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- W4284683238 abstract "The use of many essential drugs is restricted due to their deleterious effects on the liver. Molecules that can prevent or protect the liver from drug-induced liver injury (DILI) would be invaluable in such situations. We used a transgenic line in zebrafish with a hepatocyte-specific expression of bacterial nitroreductase to cause temporally controlled liver damage. A whole organism-based chemical screen using the transgenic line identified BML-257, a potent small molecule AKT inhibitor, that protected the liver against metronidazole-induced liver injury. BML-257 also showed potent prophylactic and pro-regenerative activity in this liver damage model. BML-257 was tested in two independent toxicological models of liver injury caused by acetaminophen and isoniazid and was found to be protective against damage. This suggests that BML-257 has the potential to protect against multiple kinds of DILI." @default.
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- W4284683238 date "2022-07-07" @default.
- W4284683238 modified "2023-10-17" @default.
- W4284683238 title "BML-257, a Small Molecule that Protects against Drug-Induced Liver Injury in Zebrafish" @default.
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- W4284683238 doi "https://doi.org/10.1021/acs.chemrestox.2c00100" @default.
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