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- W4284689849 abstract "Abstract Acanthamoeba species are amoebae commonly found in nature. Acanthamoeba species were classified using the 18S ribosomal RNA gene sequence and have been divided into 23 genotypes called T1-T23 to date. The aim of this study is to compare the osmotolerance and thermotolerance characteristics of Acanthamoeba strains isolated from environmental and keratitis cases among genotype groups, within species with the same genotype, and to evaluate the relationship between pathogenicity in Acanthamoeba strains with T4, T5, T11 and T12 genotypes. In this study, after axenic cultures of 22 Acanthamoeba strains with T4 (Neff, A, B, D, E), T5, T11 and T12 genotypes isolated from clinical and environmental samples, thermotolerance (37°C, 39°C and 41°C) was determined and osmotolerance (0.5, 1 M) tests were performed. As a result; All strains showed growth ability at both 37°C and 0.5 M osmolarity. While all 5 strains isolated from patients with Acanthamoeba keratitis showed growth ability at 37 o C and 0.5 M osmolarity, no growth was detected at 41 o C and 1 M osmolarity. When the tolerance characteristics of the strains with the same genotype were evaluated, the strains with the T5 and T4E genotypes exhibited the same characteristic. When Acanthamoeba strains with T4 genotype were evaluated in general, 31.25% of the strains were found to grow at 39 o C and 6.25% at 41 o C. While the strain with the T11 genotype grew at all temperatures, the strain with the T12 genotype did not grow at 41 o C. According to our research results, we believe that tolerance to 39 o C and 1M mannitol is not an indicator of pathogenicity. In order to clarify this issue, more studies with Acanthamoeba strains are needed." @default.
- W4284689849 created "2022-07-08" @default.
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- W4284689849 date "2022-07-05" @default.
- W4284689849 modified "2023-10-16" @default.
- W4284689849 title "Are Thermotolerant and Osmotolerant Characteristics of Acanthamoeba Species an Indicator of Pathogenicity?" @default.
- W4284689849 doi "https://doi.org/10.21203/rs.3.rs-1724089/v1" @default.
- W4284689849 hasPublicationYear "2022" @default.
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