FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284665919> ?p ?o ?g. }

• W4284665919 endingPage "558" @default.
• W4284665919 startingPage "549" @default.
• W4284665919 abstract "Recently, research has been conducted with chimeric antigen receptor (CAR)-T cells to improve efficacy against solid tumors. Humanized CAR improved the long-term survival of CAR-T cells in patients' peripheral blood, resulting in increased therapeutic efficacy. Therefore, the humanization of the CAR-gene sequence is considered an effective method. Podoplanin (PDPN) is a glycosylated transmembrane protein that is highly expressed in solid tumors and is associated with poor prognosis in patients with cancer. Therefore, PDPN is considered a biomarker and good target for cancer treatment with CAR-T cells. Previously, an anti-PDPN CAR was generated from a conventional nonhumanized antibody-NZ-1, the only anti-PDPN antibody for which a CAR was produced. In this study, we investigated other anti-PDPN CARs from the antibody NZ-27, or humanized NZ-1, to enhance the therapeutic potential of CAR-T cells. The CAR signal intensity was enhanced by the efficient expression of CAR proteins on the T-cell surface of NZ-27 CAR-T cells, which show tumor-specific cytotoxicity, proinflammatory cytokine production, and anti-tumor activity against PDPN-expressing tumor xenografts in mice that were significantly better than those in nonhumanized NZ-1 CAR-T cells." @default.
• W4284665919 created "2022-07-08" @default.
• W4284665919 creator A5032655219 @default.
• W4284665919 creator A5037659404 @default.
• W4284665919 creator A5053775529 @default.
• W4284665919 creator A5060363731 @default.
• W4284665919 creator A5073259968 @default.
• W4284665919 creator A5074657655 @default.
• W4284665919 date "2022-07-17" @default.
• W4284665919 modified "2023-10-15" @default.
• W4284665919 title "Improved anti‐solid tumor response by humanized anti‐podoplanin chimeric antigen receptor transduced human cytotoxic T cells in an animal model" @default.
• W4284665919 cites W1970842110 @default.
• W4284665919 cites W1988429312 @default.
• W4284665919 cites W1993058286 @default.
• W4284665919 cites W1994993231 @default.
• W4284665919 cites W2006796442 @default.
• W4284665919 cites W2016941384 @default.
• W4284665919 cites W2018042261 @default.
• W4284665919 cites W2024318945 @default.
• W4284665919 cites W2025787130 @default.
• W4284665919 cites W2100387226 @default.
• W4284665919 cites W2120391794 @default.
• W4284665919 cites W2128183896 @default.
• W4284665919 cites W2144967802 @default.
• W4284665919 cites W2148583422 @default.
• W4284665919 cites W2151853926 @default.
• W4284665919 cites W2268290622 @default.
• W4284665919 cites W2398243892 @default.
• W4284665919 cites W2592882744 @default.
• W4284665919 cites W2613539552 @default.
• W4284665919 cites W2755866416 @default.
• W4284665919 cites W2792588868 @default.
• W4284665919 cites W3013770476 @default.
• W4284665919 cites W3046025665 @default.
• W4284665919 cites W3080368074 @default.
• W4284665919 cites W3093736393 @default.
• W4284665919 cites W3122702917 @default.
• W4284665919 cites W3128689211 @default.
• W4284665919 cites W3173305141 @default.
• W4284665919 cites W4205217321 @default.
• W4284665919 doi "https://doi.org/10.1111/gtc.12972" @default.
• W4284665919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35790497" @default.
• W4284665919 hasPublicationYear "2022" @default.
• W4284665919 type Work @default.
• W4284665919 citedByCount "8" @default.
• W4284665919 countsByYear W42846659192023 @default.
• W4284665919 crossrefType "journal-article" @default.
• W4284665919 hasAuthorship W4284665919A5032655219 @default.
• W4284665919 hasAuthorship W4284665919A5037659404 @default.
• W4284665919 hasAuthorship W4284665919A5053775529 @default.
• W4284665919 hasAuthorship W4284665919A5060363731 @default.
• W4284665919 hasAuthorship W4284665919A5073259968 @default.
• W4284665919 hasAuthorship W4284665919A5074657655 @default.
• W4284665919 hasBestOaLocation W42846659191 @default.
• W4284665919 hasConcept C109316439 @default.
• W4284665919 hasConcept C147483822 @default.
• W4284665919 hasConcept C154317977 @default.
• W4284665919 hasConcept C159654299 @default.
• W4284665919 hasConcept C181152851 @default.
• W4284665919 hasConcept C202751555 @default.
• W4284665919 hasConcept C203014093 @default.
• W4284665919 hasConcept C2777701055 @default.
• W4284665919 hasConcept C2909316934 @default.
• W4284665919 hasConcept C3875195 @default.
• W4284665919 hasConcept C502942594 @default.
• W4284665919 hasConcept C55493867 @default.
• W4284665919 hasConcept C86803240 @default.
• W4284665919 hasConcept C8891405 @default.
• W4284665919 hasConceptScore W4284665919C109316439 @default.
• W4284665919 hasConceptScore W4284665919C147483822 @default.
• W4284665919 hasConceptScore W4284665919C154317977 @default.
• W4284665919 hasConceptScore W4284665919C159654299 @default.
• W4284665919 hasConceptScore W4284665919C181152851 @default.
• W4284665919 hasConceptScore W4284665919C202751555 @default.
• W4284665919 hasConceptScore W4284665919C203014093 @default.
• W4284665919 hasConceptScore W4284665919C2777701055 @default.
• W4284665919 hasConceptScore W4284665919C2909316934 @default.
• W4284665919 hasConceptScore W4284665919C3875195 @default.
• W4284665919 hasConceptScore W4284665919C502942594 @default.
• W4284665919 hasConceptScore W4284665919C55493867 @default.
• W4284665919 hasConceptScore W4284665919C86803240 @default.
• W4284665919 hasConceptScore W4284665919C8891405 @default.
• W4284665919 hasFunder F4320311405 @default.
• W4284665919 hasIssue "9" @default.
• W4284665919 hasLocation W42846659191 @default.
• W4284665919 hasLocation W42846659192 @default.
• W4284665919 hasLocation W42846659193 @default.
• W4284665919 hasOpenAccess W4284665919 @default.
• W4284665919 hasPrimaryLocation W42846659191 @default.
• W4284665919 hasRelatedWork W1484759019 @default.
• W4284665919 hasRelatedWork W1974496092 @default.
• W4284665919 hasRelatedWork W1996150995 @default.
• W4284665919 hasRelatedWork W2040191638 @default.
• W4284665919 hasRelatedWork W2041811834 @default.
• W4284665919 hasRelatedWork W2220102944 @default.
• W4284665919 hasRelatedWork W2409441623 @default.
• W4284665919 hasRelatedWork W3180719608 @default.
• W4284665919 hasRelatedWork W339756260 @default.

• next