FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284687586> ?p ?o ?g. }

• W4284687586 abstract "Anti-glomerular basement membrane (anti-GBM) disease is a severe entity with few therapeutic options including plasma exchange and immunosuppressive agents. The aim of this study was to analyze the clinical and pathological features that predict the evolution of end-stage kidney disease (ESKD) and the kidney survival in a cohort of patients with anti-GBM disease with renal involvement in real life.A retrospective multicentre observational study including 72 patients from 18 nephrology departments with biopsy-proven anti-GBM disease from 1999 to 2019 was performed. Progression to ESKD in relation to clinical and histological variables was evaluated.Creatinine at admission was 8.6 (± 4) mg/dL and 61 patients (84.7%) required dialysis. Sixty-five patients (90.3%) underwent plasma exchange. Twenty-two patients (30.6%) presented pulmonary hemorrhage. Kidney survival was worse in patients with creatinine levels > 4.7 mg/dL (3 vs. 44% p < 0.01) and in patients with > 50% crescents (6 vs. 49%; p = 0.03). Dialysis dependence at admission and creatinine levels > 4.7 mg/dL remained independent significant predictors of ESKD in the multivariable analysis [HR (hazard ratio) 3.13 (1.25-7.84); HR 3 (1.01-9.14); p < 0.01]. The discrimination value for a creatinine level > 4.7 mg/dL and 50.5% crescents had an area under the curve (AUC) of 0.9 (95% CI 0.82-0.97; p < 0.001) and 0.77 (95% CI 0.56-0.98; p = 0.008), respectively. Kidney survival at 1 and 2 years was 13.5 and 11%, respectively. Patient survival at 5 years was 81%.In real life, patients with severe anti-GBM disease (creatinine > 4.7 mg/dL and > 50% crescents) remained with devastating renal prognosis despite plasma exchange and immunosuppressive treatment. New therapies for the treatment of this rare renal disease are urgently needed." @default.
• W4284687586 created "2022-07-08" @default.
• W4284687586 creator A5001003063 @default.
• W4284687586 creator A5008335410 @default.
• W4284687586 creator A5015779549 @default.
• W4284687586 creator A5018789658 @default.
• W4284687586 creator A5019581349 @default.
• W4284687586 creator A5029611097 @default.
• W4284687586 creator A5030567793 @default.
• W4284687586 creator A5036682781 @default.
• W4284687586 creator A5044443091 @default.
• W4284687586 creator A5045655494 @default.
• W4284687586 creator A5046757963 @default.
• W4284687586 creator A5046852623 @default.
• W4284687586 creator A5048784225 @default.
• W4284687586 creator A5058915625 @default.
• W4284687586 creator A5071593060 @default.
• W4284687586 creator A5072040396 @default.
• W4284687586 creator A5077324980 @default.
• W4284687586 creator A5080926563 @default.
• W4284687586 creator A5082075817 @default.
• W4284687586 date "2022-07-05" @default.
• W4284687586 modified "2023-10-18" @default.
• W4284687586 title "Anti-glomerular Basement Membrane Glomerulonephritis: A Study in Real Life" @default.
• W4284687586 cites W125031658 @default.
• W4284687586 cites W1919415743 @default.
• W4284687586 cites W1970345179 @default.
• W4284687586 cites W1990281400 @default.
• W4284687586 cites W2019828059 @default.
• W4284687586 cites W2023277595 @default.
• W4284687586 cites W2038837815 @default.
• W4284687586 cites W2039169783 @default.
• W4284687586 cites W2039674319 @default.
• W4284687586 cites W2042031358 @default.
• W4284687586 cites W2047080292 @default.
• W4284687586 cites W2066354869 @default.
• W4284687586 cites W2085892570 @default.
• W4284687586 cites W2087509528 @default.
• W4284687586 cites W2120337859 @default.
• W4284687586 cites W2122611620 @default.
• W4284687586 cites W2135792553 @default.
• W4284687586 cites W2158595140 @default.
• W4284687586 cites W2169537329 @default.
• W4284687586 cites W2275867151 @default.
• W4284687586 cites W2409796292 @default.
• W4284687586 cites W2472545716 @default.
• W4284687586 cites W2610050121 @default.
• W4284687586 cites W2613744835 @default.
• W4284687586 cites W2614646425 @default.
• W4284687586 cites W2769849869 @default.
• W4284687586 cites W340921193 @default.
• W4284687586 cites W53739053 @default.
• W4284687586 doi "https://doi.org/10.3389/fmed.2022.889185" @default.
• W4284687586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35865174" @default.
• W4284687586 hasPublicationYear "2022" @default.
• W4284687586 type Work @default.
• W4284687586 citedByCount "4" @default.
• W4284687586 countsByYear W42846875862022 @default.
• W4284687586 countsByYear W42846875862023 @default.
• W4284687586 crossrefType "journal-article" @default.
• W4284687586 hasAuthorship W4284687586A5001003063 @default.
• W4284687586 hasAuthorship W4284687586A5008335410 @default.
• W4284687586 hasAuthorship W4284687586A5015779549 @default.
• W4284687586 hasAuthorship W4284687586A5018789658 @default.
• W4284687586 hasAuthorship W4284687586A5019581349 @default.
• W4284687586 hasAuthorship W4284687586A5029611097 @default.
• W4284687586 hasAuthorship W4284687586A5030567793 @default.
• W4284687586 hasAuthorship W4284687586A5036682781 @default.
• W4284687586 hasAuthorship W4284687586A5044443091 @default.
• W4284687586 hasAuthorship W4284687586A5045655494 @default.
• W4284687586 hasAuthorship W4284687586A5046757963 @default.
• W4284687586 hasAuthorship W4284687586A5046852623 @default.
• W4284687586 hasAuthorship W4284687586A5048784225 @default.
• W4284687586 hasAuthorship W4284687586A5058915625 @default.
• W4284687586 hasAuthorship W4284687586A5071593060 @default.
• W4284687586 hasAuthorship W4284687586A5072040396 @default.
• W4284687586 hasAuthorship W4284687586A5077324980 @default.
• W4284687586 hasAuthorship W4284687586A5080926563 @default.
• W4284687586 hasAuthorship W4284687586A5082075817 @default.
• W4284687586 hasBestOaLocation W42846875861 @default.
• W4284687586 hasConcept C126322002 @default.
• W4284687586 hasConcept C126894567 @default.
• W4284687586 hasConcept C159641895 @default.
• W4284687586 hasConcept C167135981 @default.
• W4284687586 hasConcept C207103383 @default.
• W4284687586 hasConcept C2775998817 @default.
• W4284687586 hasConcept C2778063415 @default.
• W4284687586 hasConcept C2778653478 @default.
• W4284687586 hasConcept C2779978075 @default.
• W4284687586 hasConcept C2780091579 @default.
• W4284687586 hasConcept C2780306776 @default.
• W4284687586 hasConcept C2780368995 @default.
• W4284687586 hasConcept C44249647 @default.
• W4284687586 hasConcept C54847362 @default.
• W4284687586 hasConcept C71924100 @default.
• W4284687586 hasConcept C90924648 @default.
• W4284687586 hasConceptScore W4284687586C126322002 @default.
• W4284687586 hasConceptScore W4284687586C126894567 @default.
• W4284687586 hasConceptScore W4284687586C159641895 @default.
• W4284687586 hasConceptScore W4284687586C167135981 @default.

• next