FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284686957> ?p ?o ?g. }

• W4284686957 endingPage "633" @default.
• W4284686957 startingPage "623" @default.
• W4284686957 abstract "Cardiovascular diseases account for most of the morbidity and mortality associated with diabetes. Diabetic cardiomyopathy (DCM) is associated with heart failure in diabetic patients without relation to other cardiovascular diseases such as hypertension or coronary artery disorders. Eugenol is a phenolic compound extracted from the clove tree and exhibits effective mitigation of hyperglycemic conditions in diabetic animals. Thus, in the current study, we aimed to explore the effect of eugenol treatment on rats with DCM. The experimental animals included 30 Sprague Dawley male rats which are divided into three experimental groups (10 rats each) as the following: the non-diabetic control group (ND), diabetic group (D), and a treated-diabetic group (20mg/kg/day of eugenol) (D+E). Diabetes was induced by streptozotocin (STZ) injection (60 mg/ kg). After 6 weeks, blood samples and left ventricles were collected for analysis. Serum glucose levels, heart weight/body weight ratio, and the myocardial mRNA expression of transforming growth factor β1 (TGF-β1), tumor necrosis factor-α (TNF-α), caspase 3 (casp3), vascular endothelial growth factor-A (VEGF-A), and collagen IV were evaluated. Furthermore, the myocardial superoxide dismutase (SOD) activity was measured. Diabetic rats showed a significant appearance of hyperglycemia and increased expression of myocardial TNF-α, TGF-β1, caspase 3, and VEGF-A compared to the control group (P < 0.05), and a tendency to increase collagen IV (P < 0.1). On the other hand, the eugenol treatment mitigates diabetic-associated hyperglycemia and the increased mRNA expression levels of myocardial TGF-β1, VEGF-A, caspase 3, and TNF-α (P < 0.05). In addition, the overexpression of collagen IV was inhibited, and the myocardial SOD activity was improved in the diabetic rats treated with eugenol. The study provided evidence that eugenol may have a potential therapeutic effect in the experimental models of DCM by reducing the expression of pro-inflammatory, pro-fibrotic, angiogenic, and pro-apoptotic factors (TNF-α, TGF-β, collagen IV, VEGF-A, and caspase 3 respectively). It is recommended for further studies investigate the exact molecular processes by which eugenol may ameliorate the DCM phenotype." @default.
• W4284686957 created "2022-07-08" @default.
• W4284686957 creator A5005566587 @default.
• W4284686957 creator A5025357773 @default.
• W4284686957 creator A5032917867 @default.
• W4284686957 creator A5047869985 @default.
• W4284686957 creator A5064362708 @default.
• W4284686957 creator A5082765873 @default.
• W4284686957 date "2022-06-30" @default.
• W4284686957 modified "2023-09-30" @default.
• W4284686957 title "The Effect of Eugenol Treatment on Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats" @default.
• W4284686957 cites W1967625924 @default.
• W4284686957 cites W1989101440 @default.
• W4284686957 cites W1990746160 @default.
• W4284686957 cites W1995199032 @default.
• W4284686957 cites W2007634515 @default.
• W4284686957 cites W2023082526 @default.
• W4284686957 cites W2027210863 @default.
• W4284686957 cites W2030549657 @default.
• W4284686957 cites W2043582528 @default.
• W4284686957 cites W2045824542 @default.
• W4284686957 cites W2050517931 @default.
• W4284686957 cites W2051131221 @default.
• W4284686957 cites W2097056441 @default.
• W4284686957 cites W2098270306 @default.
• W4284686957 cites W2101508556 @default.
• W4284686957 cites W2120293565 @default.
• W4284686957 cites W2132250523 @default.
• W4284686957 cites W2145946836 @default.
• W4284686957 cites W2146302436 @default.
• W4284686957 cites W2153092921 @default.
• W4284686957 cites W2164819262 @default.
• W4284686957 cites W2175646667 @default.
• W4284686957 cites W2225072053 @default.
• W4284686957 cites W2337276748 @default.
• W4284686957 cites W2416650079 @default.
• W4284686957 cites W2591558322 @default.
• W4284686957 cites W2592071158 @default.
• W4284686957 cites W2606577905 @default.
• W4284686957 cites W2610708450 @default.
• W4284686957 cites W2741233771 @default.
• W4284686957 cites W2752706970 @default.
• W4284686957 cites W2768331948 @default.
• W4284686957 cites W2768499679 @default.
• W4284686957 cites W2790947206 @default.
• W4284686957 cites W2791517164 @default.
• W4284686957 cites W2792805849 @default.
• W4284686957 cites W2795534327 @default.
• W4284686957 cites W2806521060 @default.
• W4284686957 cites W2806804137 @default.
• W4284686957 cites W2886140532 @default.
• W4284686957 cites W2901508016 @default.
• W4284686957 cites W2903562879 @default.
• W4284686957 cites W2923081711 @default.
• W4284686957 cites W2937176927 @default.
• W4284686957 cites W2939633281 @default.
• W4284686957 cites W2940275338 @default.
• W4284686957 cites W2954531847 @default.
• W4284686957 cites W2981414744 @default.
• W4284686957 cites W2988345283 @default.
• W4284686957 cites W2989129508 @default.
• W4284686957 cites W2992675545 @default.
• W4284686957 cites W3005113782 @default.
• W4284686957 cites W3007757041 @default.
• W4284686957 cites W3012814323 @default.
• W4284686957 cites W3021622752 @default.
• W4284686957 cites W3080581218 @default.
• W4284686957 cites W3092363281 @default.
• W4284686957 cites W3093443532 @default.
• W4284686957 cites W3157906588 @default.
• W4284686957 cites W3165727437 @default.
• W4284686957 cites W3173612353 @default.
• W4284686957 cites W3195156895 @default.
• W4284686957 cites W3201943150 @default.
• W4284686957 cites W4206815251 @default.
• W4284686957 cites W4225824260 @default.
• W4284686957 cites W4240920381 @default.
• W4284686957 cites W4249341602 @default.
• W4284686957 doi "https://doi.org/10.13005/bpj/2401" @default.
• W4284686957 hasPublicationYear "2022" @default.
• W4284686957 type Work @default.
• W4284686957 citedByCount "0" @default.
• W4284686957 crossrefType "journal-article" @default.
• W4284686957 hasAuthorship W4284686957A5005566587 @default.
• W4284686957 hasAuthorship W4284686957A5025357773 @default.
• W4284686957 hasAuthorship W4284686957A5032917867 @default.
• W4284686957 hasAuthorship W4284686957A5047869985 @default.
• W4284686957 hasAuthorship W4284686957A5064362708 @default.
• W4284686957 hasAuthorship W4284686957A5082765873 @default.
• W4284686957 hasBestOaLocation W42846869571 @default.
• W4284686957 hasConcept C118131993 @default.
• W4284686957 hasConcept C126322002 @default.
• W4284686957 hasConcept C134018914 @default.
• W4284686957 hasConcept C167734588 @default.
• W4284686957 hasConcept C178790620 @default.
• W4284686957 hasConcept C185592680 @default.
• W4284686957 hasConcept C2776553924 @default.
• W4284686957 hasConcept C2777025900 @default.

• next