Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284668081> ?p ?o ?g. }
- W4284668081 endingPage "e1010681" @default.
- W4284668081 startingPage "e1010681" @default.
- W4284668081 abstract "During hematogenously disseminated candidiasis, blood borne fungi must invade the endothelial cells that line the blood vessels to infect the deep tissues. Although Candida albicans, which forms hyphae, readily invades endothelial cells, other medically important species of Candida are poorly invasive in standard in vitro assays and have low virulence in immunocompetent mouse models of disseminated infection. Here, we show that Candida glabrata, Candida tropicalis, Candida parapsilosis, and Candida krusei can bind to vitronectin and high molecular weight kininogen present in human serum. Acting as bridging molecules, vitronectin and kininogen bind to αv integrins and the globular C1q receptor (gC1qR), inducing human endothelial cells to endocytose the fungus. This mechanism of endothelial cell invasion is poorly supported by mouse endothelial cells but can be restored when mouse endothelial cells are engineered to express human gC1qR or αv integrin. Overall, these data indicate that bridging molecule-mediated endocytosis is a common pathogenic strategy used by many medically important Candida spp. to invade human vascular endothelial cells." @default.
- W4284668081 created "2022-07-08" @default.
- W4284668081 creator A5010567627 @default.
- W4284668081 creator A5012804086 @default.
- W4284668081 creator A5013000959 @default.
- W4284668081 creator A5017382091 @default.
- W4284668081 creator A5023246115 @default.
- W4284668081 creator A5032603923 @default.
- W4284668081 creator A5057287134 @default.
- W4284668081 creator A5064391516 @default.
- W4284668081 creator A5066754592 @default.
- W4284668081 creator A5090798603 @default.
- W4284668081 date "2022-07-07" @default.
- W4284668081 modified "2023-10-17" @default.
- W4284668081 title "Serum bridging molecules drive candidal invasion of human but not mouse endothelial cells" @default.
- W4284668081 cites W1485548301 @default.
- W4284668081 cites W1500387969 @default.
- W4284668081 cites W1938044578 @default.
- W4284668081 cites W1960657042 @default.
- W4284668081 cites W1967493968 @default.
- W4284668081 cites W1974177779 @default.
- W4284668081 cites W1984156594 @default.
- W4284668081 cites W1987762500 @default.
- W4284668081 cites W1992685096 @default.
- W4284668081 cites W1999340863 @default.
- W4284668081 cites W2002321751 @default.
- W4284668081 cites W2005698531 @default.
- W4284668081 cites W2006951698 @default.
- W4284668081 cites W2012047636 @default.
- W4284668081 cites W2019191000 @default.
- W4284668081 cites W2029253573 @default.
- W4284668081 cites W2031836717 @default.
- W4284668081 cites W2037007916 @default.
- W4284668081 cites W2043480939 @default.
- W4284668081 cites W2044629043 @default.
- W4284668081 cites W2057760963 @default.
- W4284668081 cites W2058268415 @default.
- W4284668081 cites W2058303670 @default.
- W4284668081 cites W2063145009 @default.
- W4284668081 cites W2064487923 @default.
- W4284668081 cites W2070265193 @default.
- W4284668081 cites W2074459763 @default.
- W4284668081 cites W2077596769 @default.
- W4284668081 cites W2078726734 @default.
- W4284668081 cites W2086514052 @default.
- W4284668081 cites W2090227081 @default.
- W4284668081 cites W2101796369 @default.
- W4284668081 cites W2112367826 @default.
- W4284668081 cites W2114192906 @default.
- W4284668081 cites W2116308765 @default.
- W4284668081 cites W2121224809 @default.
- W4284668081 cites W2127891436 @default.
- W4284668081 cites W2133054734 @default.
- W4284668081 cites W2133183053 @default.
- W4284668081 cites W2133711395 @default.
- W4284668081 cites W2134152581 @default.
- W4284668081 cites W2157512355 @default.
- W4284668081 cites W2157603347 @default.
- W4284668081 cites W2157833701 @default.
- W4284668081 cites W2158314241 @default.
- W4284668081 cites W2169759160 @default.
- W4284668081 cites W2291810640 @default.
- W4284668081 cites W2313337168 @default.
- W4284668081 cites W2329943654 @default.
- W4284668081 cites W2810905331 @default.
- W4284668081 cites W2899489704 @default.
- W4284668081 cites W2965402820 @default.
- W4284668081 cites W4225752354 @default.
- W4284668081 doi "https://doi.org/10.1371/journal.ppat.1010681" @default.
- W4284668081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35797411" @default.
- W4284668081 hasPublicationYear "2022" @default.
- W4284668081 type Work @default.
- W4284668081 citedByCount "2" @default.
- W4284668081 countsByYear W42846680812023 @default.
- W4284668081 crossrefType "journal-article" @default.
- W4284668081 hasAuthorship W4284668081A5010567627 @default.
- W4284668081 hasAuthorship W4284668081A5012804086 @default.
- W4284668081 hasAuthorship W4284668081A5013000959 @default.
- W4284668081 hasAuthorship W4284668081A5017382091 @default.
- W4284668081 hasAuthorship W4284668081A5023246115 @default.
- W4284668081 hasAuthorship W4284668081A5032603923 @default.
- W4284668081 hasAuthorship W4284668081A5057287134 @default.
- W4284668081 hasAuthorship W4284668081A5064391516 @default.
- W4284668081 hasAuthorship W4284668081A5066754592 @default.
- W4284668081 hasAuthorship W4284668081A5090798603 @default.
- W4284668081 hasBestOaLocation W42846680811 @default.
- W4284668081 hasConcept C123012128 @default.
- W4284668081 hasConcept C164144092 @default.
- W4284668081 hasConcept C170493617 @default.
- W4284668081 hasConcept C195687474 @default.
- W4284668081 hasConcept C202751555 @default.
- W4284668081 hasConcept C2780670043 @default.
- W4284668081 hasConcept C2780917455 @default.
- W4284668081 hasConcept C28005876 @default.
- W4284668081 hasConcept C55493867 @default.
- W4284668081 hasConcept C86803240 @default.
- W4284668081 hasConcept C89423630 @default.
- W4284668081 hasConcept C95444343 @default.