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- W4284693043 abstract "IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology during infection and autoimmunity. IL-17A and IL-17F are produced by CD4+ and CD8+ T cells, γδ T cells, and various innate immune cell populations in response to IL-1β and IL-23, and they mediate protective immunity against fungi and bacteria by promoting neutrophil recruitment, antimicrobial peptide production and enhanced barrier function. IL-17-driven inflammation is normally controlled by regulatory T cells and the anti-inflammatory cytokines IL-10, TGFβ and IL-35. However, if dysregulated, IL-17 responses can promote immunopathology in the context of infection or autoimmunity. Moreover, IL-17 has been implicated in the pathogenesis of many other disorders with an inflammatory basis, including cardiovascular and neurological diseases. Consequently, the IL-17 pathway is now a key drug target in many autoimmune and chronic inflammatory disorders; therapeutic monoclonal antibodies targeting IL-17A, both IL-17A and IL-17F, the IL-17 receptor, or IL-23 are highly effective in some of these diseases. However, new approaches are needed to specifically regulate IL-17-mediated immunopathology in chronic inflammation and autoimmunity without compromising protective immunity to infection." @default.
- W4284693043 created "2022-07-08" @default.
- W4284693043 creator A5005518920 @default.
- W4284693043 date "2022-07-05" @default.
- W4284693043 modified "2023-10-18" @default.
- W4284693043 title "IL-17 and IL-17-producing cells in protection versus pathology" @default.
- W4284693043 cites W1504328662 @default.
- W4284693043 cites W1515424972 @default.
- W4284693043 cites W1520466547 @default.
- W4284693043 cites W1539015570 @default.
- W4284693043 cites W1543653831 @default.
- W4284693043 cites W1546232808 @default.
- W4284693043 cites W1555287564 @default.
- W4284693043 cites W1556079656 @default.
- W4284693043 cites W1558841808 @default.
- W4284693043 cites W1579017906 @default.
- W4284693043 cites W1592394199 @default.
- W4284693043 cites W1614324271 @default.
- W4284693043 cites W1620097935 @default.
- W4284693043 cites W1664996601 @default.
- W4284693043 cites W1668706061 @default.
- W4284693043 cites W1773193600 @default.
- W4284693043 cites W1788119937 @default.
- W4284693043 cites W1834013341 @default.
- W4284693043 cites W1836263069 @default.
- W4284693043 cites W1892542831 @default.
- W4284693043 cites W1911161962 @default.
- W4284693043 cites W1924380388 @default.
- W4284693043 cites W1935392444 @default.
- W4284693043 cites W1935617463 @default.
- W4284693043 cites W1939997832 @default.
- W4284693043 cites W1964052073 @default.
- W4284693043 cites W1967840465 @default.
- W4284693043 cites W1971044473 @default.
- W4284693043 cites W1973354423 @default.
- W4284693043 cites W1981032637 @default.
- W4284693043 cites W1981714996 @default.
- W4284693043 cites W1985408969 @default.
- W4284693043 cites W1986175684 @default.
- W4284693043 cites W1986193304 @default.
- W4284693043 cites W1987628377 @default.
- W4284693043 cites W1993273784 @default.
- W4284693043 cites W1996770717 @default.
- W4284693043 cites W1997570781 @default.
- W4284693043 cites W1998000193 @default.
- W4284693043 cites W1998541797 @default.
- W4284693043 cites W1999561404 @default.
- W4284693043 cites W2000086986 @default.
- W4284693043 cites W2002967050 @default.
- W4284693043 cites W2006249161 @default.
- W4284693043 cites W2007782352 @default.
- W4284693043 cites W2007859732 @default.
- W4284693043 cites W2009675211 @default.
- W4284693043 cites W2009868429 @default.
- W4284693043 cites W2012077729 @default.
- W4284693043 cites W2014112474 @default.
- W4284693043 cites W2014556823 @default.
- W4284693043 cites W2014785961 @default.
- W4284693043 cites W2014913358 @default.
- W4284693043 cites W2014960954 @default.
- W4284693043 cites W2017893786 @default.
- W4284693043 cites W2019970499 @default.
- W4284693043 cites W2020373191 @default.
- W4284693043 cites W2021674244 @default.
- W4284693043 cites W2029393400 @default.
- W4284693043 cites W2034885002 @default.
- W4284693043 cites W2036463856 @default.
- W4284693043 cites W2037980590 @default.
- W4284693043 cites W2039260367 @default.
- W4284693043 cites W2040080235 @default.
- W4284693043 cites W2043198160 @default.
- W4284693043 cites W2043258872 @default.
- W4284693043 cites W2049448291 @default.
- W4284693043 cites W2050244205 @default.
- W4284693043 cites W2051148575 @default.
- W4284693043 cites W2054235049 @default.
- W4284693043 cites W2058443507 @default.
- W4284693043 cites W2060216716 @default.
- W4284693043 cites W2065307318 @default.
- W4284693043 cites W2065958240 @default.
- W4284693043 cites W2067885308 @default.
- W4284693043 cites W2070856968 @default.
- W4284693043 cites W2071499075 @default.
- W4284693043 cites W2074064949 @default.
- W4284693043 cites W2076794463 @default.
- W4284693043 cites W2082848636 @default.
- W4284693043 cites W2084533546 @default.
- W4284693043 cites W2085977010 @default.
- W4284693043 cites W2092252407 @default.
- W4284693043 cites W2092975931 @default.
- W4284693043 cites W2094771034 @default.
- W4284693043 cites W2095753163 @default.
- W4284693043 cites W2095880232 @default.
- W4284693043 cites W2098370101 @default.
- W4284693043 cites W2100990607 @default.
- W4284693043 cites W2101180663 @default.
- W4284693043 cites W2101295380 @default.
- W4284693043 cites W2101365364 @default.