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• W4284685532 endingPage "7459" @default.
• W4284685532 startingPage "7459" @default.
• W4284685532 abstract "Ubiquitin (ub) is a small, highly conserved protein widely expressed in eukaryotic cells. Ubiquitination is a post-translational modification catalyzed by enzymes that activate, conjugate, and ligate ub to proteins. Substrates can be modified either by addition of a single ubiquitin molecule (monoubiquitination), or by conjugation of several ubs (polyubiquitination). Monoubiquitination acts as a signaling mark to control diverse biological processes. The cellular and spatial distribution of ub is determined by the opposing activities of ub ligase enzymes, and deubiquitinases (DUBs), which remove ub from proteins to generate free ub. In mammalian cells, 1–2% of total histone H2B is monoubiquitinated. The SAGA (Spt Ada Gcn5 Acetyl-transferase) is a transcriptional coactivator and its DUB module removes ub from H2Bub1. The mammalian SAGA DUB module has four subunits, ATXN7, ATXN7L3, USP22, and ENY2. Atxn7l3−/− mouse embryos, lacking DUB activity, have a five-fold increase in H2Bub1 retention, and die at mid-gestation. Interestingly, embryos lacking the ub encoding gene, Ubc, have a similar phenotype. Here we provide a current overview of data suggesting that H2Bub1 retention on the chromatin in Atxn7l3−/− embryos may lead to an imbalance in free ub distribution. Thus, we speculate that ATXN7L3-containing DUBs impact the free cellular ub pool during development." @default.
• W4284685532 created "2022-07-08" @default.
• W4284685532 creator A5017404099 @default.
• W4284685532 creator A5038523289 @default.
• W4284685532 creator A5059210191 @default.
• W4284685532 creator A5061782826 @default.
• W4284685532 creator A5071643873 @default.
• W4284685532 date "2022-07-05" @default.
• W4284685532 modified "2023-10-18" @default.
• W4284685532 title "SAGA-Dependent Histone H2Bub1 Deubiquitination Is Essential for Cellular Ubiquitin Balance during Embryonic Development" @default.
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• W4284685532 doi "https://doi.org/10.3390/ijms23137459" @default.
• W4284685532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35806465" @default.
• W4284685532 hasPublicationYear "2022" @default.
• W4284685532 type Work @default.
• W4284685532 citedByCount "3" @default.

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