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- W4284687400 abstract "Immunocyte migration to infection sites is important for host cellular defense, but the main types of migrating hemocytes and their mechanisms against pathogen invasions are unclear in invertebrates. In the present study, a population of hemocytes in the Pacific oyster Crassostrea gigas labeled with a fluorescein isothiocyanate (FITC)-conjugated Arg-Gly-Asp (RGD)-containing peptide was sorted. RGD+ hemocytes were characterized by a smaller cell size and cytoplasmic-nucleo ratio, fewer cytoplasmic granules, and higher levels of myeloperoxidase, reactive oxygen species, and intracellular free calcium concentration. RGD+ hemocytes exhibited a high level of migration activity, which was further induced after V. splendidus infection. Transcriptome analysis revealed that RGD+ hemocytes highly expressed a series of migration-related genes, which together with migration-promoting genes were significantly upregulated after V. splendidus infection. The neuroendocrine system was also proven to regulate the migration activity of RGD+ hemocytes, especially with the excitatory neuroendocrine factor dopamine, which promoted migration activity as confirmed by receptor blocking assays. Meanwhile, RGD+ hemocytes could highly express immunomodulatory factor interleukin (IL)-17s and their receptor genes, which was positively related to the production of antimicrobial peptides in whole hemocytes after V. splendidus infection. Collectively, this study identified a specific hemocyte population, i.e., RGD+ hemocytes, that shows high migration activity in response to pathogen infection and exerts a potential immunomodulatory role by highly expressing IL-17s that might enhance the hemocytes' antimicrobial peptide production in oysters." @default.
- W4284687400 created "2022-07-08" @default.
- W4284687400 creator A5002461253 @default.
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- W4284687400 creator A5050964192 @default.
- W4284687400 date "2022-07-05" @default.
- W4284687400 modified "2023-10-16" @default.
- W4284687400 title "RGD-Labeled Hemocytes With High Migration Activity Display a Potential Immunomodulatory Role in the Pacific Oyster Crassostrea gigas" @default.
- W4284687400 cites W1535842809 @default.
- W4284687400 cites W1576773659 @default.
- W4284687400 cites W1908815970 @default.
- W4284687400 cites W1973639818 @default.
- W4284687400 cites W1978172618 @default.
- W4284687400 cites W1979346765 @default.
- W4284687400 cites W1983085370 @default.
- W4284687400 cites W1987820786 @default.
- W4284687400 cites W1989599722 @default.
- W4284687400 cites W1994757111 @default.
- W4284687400 cites W1995915983 @default.
- W4284687400 cites W2020750760 @default.
- W4284687400 cites W2024677782 @default.
- W4284687400 cites W2026345779 @default.
- W4284687400 cites W2029039883 @default.
- W4284687400 cites W2029356220 @default.
- W4284687400 cites W2030029307 @default.
- W4284687400 cites W2031412549 @default.
- W4284687400 cites W2035892830 @default.
- W4284687400 cites W2037911414 @default.
- W4284687400 cites W2038678974 @default.
- W4284687400 cites W2038731722 @default.
- W4284687400 cites W2051179336 @default.
- W4284687400 cites W2056000786 @default.
- W4284687400 cites W2056573980 @default.
- W4284687400 cites W2059135275 @default.
- W4284687400 cites W2060822835 @default.
- W4284687400 cites W2065368736 @default.
- W4284687400 cites W2066515050 @default.
- W4284687400 cites W2068184022 @default.
- W4284687400 cites W2074964253 @default.
- W4284687400 cites W2076717151 @default.
- W4284687400 cites W2079595896 @default.
- W4284687400 cites W2083311984 @default.
- W4284687400 cites W2093897672 @default.
- W4284687400 cites W2107277218 @default.
- W4284687400 cites W2110065044 @default.
- W4284687400 cites W2111759307 @default.
- W4284687400 cites W2116516945 @default.
- W4284687400 cites W2119034410 @default.
- W4284687400 cites W2123326379 @default.
- W4284687400 cites W2132936019 @default.
- W4284687400 cites W2134051754 @default.
- W4284687400 cites W2144588212 @default.
- W4284687400 cites W2152462023 @default.
- W4284687400 cites W2154465669 @default.
- W4284687400 cites W2156264579 @default.
- W4284687400 cites W2158217645 @default.
- W4284687400 cites W2159391328 @default.
- W4284687400 cites W2159482845 @default.
- W4284687400 cites W2163180789 @default.
- W4284687400 cites W2172160601 @default.
- W4284687400 cites W2192080449 @default.
- W4284687400 cites W2194237486 @default.
- W4284687400 cites W2203346077 @default.
- W4284687400 cites W2267931422 @default.
- W4284687400 cites W2294015452 @default.
- W4284687400 cites W2295394642 @default.
- W4284687400 cites W2402708657 @default.
- W4284687400 cites W2409685932 @default.
- W4284687400 cites W2470321364 @default.
- W4284687400 cites W2512404043 @default.
- W4284687400 cites W2527075345 @default.
- W4284687400 cites W2550932225 @default.
- W4284687400 cites W2575070913 @default.
- W4284687400 cites W2588811771 @default.
- W4284687400 cites W2597595800 @default.
- W4284687400 cites W2620889645 @default.
- W4284687400 cites W2743481635 @default.
- W4284687400 cites W2755248841 @default.
- W4284687400 cites W2792809997 @default.
- W4284687400 cites W2803501913 @default.
- W4284687400 cites W2888455562 @default.
- W4284687400 cites W2891539047 @default.
- W4284687400 cites W2892039614 @default.
- W4284687400 cites W2894768040 @default.
- W4284687400 cites W2900713613 @default.
- W4284687400 cites W2911779066 @default.
- W4284687400 cites W2944496025 @default.
- W4284687400 cites W2971730418 @default.
- W4284687400 cites W2979332239 @default.
- W4284687400 cites W2985961783 @default.
- W4284687400 cites W3011593562 @default.
- W4284687400 cites W3044322347 @default.
- W4284687400 cites W3139201493 @default.
- W4284687400 cites W3167390221 @default.
- W4284687400 cites W4211233832 @default.
- W4284687400 cites W4213326004 @default.