FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284688718> ?p ?o ?g. }

• W4284688718 abstract "Sepsis is defined as a life-threatening organ dysfunction caused by an inappropriate host response to infection. The presence of oxidative stress and inflammatory mediators in sepsis leads to dysregulated gene expression, leading to a hyperinflammatory response. Environmental conditions play an important role in various pathologies depending on the stimulus it presents. A standard environment condition (SE) may offer reduced sensory and cognitive stimulation, but an enriched environment improves spatial learning, prevents cognitive deficits induced by disease stress, and is an important modulator of epigenetic enzymes. The study evaluated the epigenetic alterations and the effects of the environmental enrichment (EE) protocol in the brain of animals submitted to sepsis by cecal ligation and perforation (CLP). Male Wistar rats were divided into sham and CLP at 24 h, 72 h, 10 days and 30 days after sepsis. Other male Wistar rats were distributed in a SE or in EE for forty-five days. Behavioral tests, analysis of epigenetic enzymes:histone acetylase (HAT), histone deacetylase (HDAC) and DNA methyltransferase (DNMT), biochemical and synaptic plasticity analyzes were performed. An increase in HDAC and DNMT activities was observed at 72 h, 10 days and 30 days. There was a positive correlation between epigenetic enzymes DNMT and HDAC 24 h, 10 days and 30 days. After EE, HDAC and DNMT enzyme activity decreased, cognitive impairment was reversed, IL1-β levels decreased and there was an increase in PSD-95 levels in the hippocampus. Interventions in environmental conditions can modulate the outcomes of long-term cognitive consequences associated with sepsis, supporting the idea of the potential benefits of EE." @default.
• W4284688718 created "2022-07-08" @default.
• W4284688718 creator A5013900434 @default.
• W4284688718 creator A5026553921 @default.
• W4284688718 creator A5037302251 @default.
• W4284688718 creator A5042403027 @default.
• W4284688718 creator A5045192177 @default.
• W4284688718 creator A5055369872 @default.
• W4284688718 creator A5066680140 @default.
• W4284688718 creator A5067673394 @default.
• W4284688718 creator A5069261806 @default.
• W4284688718 creator A5073569899 @default.
• W4284688718 creator A5073831776 @default.
• W4284688718 creator A5075902539 @default.
• W4284688718 creator A5089983151 @default.
• W4284688718 date "2022-07-07" @default.
• W4284688718 modified "2023-10-14" @default.
• W4284688718 title "Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis" @default.
• W4284688718 cites W1554161393 @default.
• W4284688718 cites W1599712352 @default.
• W4284688718 cites W1613085441 @default.
• W4284688718 cites W1775749144 @default.
• W4284688718 cites W1975365759 @default.
• W4284688718 cites W1977644740 @default.
• W4284688718 cites W1977919654 @default.
• W4284688718 cites W1980034808 @default.
• W4284688718 cites W1983890419 @default.
• W4284688718 cites W1984155824 @default.
• W4284688718 cites W1989063324 @default.
• W4284688718 cites W1990909279 @default.
• W4284688718 cites W1994388155 @default.
• W4284688718 cites W1997751862 @default.
• W4284688718 cites W2004773559 @default.
• W4284688718 cites W2005979363 @default.
• W4284688718 cites W2020173969 @default.
• W4284688718 cites W2020767030 @default.
• W4284688718 cites W2025810143 @default.
• W4284688718 cites W2026999193 @default.
• W4284688718 cites W2040290877 @default.
• W4284688718 cites W2048132100 @default.
• W4284688718 cites W2048359313 @default.
• W4284688718 cites W2049927822 @default.
• W4284688718 cites W2059100079 @default.
• W4284688718 cites W2064899241 @default.
• W4284688718 cites W2068793888 @default.
• W4284688718 cites W2069717852 @default.
• W4284688718 cites W2075878693 @default.
• W4284688718 cites W2076312647 @default.
• W4284688718 cites W2077249217 @default.
• W4284688718 cites W2078028724 @default.
• W4284688718 cites W2081650874 @default.
• W4284688718 cites W2085367027 @default.
• W4284688718 cites W2090076866 @default.
• W4284688718 cites W2100680516 @default.
• W4284688718 cites W2101155068 @default.
• W4284688718 cites W2106693802 @default.
• W4284688718 cites W2110673629 @default.
• W4284688718 cites W2115970654 @default.
• W4284688718 cites W2127506019 @default.
• W4284688718 cites W2131809266 @default.
• W4284688718 cites W2132100172 @default.
• W4284688718 cites W2132152083 @default.
• W4284688718 cites W2145458957 @default.
• W4284688718 cites W2147524392 @default.
• W4284688718 cites W2177940930 @default.
• W4284688718 cites W2274346642 @default.
• W4284688718 cites W2549063978 @default.
• W4284688718 cites W2558691630 @default.
• W4284688718 cites W2598979376 @default.
• W4284688718 cites W2605505009 @default.
• W4284688718 cites W2736648735 @default.
• W4284688718 cites W2760721217 @default.
• W4284688718 cites W2769734955 @default.
• W4284688718 cites W2770893279 @default.
• W4284688718 cites W2795770621 @default.
• W4284688718 cites W2796425517 @default.
• W4284688718 cites W2809330325 @default.
• W4284688718 cites W2889576817 @default.
• W4284688718 cites W2893084251 @default.
• W4284688718 cites W2921665589 @default.
• W4284688718 cites W2938247032 @default.
• W4284688718 cites W2959181289 @default.
• W4284688718 cites W2985127419 @default.
• W4284688718 cites W2988280376 @default.
• W4284688718 cites W3131473360 @default.
• W4284688718 cites W3167748504 @default.
• W4284688718 doi "https://doi.org/10.1038/s41598-022-14660-6" @default.
• W4284688718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35798809" @default.
• W4284688718 hasPublicationYear "2022" @default.
• W4284688718 type Work @default.
• W4284688718 citedByCount "3" @default.
• W4284688718 countsByYear W42846887182023 @default.
• W4284688718 crossrefType "journal-article" @default.
• W4284688718 hasAuthorship W4284688718A5013900434 @default.
• W4284688718 hasAuthorship W4284688718A5026553921 @default.
• W4284688718 hasAuthorship W4284688718A5037302251 @default.
• W4284688718 hasAuthorship W4284688718A5042403027 @default.
• W4284688718 hasAuthorship W4284688718A5045192177 @default.
• W4284688718 hasAuthorship W4284688718A5055369872 @default.
• W4284688718 hasAuthorship W4284688718A5066680140 @default.

• next