Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284684013> ?p ?o ?g. }
- W4284684013 endingPage "105230" @default.
- W4284684013 startingPage "105230" @default.
- W4284684013 abstract "It is widely known that GnRH plays a role in facilitating reproductive function via the HPG axis, and this was once believed to be its only function. However, over the last several decades important neuromodulatory roles of GnRH in multiple brain functions have been elucidated. Multiple GnRH isoforms and receptors have been detected outside the HPG-axis across different species. In this review, we focus on the human CNS where GnRH I and II isoforms and a functional GnRH I receptor have been isolated. We first describe the traditional understanding of GnRH within the hypothalamus and the pituitary and current clinical use of GnRH analogues. We then review the location and function of GnRH-producing neurons and receptors located outside the HPG axis. We next review the GnRH I and II neuron location and quantity and GnRH I receptor gene expression throughout the human brain, using the Allen Brain Map Atlas. This analysis demonstrates a wide expression of GnRH throughout the brain, including prominent expression in the basal forebrain and cerebellum. Lastly, we examine the potential role of GnRH in aging and inflammation and its therapeutic potential for neurodegenerative disease and spinal cord lesions." @default.
- W4284684013 created "2022-07-08" @default.
- W4284684013 creator A5038297709 @default.
- W4284684013 creator A5041689299 @default.
- W4284684013 creator A5055979380 @default.
- W4284684013 creator A5067709976 @default.
- W4284684013 date "2022-09-01" @default.
- W4284684013 modified "2023-10-16" @default.
- W4284684013 title "The roles of GnRH in the human central nervous system" @default.
- W4284684013 cites W1590406234 @default.
- W4284684013 cites W1603023934 @default.
- W4284684013 cites W1969107279 @default.
- W4284684013 cites W1973571827 @default.
- W4284684013 cites W1976985571 @default.
- W4284684013 cites W1977515570 @default.
- W4284684013 cites W1977816764 @default.
- W4284684013 cites W1986110768 @default.
- W4284684013 cites W1989652277 @default.
- W4284684013 cites W1991847642 @default.
- W4284684013 cites W1994954453 @default.
- W4284684013 cites W1999810295 @default.
- W4284684013 cites W2003845868 @default.
- W4284684013 cites W2005161082 @default.
- W4284684013 cites W2005438338 @default.
- W4284684013 cites W2006081278 @default.
- W4284684013 cites W2015390387 @default.
- W4284684013 cites W2021354355 @default.
- W4284684013 cites W2021364293 @default.
- W4284684013 cites W2022479818 @default.
- W4284684013 cites W2023168194 @default.
- W4284684013 cites W2023979852 @default.
- W4284684013 cites W2024205731 @default.
- W4284684013 cites W2024814110 @default.
- W4284684013 cites W2027421516 @default.
- W4284684013 cites W2028396047 @default.
- W4284684013 cites W2029222763 @default.
- W4284684013 cites W2029618197 @default.
- W4284684013 cites W2030002742 @default.
- W4284684013 cites W2037265353 @default.
- W4284684013 cites W2038028323 @default.
- W4284684013 cites W2039198739 @default.
- W4284684013 cites W2041302987 @default.
- W4284684013 cites W2044723567 @default.
- W4284684013 cites W2045682412 @default.
- W4284684013 cites W2046382472 @default.
- W4284684013 cites W2054728846 @default.
- W4284684013 cites W2055090365 @default.
- W4284684013 cites W2061602086 @default.
- W4284684013 cites W2067674574 @default.
- W4284684013 cites W2072685254 @default.
- W4284684013 cites W2078621304 @default.
- W4284684013 cites W2082899029 @default.
- W4284684013 cites W2084467580 @default.
- W4284684013 cites W2085998115 @default.
- W4284684013 cites W2087935048 @default.
- W4284684013 cites W2089670528 @default.
- W4284684013 cites W2090977762 @default.
- W4284684013 cites W2093613378 @default.
- W4284684013 cites W2094742992 @default.
- W4284684013 cites W2098009444 @default.
- W4284684013 cites W2099659064 @default.
- W4284684013 cites W2100978216 @default.
- W4284684013 cites W2116463788 @default.
- W4284684013 cites W2127673211 @default.
- W4284684013 cites W2130784408 @default.
- W4284684013 cites W2130978648 @default.
- W4284684013 cites W2131769837 @default.
- W4284684013 cites W2138742126 @default.
- W4284684013 cites W2140475850 @default.
- W4284684013 cites W2141582604 @default.
- W4284684013 cites W2143506157 @default.
- W4284684013 cites W2146525281 @default.
- W4284684013 cites W2151613225 @default.
- W4284684013 cites W2153083446 @default.
- W4284684013 cites W2154153850 @default.
- W4284684013 cites W2155846608 @default.
- W4284684013 cites W2160764439 @default.
- W4284684013 cites W2322475390 @default.
- W4284684013 cites W2336708886 @default.
- W4284684013 cites W2352030796 @default.
- W4284684013 cites W2409593680 @default.
- W4284684013 cites W2409949928 @default.
- W4284684013 cites W2444148625 @default.
- W4284684013 cites W2504724155 @default.
- W4284684013 cites W2547519480 @default.
- W4284684013 cites W2602426636 @default.
- W4284684013 cites W2765987013 @default.
- W4284684013 cites W2773934670 @default.
- W4284684013 cites W2792111219 @default.
- W4284684013 cites W2914454597 @default.
- W4284684013 cites W2944566833 @default.
- W4284684013 cites W2970013860 @default.
- W4284684013 cites W3014849785 @default.
- W4284684013 cites W3049667945 @default.
- W4284684013 cites W3100160405 @default.
- W4284684013 cites W3103856094 @default.
- W4284684013 cites W3169840262 @default.
- W4284684013 cites W3176020418 @default.