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- W4284687908 abstract "Abstract Background and purpose: Dyskinesia is a series of movement disorders arising from a stroke. Western medicine focuses on anticoagulation, which can lead to intracranial and gastrointestinal bleeding, and reduce the body's immunity. Traditional therapies including acupuncture, tuina, and Chinese herbs, etc., works slowly as well as the relatively simple efficacy. The triple facilitation therapy, an integrated rehabilitation therapy of Traditional Chinese and Western Medicine, consisting of Lee's pestle needle therapy, Du’s massage therapy, and functional exercise, has effects on improving muscle strength, reducing muscle tension, and assisting in establishing normal movement patterns according to a pilot trial. Whether the triple facilitation therapy is superior to Zhongfengxingnao Oral Liquid, a commonly used Chinese patent medicine in dyskinesia patients after stroke remains unclear. This study aims to compare the effect and safety of triple facilitation therapy and Zhongfengxingnao oral liquid in improving motor function and quality of life in post-stroke dyskinesia patients, and to further verify the non-inferiority of the triple facilitation therapy. Methods and analysis: This study is a randomized-controlled, single-blind trial of triple facilitation therapy (n=33) versus Zhongfengxingnao oral liquid (n=33) in the non-acute stage of post-stroke dyskinesia patients. MMT freehand muscle strength grading, modified Ashworth grading, simplified Fugl-Meyer scoring, isokinetic muscle test outcomes, and 3-D gait analysis outcomes are the primary outcomes. The secondary outcomes include ADL/disability (FIM), general indexes, biochemical indexes, and adverse events. All the primary and secondary outcomes will be assessed at baseline (1 day) and 4-weeks/post-intervention (28 days). This study will confirm whether triple facilitation therapy improves rehabilitation of the non-acute stage of post-stroke dyskinesia better than Zhongfengxingnao oral liquid. Ethics and dissemination: Institutional Review Board of the Hospital of Chengdu University of Traditional Chinese Medicine approved the research and will obtain the written informed consent of each subject or representative. Trial registry number : ChiCTR2100045105 (www.chictr.org.cn)" @default.
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- W4284687908 date "2022-07-05" @default.
- W4284687908 modified "2023-09-29" @default.
- W4284687908 title "Triple facilitation therapy in the non-acute stage of post-stroke dyskinesia: protocol for a single-blind randomized controlled trial" @default.
- W4284687908 doi "https://doi.org/10.21203/rs.3.rs-1719063/v1" @default.
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