Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284693142> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4284693142 abstract "Abstract Reactive oxygen species (ROS) production is critical for the initiation of wound repair; However, persistent high levels of reactive oxygen species can lead to lipid peroxidation of cells and thus affect wound healing. Iron is a transition metal that is an essential component of almost all living cells and organisms. when present in excess in cells and tissues, iron disrupts redox homeostasis and catalyses the generation of ROS, leading to increased lipid peroxidation. In this study, we found that after treating interepithelial follicular (IFE) cells with different concentrations of transferrin (0 µg/ml, 1 µg/ml, 10 µg/ml, 100 µg/ml, and 1 mg/ml), we increased the intracellular iron content, and our findings regarding viability and function did not differ significantly between groups of cells. It was also found that the level of lipid peroxidation in IFE cells did not increase. We speculate that there is a protective mechanism within IFE cells that reduces the occurrence of intracellular lipid peroxidation. We found that the elevated intracellular iron content of IFE cells was accompanied by elevated ALDH3B1 expression. We investigated the effect of ALDH3B1 on the level of lipid peroxidation in IFE cells and found that the elevated expression of ALDH3B1 could decrease the damage to IFE cells by lipid peroxidation. In addition, the NRF2 pathway was found to affect the expression of ALDH3B1, which in turn affected lipid peroxidation in IFE cells. In conclusion, these findings suggest that in IFE cells, activation of the NRF2 pathway can increase the expression of ALDH3B1 and thus reduce the production of intracellular ROS and the occurrence of intracellular lipid peroxidation. Therefore, ALDH3B1 may be a potential target for the treatment of chronic wounds." @default.
- W4284693142 created "2022-07-08" @default.
- W4284693142 creator A5008387548 @default.
- W4284693142 creator A5028954794 @default.
- W4284693142 creator A5031890019 @default.
- W4284693142 creator A5040394890 @default.
- W4284693142 creator A5040825774 @default.
- W4284693142 creator A5045870173 @default.
- W4284693142 creator A5048933705 @default.
- W4284693142 creator A5052767239 @default.
- W4284693142 creator A5052955470 @default.
- W4284693142 creator A5059827612 @default.
- W4284693142 creator A5060165452 @default.
- W4284693142 date "2022-07-05" @default.
- W4284693142 modified "2023-10-16" @default.
- W4284693142 title "ALDH3B1 protects interfollicular epidermal cells against lipid peroxidation via the NRF2 pathway" @default.
- W4284693142 doi "https://doi.org/10.21203/rs.3.rs-1795852/v1" @default.
- W4284693142 hasPublicationYear "2022" @default.
- W4284693142 type Work @default.
- W4284693142 citedByCount "1" @default.
- W4284693142 countsByYear W42846931422022 @default.
- W4284693142 crossrefType "posted-content" @default.
- W4284693142 hasAuthorship W4284693142A5008387548 @default.
- W4284693142 hasAuthorship W4284693142A5028954794 @default.
- W4284693142 hasAuthorship W4284693142A5031890019 @default.
- W4284693142 hasAuthorship W4284693142A5040394890 @default.
- W4284693142 hasAuthorship W4284693142A5040825774 @default.
- W4284693142 hasAuthorship W4284693142A5045870173 @default.
- W4284693142 hasAuthorship W4284693142A5048933705 @default.
- W4284693142 hasAuthorship W4284693142A5052767239 @default.
- W4284693142 hasAuthorship W4284693142A5052955470 @default.
- W4284693142 hasAuthorship W4284693142A5059827612 @default.
- W4284693142 hasAuthorship W4284693142A5060165452 @default.
- W4284693142 hasBestOaLocation W42846931421 @default.
- W4284693142 hasConcept C185592680 @default.
- W4284693142 hasConcept C2776151105 @default.
- W4284693142 hasConcept C2779308327 @default.
- W4284693142 hasConcept C2780829032 @default.
- W4284693142 hasConcept C48349386 @default.
- W4284693142 hasConcept C55493867 @default.
- W4284693142 hasConcept C79879829 @default.
- W4284693142 hasConcept C86803240 @default.
- W4284693142 hasConcept C95444343 @default.
- W4284693142 hasConceptScore W4284693142C185592680 @default.
- W4284693142 hasConceptScore W4284693142C2776151105 @default.
- W4284693142 hasConceptScore W4284693142C2779308327 @default.
- W4284693142 hasConceptScore W4284693142C2780829032 @default.
- W4284693142 hasConceptScore W4284693142C48349386 @default.
- W4284693142 hasConceptScore W4284693142C55493867 @default.
- W4284693142 hasConceptScore W4284693142C79879829 @default.
- W4284693142 hasConceptScore W4284693142C86803240 @default.
- W4284693142 hasConceptScore W4284693142C95444343 @default.
- W4284693142 hasLocation W42846931421 @default.
- W4284693142 hasOpenAccess W4284693142 @default.
- W4284693142 hasPrimaryLocation W42846931421 @default.
- W4284693142 hasRelatedWork W1507112934 @default.
- W4284693142 hasRelatedWork W1542447625 @default.
- W4284693142 hasRelatedWork W1966211672 @default.
- W4284693142 hasRelatedWork W1992782534 @default.
- W4284693142 hasRelatedWork W2025909901 @default.
- W4284693142 hasRelatedWork W2104368545 @default.
- W4284693142 hasRelatedWork W2111649022 @default.
- W4284693142 hasRelatedWork W3027349942 @default.
- W4284693142 hasRelatedWork W3048656316 @default.
- W4284693142 hasRelatedWork W4285310363 @default.
- W4284693142 isParatext "false" @default.
- W4284693142 isRetracted "false" @default.
- W4284693142 workType "article" @default.