FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284663765> ?p ?o ?g. }

• W4284663765 endingPage "1629" @default.
• W4284663765 startingPage "1616" @default.
• W4284663765 abstract "Abstract Background Alcohol withdrawal is a key component of severe alcohol use disorder. Animal models of alcohol withdrawal tend to focus on traditional anxiety/stress tests. While these have been essential to advancing our understanding of the biology of alcohol withdrawal, abrupt cessation of drinking following heavy alcohol consumption can also trigger withdrawal‐related affective states that impact responses to a variety of life events and stressors. To this end, we show that behaviors in a variety of tasks that differ in task demand and intensity are altered during withdrawal in male and female mice after voluntary alcohol access. Methods Male and female miceunderwent six weeks of intermittent two‐bottle choice alcohol exposure followed by behavioral tests. The tests included—Home cage: low‐stress baseline environment to measure spontaneous natural behaviors; Open field: anxiety‐inducing bright novel environment; Looming disc: arena with a protective hut where mice are exposed to a series of discs that mimic an overhead advancing predator, and Robogator‐simulated predator task: forced foraging behavioral choice in the presence of an advancing robot predator that “attacks” when mice are near a food pellet in a large open arena. Results A history of alcohol exposure impacted behaviors in these tasks in a sex‐dependent manner. In the home cage, alcohol induced reductions in digging and heightened stress coping through an increase in grooming time. In males, increased rearing yielded greater vigilance/exploration in a familiar environment. The open‐field test revealed an anxiety phenotype in both male and female mice exposed to alcohol. Male mice showed no behavioral alterations to the looming disc task, while females exposed to alcohol showed greater escape responses than water controls, indicative of active stress‐response behaviors. In males, the Robogator task revealed a hesitant/avoidant phenotype in alcohol‐exposed mice under greater task demands. Conclusions Few drugs show robust evidence of efficacy in clinical trials for alcohol withdrawal. Understanding how withdrawal alters a variety of behaviors in both males and females that are linked to stress coping can increase our understanding of alcohol misuse and aid in developing better medications for treating individuals with AUD." @default.
• W4284663765 created "2022-07-08" @default.
• W4284663765 creator A5009239531 @default.
• W4284663765 creator A5010192376 @default.
• W4284663765 creator A5012127614 @default.
• W4284663765 creator A5055523904 @default.
• W4284663765 creator A5064645727 @default.
• W4284663765 creator A5072148139 @default.
• W4284663765 creator A5074843443 @default.
• W4284663765 creator A5076705421 @default.
• W4284663765 creator A5086564561 @default.
• W4284663765 creator A5089118800 @default.
• W4284663765 date "2022-07-18" @default.
• W4284663765 modified "2023-10-16" @default.
• W4284663765 title "Chronic alcohol consumption alters home‐cage behaviors and responses to ethologically relevant predator tasks in mice" @default.
• W4284663765 cites W112510839 @default.
• W4284663765 cites W1475399421 @default.
• W4284663765 cites W1587734848 @default.
• W4284663765 cites W1731924710 @default.
• W4284663765 cites W1829470622 @default.
• W4284663765 cites W1839224009 @default.
• W4284663765 cites W1979024772 @default.
• W4284663765 cites W1982596294 @default.
• W4284663765 cites W1992413015 @default.
• W4284663765 cites W1993063573 @default.
• W4284663765 cites W1994122020 @default.
• W4284663765 cites W2000031660 @default.
• W4284663765 cites W2001895216 @default.
• W4284663765 cites W2002387320 @default.
• W4284663765 cites W2002937105 @default.
• W4284663765 cites W2003584239 @default.
• W4284663765 cites W2011981060 @default.
• W4284663765 cites W2013727765 @default.
• W4284663765 cites W2018065178 @default.
• W4284663765 cites W2019062333 @default.
• W4284663765 cites W2027116047 @default.
• W4284663765 cites W2034205729 @default.
• W4284663765 cites W2044518316 @default.
• W4284663765 cites W2047197211 @default.
• W4284663765 cites W2062333750 @default.
• W4284663765 cites W2068607427 @default.
• W4284663765 cites W2078340953 @default.
• W4284663765 cites W2079153787 @default.
• W4284663765 cites W2079707826 @default.
• W4284663765 cites W2105130852 @default.
• W4284663765 cites W2121753308 @default.
• W4284663765 cites W2149050611 @default.
• W4284663765 cites W2162992969 @default.
• W4284663765 cites W2166603321 @default.
• W4284663765 cites W2171440972 @default.
• W4284663765 cites W2286968510 @default.
• W4284663765 cites W2326102634 @default.
• W4284663765 cites W2436596660 @default.
• W4284663765 cites W2461644430 @default.
• W4284663765 cites W2490725529 @default.
• W4284663765 cites W2502955213 @default.
• W4284663765 cites W2513315503 @default.
• W4284663765 cites W2528191300 @default.
• W4284663765 cites W2537002631 @default.
• W4284663765 cites W2583762848 @default.
• W4284663765 cites W2607341885 @default.
• W4284663765 cites W2612050222 @default.
• W4284663765 cites W2620167096 @default.
• W4284663765 cites W2738977230 @default.
• W4284663765 cites W2760374483 @default.
• W4284663765 cites W2772969143 @default.
• W4284663765 cites W2782219406 @default.
• W4284663765 cites W2793877036 @default.
• W4284663765 cites W2794918217 @default.
• W4284663765 cites W2809112603 @default.
• W4284663765 cites W2869819246 @default.
• W4284663765 cites W2887114371 @default.
• W4284663765 cites W2887443148 @default.
• W4284663765 cites W2891460750 @default.
• W4284663765 cites W2914644197 @default.
• W4284663765 cites W2922420559 @default.
• W4284663765 cites W2980242459 @default.
• W4284663765 cites W2984369896 @default.
• W4284663765 cites W3005833620 @default.
• W4284663765 cites W3005982472 @default.
• W4284663765 cites W3016904080 @default.
• W4284663765 cites W3019538919 @default.
• W4284663765 cites W3047712266 @default.
• W4284663765 cites W3129884138 @default.
• W4284663765 cites W4206379767 @default.
• W4284663765 cites W4213309180 @default.
• W4284663765 doi "https://doi.org/10.1111/acer.14901" @default.
• W4284663765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35797227" @default.
• W4284663765 hasPublicationYear "2022" @default.
• W4284663765 type Work @default.
• W4284663765 citedByCount "7" @default.
• W4284663765 countsByYear W42846637652022 @default.
• W4284663765 countsByYear W42846637652023 @default.
• W4284663765 crossrefType "journal-article" @default.
• W4284663765 hasAuthorship W4284663765A5009239531 @default.
• W4284663765 hasAuthorship W4284663765A5010192376 @default.
• W4284663765 hasAuthorship W4284663765A5012127614 @default.
• W4284663765 hasAuthorship W4284663765A5055523904 @default.

• next