FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284675779> ?p ?o ?g. }

• W4284675779 abstract "Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematologic malignancies. Alloreactivity after HSCT is known to be mediated by adaptive immune cells expressing rearranging receptors. Recent studies demonstrated that the innate immune system could likewise sense the non-self signals and subsequently enhance the alloimmune response. We recently demonstrated that the donor/recipient mismatch of signal regulatory protein α (SIRPα), an immunoglobulin receptor exclusively expressed on innate cells, is associated with a higher risk of cGVHD and relapse protection in a cohort of acute myeloid leukemia patients who underwent allo-HSCT. Whether these effects also occur in other hematologic malignancies remains unclear. In the present study, we compared outcomes by SIRPα match status in a cohort of 310 patients who received allo-HSCT from an HLA matched-related donor for the treatment of lymphoid malignancies. Multivariable analysis showed that SIRPα mismatch was associated with a significantly higher rate of cGVHD (hazard ratio [HR] 1.8, P= .002), cGVHD requiring systemic immunosuppressive therapy (HR 1.9, P= .005), a lower rate of disease progression (HR 0.5, P= .003) and improved progression-free survival (HR 0.5, P= .001). Notably, the effects of SIRPα mismatch were observed only in the patients who achieved >95% of donor T-cell chimerism. The mismatch in SIRPα is associated with favorable relapse protection and concurrently increased risk of cGVHD in patients who undergo allo-HSCT for lymphoid malignancies, and the optimal donor could be selected based on the finding of the study to mitigate the risk of GVHD and relapse." @default.
• W4284675779 created "2022-07-08" @default.
• W4284675779 creator A5002039083 @default.
• W4284675779 creator A5005488530 @default.
• W4284675779 creator A5007244861 @default.
• W4284675779 creator A5008975834 @default.
• W4284675779 creator A5016928938 @default.
• W4284675779 creator A5026568196 @default.
• W4284675779 creator A5028405515 @default.
• W4284675779 creator A5034104852 @default.
• W4284675779 creator A5038619722 @default.
• W4284675779 creator A5038851564 @default.
• W4284675779 creator A5047522685 @default.
• W4284675779 creator A5048913229 @default.
• W4284675779 creator A5055885795 @default.
• W4284675779 creator A5056663125 @default.
• W4284675779 creator A5062286758 @default.
• W4284675779 creator A5063600595 @default.
• W4284675779 creator A5075342012 @default.
• W4284675779 creator A5091083304 @default.
• W4284675779 date "2022-07-07" @default.
• W4284675779 modified "2023-10-18" @default.
• W4284675779 title "SIRPα Mismatch Is Associated With Relapse Protection and Chronic Graft-Versus-Host Disease After Related Hematopoietic Stem Cell Transplantation for Lymphoid Malignancies" @default.
• W4284675779 cites W1798881623 @default.
• W4284675779 cites W1981878585 @default.
• W4284675779 cites W2003407014 @default.
• W4284675779 cites W2028887498 @default.
• W4284675779 cites W2045254759 @default.
• W4284675779 cites W2086149900 @default.
• W4284675779 cites W2090340378 @default.
• W4284675779 cites W2098877898 @default.
• W4284675779 cites W2114072750 @default.
• W4284675779 cites W2141253335 @default.
• W4284675779 cites W2528127065 @default.
• W4284675779 cites W2529648056 @default.
• W4284675779 cites W2607613192 @default.
• W4284675779 cites W2717813247 @default.
• W4284675779 cites W2736476343 @default.
• W4284675779 cites W2770192040 @default.
• W4284675779 cites W2795318100 @default.
• W4284675779 cites W2911813338 @default.
• W4284675779 cites W2915736956 @default.
• W4284675779 cites W2950984691 @default.
• W4284675779 cites W2952598829 @default.
• W4284675779 cites W3019532772 @default.
• W4284675779 cites W3026660164 @default.
• W4284675779 cites W3028978765 @default.
• W4284675779 cites W3031429653 @default.
• W4284675779 cites W3118995603 @default.
• W4284675779 cites W3194206923 @default.
• W4284675779 cites W3196944986 @default.
• W4284675779 doi "https://doi.org/10.3389/fimmu.2022.904718" @default.
• W4284675779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35874659" @default.
• W4284675779 hasPublicationYear "2022" @default.
• W4284675779 type Work @default.
• W4284675779 citedByCount "0" @default.
• W4284675779 crossrefType "journal-article" @default.
• W4284675779 hasAuthorship W4284675779A5002039083 @default.
• W4284675779 hasAuthorship W4284675779A5005488530 @default.
• W4284675779 hasAuthorship W4284675779A5007244861 @default.
• W4284675779 hasAuthorship W4284675779A5008975834 @default.
• W4284675779 hasAuthorship W4284675779A5016928938 @default.
• W4284675779 hasAuthorship W4284675779A5026568196 @default.
• W4284675779 hasAuthorship W4284675779A5028405515 @default.
• W4284675779 hasAuthorship W4284675779A5034104852 @default.
• W4284675779 hasAuthorship W4284675779A5038619722 @default.
• W4284675779 hasAuthorship W4284675779A5038851564 @default.
• W4284675779 hasAuthorship W4284675779A5047522685 @default.
• W4284675779 hasAuthorship W4284675779A5048913229 @default.
• W4284675779 hasAuthorship W4284675779A5055885795 @default.
• W4284675779 hasAuthorship W4284675779A5056663125 @default.
• W4284675779 hasAuthorship W4284675779A5062286758 @default.
• W4284675779 hasAuthorship W4284675779A5063600595 @default.
• W4284675779 hasAuthorship W4284675779A5075342012 @default.
• W4284675779 hasAuthorship W4284675779A5091083304 @default.
• W4284675779 hasBestOaLocation W42846757791 @default.
• W4284675779 hasConcept C126322002 @default.
• W4284675779 hasConcept C143998085 @default.
• W4284675779 hasConcept C203014093 @default.
• W4284675779 hasConcept C207103383 @default.
• W4284675779 hasConcept C2777408962 @default.
• W4284675779 hasConcept C2779282312 @default.
• W4284675779 hasConcept C2779972918 @default.
• W4284675779 hasConcept C2911091166 @default.
• W4284675779 hasConcept C44249647 @default.
• W4284675779 hasConcept C71924100 @default.
• W4284675779 hasConcept C72563966 @default.
• W4284675779 hasConcept C8891405 @default.
• W4284675779 hasConceptScore W4284675779C126322002 @default.
• W4284675779 hasConceptScore W4284675779C143998085 @default.
• W4284675779 hasConceptScore W4284675779C203014093 @default.
• W4284675779 hasConceptScore W4284675779C207103383 @default.
• W4284675779 hasConceptScore W4284675779C2777408962 @default.
• W4284675779 hasConceptScore W4284675779C2779282312 @default.
• W4284675779 hasConceptScore W4284675779C2779972918 @default.
• W4284675779 hasConceptScore W4284675779C2911091166 @default.
• W4284675779 hasConceptScore W4284675779C44249647 @default.
• W4284675779 hasConceptScore W4284675779C71924100 @default.
• W4284675779 hasConceptScore W4284675779C72563966 @default.
• W4284675779 hasConceptScore W4284675779C8891405 @default.

• next