Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284683442> ?p ?o ?g. }
- W4284683442 abstract "Abstract Objective Long INterspersed Element-1 (L1) is an autonomous transposable element in the genome. L1 transcripts that are not reverse transcribed back into the genome can accumulate in the cytoplasm and activate an inflammatory response via the cyclic GMP-AMP (cGAS)-STING pathway. We examined skeletal muscle L1 markers as well as STING protein levels in 10 older individuals (63 ± 11 y, BMI = 30.2 ± 6.8 kg/m 2 ) with end-stage osteoarthritis (OA) undergoing total hip (THA, n = 4) or knee (TKA, n = 6) arthroplasty versus 10 young, healthy comparators (Y, 22 ± 2 y, BMI = 23.2 ± 2.5 kg/m 2 ). For OA, muscle was collected from surgical (SX) and contralateral (CTL) sides whereas single vastus lateralis samples were collected from Y. Results L1 mRNA was higher in CTL and SX compared to Y (p < 0.001 and p = 0.001, respectively). Protein expression was higher in SX versus Y for ORF1p (p = 0.002) and STING (p = 0.022). While these data are preliminary due to limited n-sizes and the lack of a BMI-matched younger control group, higher L1 mRNA expression, ORF1p and STING protein are evident in older versus younger adults. More research is needed to determine whether cGAS-STING signaling contributes to heightened muscle inflammation during aging and/or OA." @default.
- W4284683442 created "2022-07-08" @default.
- W4284683442 creator A5034450751 @default.
- W4284683442 creator A5042293246 @default.
- W4284683442 creator A5045516805 @default.
- W4284683442 creator A5046461621 @default.
- W4284683442 creator A5056822869 @default.
- W4284683442 creator A5058873829 @default.
- W4284683442 creator A5069158768 @default.
- W4284683442 creator A5074859611 @default.
- W4284683442 creator A5075576544 @default.
- W4284683442 creator A5090731148 @default.
- W4284683442 date "2022-07-07" @default.
- W4284683442 modified "2023-10-14" @default.
- W4284683442 title "Effects of end-stage osteoarthritis on markers of skeletal muscle Long INterspersed Element-1 activity" @default.
- W4284683442 cites W1412166937 @default.
- W4284683442 cites W1986319478 @default.
- W4284683442 cites W1999494370 @default.
- W4284683442 cites W2007589425 @default.
- W4284683442 cites W2059864757 @default.
- W4284683442 cites W2063898216 @default.
- W4284683442 cites W2076699592 @default.
- W4284683442 cites W2102773855 @default.
- W4284683442 cites W2114766453 @default.
- W4284683442 cites W2120277368 @default.
- W4284683442 cites W2121659762 @default.
- W4284683442 cites W2122107066 @default.
- W4284683442 cites W2131212168 @default.
- W4284683442 cites W2150453771 @default.
- W4284683442 cites W2168909179 @default.
- W4284683442 cites W2612486594 @default.
- W4284683442 cites W2790220021 @default.
- W4284683442 cites W2911642321 @default.
- W4284683442 cites W2921681769 @default.
- W4284683442 cites W2945993260 @default.
- W4284683442 cites W2949097337 @default.
- W4284683442 cites W2952942422 @default.
- W4284683442 cites W2966372761 @default.
- W4284683442 cites W3003405284 @default.
- W4284683442 cites W4214834411 @default.
- W4284683442 cites W4248592944 @default.
- W4284683442 doi "https://doi.org/10.1186/s13104-022-06113-0" @default.
- W4284683442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35799274" @default.
- W4284683442 hasPublicationYear "2022" @default.
- W4284683442 type Work @default.
- W4284683442 citedByCount "1" @default.
- W4284683442 countsByYear W42846834422022 @default.
- W4284683442 crossrefType "journal-article" @default.
- W4284683442 hasAuthorship W4284683442A5034450751 @default.
- W4284683442 hasAuthorship W4284683442A5042293246 @default.
- W4284683442 hasAuthorship W4284683442A5045516805 @default.
- W4284683442 hasAuthorship W4284683442A5046461621 @default.
- W4284683442 hasAuthorship W4284683442A5056822869 @default.
- W4284683442 hasAuthorship W4284683442A5058873829 @default.
- W4284683442 hasAuthorship W4284683442A5069158768 @default.
- W4284683442 hasAuthorship W4284683442A5074859611 @default.
- W4284683442 hasAuthorship W4284683442A5075576544 @default.
- W4284683442 hasAuthorship W4284683442A5090731148 @default.
- W4284683442 hasBestOaLocation W42846834421 @default.
- W4284683442 hasConcept C126322002 @default.
- W4284683442 hasConcept C127413603 @default.
- W4284683442 hasConcept C134018914 @default.
- W4284683442 hasConcept C142724271 @default.
- W4284683442 hasConcept C146978453 @default.
- W4284683442 hasConcept C204787440 @default.
- W4284683442 hasConcept C2776164576 @default.
- W4284683442 hasConcept C2776643329 @default.
- W4284683442 hasConcept C2776914184 @default.
- W4284683442 hasConcept C2779300339 @default.
- W4284683442 hasConcept C2779959927 @default.
- W4284683442 hasConcept C71924100 @default.
- W4284683442 hasConceptScore W4284683442C126322002 @default.
- W4284683442 hasConceptScore W4284683442C127413603 @default.
- W4284683442 hasConceptScore W4284683442C134018914 @default.
- W4284683442 hasConceptScore W4284683442C142724271 @default.
- W4284683442 hasConceptScore W4284683442C146978453 @default.
- W4284683442 hasConceptScore W4284683442C204787440 @default.
- W4284683442 hasConceptScore W4284683442C2776164576 @default.
- W4284683442 hasConceptScore W4284683442C2776643329 @default.
- W4284683442 hasConceptScore W4284683442C2776914184 @default.
- W4284683442 hasConceptScore W4284683442C2779300339 @default.
- W4284683442 hasConceptScore W4284683442C2779959927 @default.
- W4284683442 hasConceptScore W4284683442C71924100 @default.
- W4284683442 hasFunder F4320332161 @default.
- W4284683442 hasIssue "1" @default.
- W4284683442 hasLocation W42846834421 @default.
- W4284683442 hasLocation W42846834422 @default.
- W4284683442 hasLocation W42846834423 @default.
- W4284683442 hasLocation W42846834424 @default.
- W4284683442 hasOpenAccess W4284683442 @default.
- W4284683442 hasPrimaryLocation W42846834421 @default.
- W4284683442 hasRelatedWork W1974568996 @default.
- W4284683442 hasRelatedWork W2016840789 @default.
- W4284683442 hasRelatedWork W2048328229 @default.
- W4284683442 hasRelatedWork W2081376013 @default.
- W4284683442 hasRelatedWork W2144576666 @default.
- W4284683442 hasRelatedWork W2309978229 @default.
- W4284683442 hasRelatedWork W2463478234 @default.
- W4284683442 hasRelatedWork W3032853368 @default.
- W4284683442 hasRelatedWork W4383602876 @default.