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- W4284663453 endingPage "102601" @default.
- W4284663453 startingPage "102601" @default.
- W4284663453 abstract "Generalized anxiety disorder (GAD) and major depressive disorder (MDD) reliably precede and predict one another. However, there is insufficient data on mediators through which the longitudinal GAD-MDD association unfold. Based on insomnia theories, such as the hyperarousal model of sleep, we tested the degree to which poor global sleep quality functioned as a mediator of the prospective bidirectional anxiety-depression relationship. Participants were 3,294 community-dwelling adults who partook in three measurement waves nine years apart. The Composite International Diagnostic Interview-Short Form assessed GAD and MDD in-person at baseline (Time 1 [T1]), Time 2 (T2; nine years after T1), and 18 years later (T3). T2 global sleep quality was measured using the multiple-domain Pittsburgh Sleep Quality Index self-report at T2. We used longitudinal structural equation modeling mediation analyses. Analyses showed that higher T1 MDD and GAD severity individually predicted lower T2 global sleep quality (Cohen’s d = −0.561 to −0.480) and less T2 global sleep quality, thereby forecasted both higher T3 MDD and GAD (d = −0.275 to −0.190). Poorer T2 global sleep quality significantly mediated the T1 GAD–T3 MDD relation, explaining 41% of the association. Worse global sleep quality at T2 also significantly mediated the T1 MDD–T3 GAD association, mediating 11% of the T1 MDD–T3 GAD pathway. The results remained similar after controlling for multiple sociodemographic and clinical variables. Conclusions: Findings offer evidence for transdiagnostic theories of sleep and insomnia. Theoretical and clinical implications, such as prioritizing sleep improvement in cognitive-behavioral therapies, are also discussed." @default.
- W4284663453 created "2022-07-08" @default.
- W4284663453 creator A5015547139 @default.
- W4284663453 creator A5028772092 @default.
- W4284663453 creator A5056531935 @default.
- W4284663453 date "2022-08-01" @default.
- W4284663453 modified "2023-10-12" @default.
- W4284663453 title "Why Sleep is Key: Poor Sleep Quality is a Mechanism for the Bidirectional Relationship between Major Depressive Disorder and Generalized Anxiety Disorder Across 18 Years" @default.
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- W4284663453 doi "https://doi.org/10.1016/j.janxdis.2022.102601" @default.
- W4284663453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35850001" @default.
- W4284663453 hasPublicationYear "2022" @default.
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