Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284667809> ?p ?o ?g. }
- W4284667809 abstract "ABSTRACT Long noncoding RNAs (lncRNAs) are emerging as critical regulators of heart physiology and disease, although the studies unveiling their modes-of-action are still limited to few examples. We recently identified pCharme, a chromatin-associated lncRNA whose functional knockout in mice results in defective myogenesis and morphological remodelling of the cardiac muscle. Here, we combined Cap-Analysis of Gene Expression (CAGE), single-cell (sc)RNA sequencing and whole-mount in situ hybridization analyses to study pCharme cardiac expression. Since the early steps of cardiomyogenesis, we found the lncRNA being specifically restricted to cardiomyocytes, where it assists the formation of specific nuclear condensates containing MATR3, as well as important RNAs for cardiac development. In line with the functional significance of these activities, pCharme ablation in mice results in a delayed maturation of cardiomyocytes, which ultimately leads to morphological alterations of the myocardium and ventricular hypo-trabeculation. Since congenital anomalies in myocardium are clinically relevant in humans and predispose patients to major complications, the identification of novel genes controlling cardiac morphology becomes crucial. Our study offers unique insights into a novel lncRNA-mediated regulatory mechanism promoting cardiomyocyte maturation and bears relevance to Charme locus for future theranostic applications." @default.
- W4284667809 created "2022-07-08" @default.
- W4284667809 creator A5015570184 @default.
- W4284667809 creator A5017258937 @default.
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- W4284667809 creator A5031467506 @default.
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- W4284667809 creator A5087160015 @default.
- W4284667809 date "2022-07-05" @default.
- W4284667809 modified "2023-10-18" @default.
- W4284667809 title "The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart" @default.
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