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• W4284682009 abstract "Abstract Chronic wounds impose a significant healthcare burden to a broad patient population. Cell based therapies, while having shown benefits for the treatment of chronic wounds, have not achieved widespread adoption into clinical practice. Here, we developed a novel CRISPR/Cas9 approach to precisely edit dendritic cells (DCs) to enhance their therapeutic potential for healing chronic wounds. Using single-cell RNA sequencing (scRNA-seq) of tolerogenic DCs, we discover N-myc downregulated gene 2 ( Ndrg2 ), which marks a specific population of DC progenitors, as a promising target for CRISPR knockout (KO). Ndrg2 -KO alters the transcriptomic profile of DCs and preserves an immature cell state with a strong, pro-angiogenic and regenerative capacity. We then incorporated our CRISPR-based cell engineering within a hydrogel technology for in vivo cell delivery and developed a highly effective translational approach for DC based immunotherapy that accelerated healing of full-thickness wounds in both non-diabetic and diabetic mouse models. These findings could open the door to future clinical trials using safe gene editing in DCs for treating various types of chronic wounds." @default.
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• W4284682009 date "2022-07-05" @default.
• W4284682009 modified "2023-10-02" @default.
• W4284682009 title "Cas9-Mediated Knockout of Ndrg2 Enhances the Regenerative Potential of Dendritic Cells for Wound Healing" @default.
• W4284682009 doi "https://doi.org/10.21203/rs.3.rs-1781479/v1" @default.
• W4284682009 hasPublicationYear "2022" @default.
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