775174 @default.
- W4283836483 cites W2029399624 @default.
- W4283836483 cites W2050457398 @default.
- W4283836483 cites W2051241958 @default.
- W4283836483 cites W2052923881 @default.
- W4283836483 cites W2052977964 @default.
- W4283836483 cites W2067819949 @default.
- W4283836483 cites W2074101304 @default.
- W4283836483 cites W2089041106 @default.
- W4283836483 cites W2089601496 @default.
- W4283836483 cites W2099570622 @default.
- W4283836483 cites W2100626956 @default.
- W4283836483 cites W2118796952 @default.
- W4283836483 cites W2119319172 @default.
- W4283836483 cites W2119896120 @default.
- W4283836483 cites W2129702476 @default.
- W4283836483 cites W2144021776 @default.
- W4283836483 cites W2150892663 @default.
- W4283836483 cites W2173617309 @default.
- W4283836483 cites W2185265351 @default.
- W4283836483 cites W2570323108 @default.
- W4283836483 cites W2582033455 @default.
- W4283836483 cites W2589417329 @default.
- W4283836483 cites W2616922646 @default.
- W4283836483 cites W2761657464 @default.
- W4283836483 cites W2787621143 @default.
- W4283836483 cites W2794521141 @default.
- W4283836483 cites W2801641802 @default.
- W4283836483 cites W2907514116 @default.
- W4283836483 cites W2907549567 @default.
- W4283836483 cites W2921866483 @default.
- W4283836483 cites W2986728550 @default.
- W4283836483 cites W2992738455 @default.
- W4283836483 cites W2999928454 @default.
- W4283836483 cites W3006159345 @default.
- W4283836483 cites W3011164887 @default.
- W4283836483 cites W3036511929 @default.
- W4283836483 cites W3042460080 @default.
- W4283836483 cites W3044609915 @default.
- W4283836483 cites W3081294344 @default.
- W4283836483 cites W3092341078 @default.
- W4283836483 cites W3107369426 @default.
- W4283836483 cites W3131540301 @default.
- W4283836483 cites W3151543485 @default.
- W4283836483 cites W3164692211 @default.
- W4283836483 cites W3217544539 @default.
- W4283836483 cites W4224211066 @default.
- W4283836483 cites W4239510810 @default.
- W4283836483 cites W4280546371 @default.
- W4283836483 doi "https://doi.org/10.1158/2159-8290.cd-21-1508" @default.
- W4283836483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35792801" @default.
- W4283836483 hasPublicationYear "2022" @default.
- W4283836483 type Work @default.
- W4283836483 citedByCount "15" @default.
- W4283836483 countsByYear W42838364832021 @default.
- W4283836483 countsByYear W42838364832022 @default.
- W4283836483 countsByYear W42838364832023 @default.
- W4283836483 crossrefType "journal-article" @default.
- W4283836483 hasAuthorship W4283836483A5003176559 @default.
- W4283836483 hasAuthorship W4283836483A5005724506 @default.
- W4283836483 hasAuthorship W4283836483A5008792497 @default.
- W4283836483 hasAuthorship W4283836483A5009408760 @default.