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- W4284668059 endingPage "1323" @default.
- W4284668059 startingPage "1323" @default.
- W4284668059 abstract "The gastrointestinal tract is a unique organ containing both vascular and luminal routes lined by epithelial cells forming the mucosa, which play an important role in the entry of nutrients and act as a selective barrier, excluding potentially harmful agents. Mucosal surfaces establish a selective barrier between hostile external environments and the internal milieu. Heme is a major nutritional source of iron and is a pro-oxidant that causes oxidative stress. Heme oxygenases (HOs) catalyze the rate-limiting step in heme degradation, resulting in the formation of iron, carbon monoxide, and biliverdin, which are subsequently converted to bilirubin by biliverdin reductase. In gastrointestinal pathogenesis, HO-1, an inducible isoform of HO, is markedly induced in epithelial cells and plays an important role in protecting mucosal cells. Recent studies have focused on the biological effects of the products of this enzymatic reaction, which have antioxidant, anti-inflammatory, and cytoprotective functions. In this review, the essential roles of HO in the gastrointestinal tract are summarized, focusing on nutrient absorption, protection against cellular stresses, and the maintenance and regulation of tight junction proteins, emphasizing the potential therapeutic implications. The biochemical basis of the potential therapeutic implications of glutamine for HO-1 induction in gastrointestinal injury is also discussed." @default.
- W4284668059 created "2022-07-08" @default.
- W4284668059 creator A5048719914 @default.
- W4284668059 date "2022-07-05" @default.
- W4284668059 modified "2023-10-05" @default.
- W4284668059 title "Role of Heme Oxygenase in Gastrointestinal Epithelial Cells" @default.
- W4284668059 cites W124251429 @default.
- W4284668059 cites W1521068719 @default.
- W4284668059 cites W1529417609 @default.
- W4284668059 cites W1586487499 @default.
- W4284668059 cites W1588064010 @default.
- W4284668059 cites W1591048367 @default.
- W4284668059 cites W1592939002 @default.
- W4284668059 cites W1599595176 @default.
- W4284668059 cites W1600690434 @default.
- W4284668059 cites W1612925887 @default.
- W4284668059 cites W1860872598 @default.
- W4284668059 cites W1861720226 @default.
- W4284668059 cites W1901447316 @default.
- W4284668059 cites W1963718173 @default.
- W4284668059 cites W1965084345 @default.
- W4284668059 cites W1966582616 @default.
- W4284668059 cites W1970652880 @default.
- W4284668059 cites W1970725926 @default.
- W4284668059 cites W1973404578 @default.
- W4284668059 cites W1973646725 @default.
- W4284668059 cites W1974361621 @default.
- W4284668059 cites W1975676115 @default.
- W4284668059 cites W1977094630 @default.
- W4284668059 cites W1979338609 @default.
- W4284668059 cites W1979350212 @default.
- W4284668059 cites W1981561071 @default.
- W4284668059 cites W1981724053 @default.
- W4284668059 cites W1982361389 @default.
- W4284668059 cites W1984352151 @default.
- W4284668059 cites W1986333802 @default.
- W4284668059 cites W1986525923 @default.
- W4284668059 cites W1987083790 @default.
- W4284668059 cites W1987253641 @default.
- W4284668059 cites W1990756467 @default.
- W4284668059 cites W1991202028 @default.
- W4284668059 cites W1992277748 @default.
- W4284668059 cites W1992496431 @default.
- W4284668059 cites W1994141379 @default.
- W4284668059 cites W1996779616 @default.
- W4284668059 cites W1996846571 @default.
- W4284668059 cites W1997183854 @default.
- W4284668059 cites W1998416383 @default.
- W4284668059 cites W1999788344 @default.
- W4284668059 cites W2001019228 @default.
- W4284668059 cites W2001931295 @default.
- W4284668059 cites W2002072388 @default.
- W4284668059 cites W2002652481 @default.
- W4284668059 cites W2004307230 @default.
- W4284668059 cites W2005904261 @default.
- W4284668059 cites W2007771620 @default.
- W4284668059 cites W2015640955 @default.
- W4284668059 cites W2016603646 @default.
- W4284668059 cites W2017072280 @default.
- W4284668059 cites W2017851289 @default.
- W4284668059 cites W2018306049 @default.
- W4284668059 cites W2019945571 @default.
- W4284668059 cites W2028224423 @default.
- W4284668059 cites W2031222362 @default.
- W4284668059 cites W2036163599 @default.
- W4284668059 cites W2036368651 @default.
- W4284668059 cites W2038172495 @default.
- W4284668059 cites W2040914752 @default.
- W4284668059 cites W2041299296 @default.
- W4284668059 cites W2041553103 @default.
- W4284668059 cites W2041637256 @default.
- W4284668059 cites W2044730191 @default.
- W4284668059 cites W2045320558 @default.
- W4284668059 cites W2045938346 @default.
- W4284668059 cites W2046582521 @default.
- W4284668059 cites W2048527381 @default.
- W4284668059 cites W2049800847 @default.
- W4284668059 cites W2051793369 @default.
- W4284668059 cites W2052896018 @default.
- W4284668059 cites W2054302099 @default.
- W4284668059 cites W2054998714 @default.
- W4284668059 cites W2055378014 @default.
- W4284668059 cites W2055681603 @default.
- W4284668059 cites W2056183344 @default.
- W4284668059 cites W2059325107 @default.
- W4284668059 cites W2059441862 @default.
- W4284668059 cites W2060139051 @default.
- W4284668059 cites W2062145087 @default.
- W4284668059 cites W2065982972 @default.
- W4284668059 cites W2066684838 @default.
- W4284668059 cites W2068337911 @default.
- W4284668059 cites W2069077826 @default.
- W4284668059 cites W2071307185 @default.
- W4284668059 cites W2077300226 @default.
- W4284668059 cites W2077358733 @default.
- W4284668059 cites W2086410486 @default.
- W4284668059 cites W2089772634 @default.
- W4284668059 cites W2090060053 @default.