FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284693908> ?p ?o ?g. }

• W4284693908 abstract "ABSTRACT The metabolism of all living organisms is dependent on temperature, and therefore, having a good method to predict temperature effects at a system level is of importance. A recently developed Bayesian computational framework for enzyme and temperature constrained genome-scale models (etcGEM) predicts the temperature dependence of an organism’s metabolic network from thermodynamic properties of the metabolic enzymes, markedly expanding the scope and applicability of constraint-based metabolic modelling. Here, we show that the Bayesian calculation method for inferring parameters for an etcGEM is unstable and unable to estimate the posterior distribution. The Bayesian calculation method assumes that the posterior distribution is unimodal, and thus fails due to the multimodality of the problem. To remedy this problem, we developed an evolutionary algorithm which is able to obtain a diversity of solutions in this multimodal parameter space. We quantified the phenotypic consequences on six metabolic network signature reactions of the different parameter solutions resulting from use of the evolutionary algorithm. While two of these reactions showed little phenotypic variation between the solutions, the remainder displayed huge variation in flux-carrying capacity. This result indicates that the model is underdetermined given current experimental data and that more data is required to narrow down the model predictions. Finally, we made improvements to the software to reduce the running time of the parameter set evaluations by a factor of 8.5, allowing for obtaining results faster and with less computational resources." @default.
• W4284693908 created "2022-07-08" @default.
• W4284693908 creator A5003678652 @default.
• W4284693908 creator A5071622493 @default.
• W4284693908 date "2022-07-05" @default.
• W4284693908 modified "2023-10-17" @default.
• W4284693908 title "Parameter inference for enzyme and temperature constrained genome-scale models" @default.
• W4284693908 cites W1595591865 @default.
• W4284693908 cites W1965092590 @default.
• W4284693908 cites W1970276173 @default.
• W4284693908 cites W1981075842 @default.
• W4284693908 cites W1985059772 @default.
• W4284693908 cites W2017258920 @default.
• W4284693908 cites W2026089579 @default.
• W4284693908 cites W2048465561 @default.
• W4284693908 cites W2059125944 @default.
• W4284693908 cites W2067469807 @default.
• W4284693908 cites W2076262841 @default.
• W4284693908 cites W2100818174 @default.
• W4284693908 cites W2102164505 @default.
• W4284693908 cites W2128747143 @default.
• W4284693908 cites W2146879413 @default.
• W4284693908 cites W2162719167 @default.
• W4284693908 cites W2294798173 @default.
• W4284693908 cites W2419380513 @default.
• W4284693908 cites W2509358643 @default.
• W4284693908 cites W2599070308 @default.
• W4284693908 cites W2734978797 @default.
• W4284693908 cites W2737361097 @default.
• W4284693908 cites W2743063996 @default.
• W4284693908 cites W2794599858 @default.
• W4284693908 cites W3003224093 @default.
• W4284693908 cites W3082397379 @default.
• W4284693908 cites W3094704314 @default.
• W4284693908 cites W3121123436 @default.
• W4284693908 cites W4200028525 @default.
• W4284693908 cites W4206703469 @default.
• W4284693908 cites W4212976070 @default.
• W4284693908 cites W4248917005 @default.
• W4284693908 cites W657240017 @default.
• W4284693908 doi "https://doi.org/10.1101/2022.07.05.498798" @default.
• W4284693908 hasPublicationYear "2022" @default.
• W4284693908 type Work @default.
• W4284693908 citedByCount "0" @default.
• W4284693908 crossrefType "posted-content" @default.
• W4284693908 hasAuthorship W4284693908A5003678652 @default.
• W4284693908 hasAuthorship W4284693908A5071622493 @default.
• W4284693908 hasBestOaLocation W42846939081 @default.
• W4284693908 hasConcept C107673813 @default.
• W4284693908 hasConcept C11413529 @default.
• W4284693908 hasConcept C121332964 @default.
• W4284693908 hasConcept C126255220 @default.
• W4284693908 hasConcept C154945302 @default.
• W4284693908 hasConcept C160234255 @default.
• W4284693908 hasConcept C162376815 @default.
• W4284693908 hasConcept C177264268 @default.
• W4284693908 hasConcept C179690561 @default.
• W4284693908 hasConcept C199360897 @default.
• W4284693908 hasConcept C2524010 @default.
• W4284693908 hasConcept C2776036281 @default.
• W4284693908 hasConcept C2776214188 @default.
• W4284693908 hasConcept C2778755073 @default.
• W4284693908 hasConcept C2779377595 @default.
• W4284693908 hasConcept C33923547 @default.
• W4284693908 hasConcept C41008148 @default.
• W4284693908 hasConcept C45374587 @default.
• W4284693908 hasConcept C62520636 @default.
• W4284693908 hasConceptScore W4284693908C107673813 @default.
• W4284693908 hasConceptScore W4284693908C11413529 @default.
• W4284693908 hasConceptScore W4284693908C121332964 @default.
• W4284693908 hasConceptScore W4284693908C126255220 @default.
• W4284693908 hasConceptScore W4284693908C154945302 @default.
• W4284693908 hasConceptScore W4284693908C160234255 @default.
• W4284693908 hasConceptScore W4284693908C162376815 @default.
• W4284693908 hasConceptScore W4284693908C177264268 @default.
• W4284693908 hasConceptScore W4284693908C179690561 @default.
• W4284693908 hasConceptScore W4284693908C199360897 @default.
• W4284693908 hasConceptScore W4284693908C2524010 @default.
• W4284693908 hasConceptScore W4284693908C2776036281 @default.
• W4284693908 hasConceptScore W4284693908C2776214188 @default.
• W4284693908 hasConceptScore W4284693908C2778755073 @default.
• W4284693908 hasConceptScore W4284693908C2779377595 @default.
• W4284693908 hasConceptScore W4284693908C33923547 @default.
• W4284693908 hasConceptScore W4284693908C41008148 @default.
• W4284693908 hasConceptScore W4284693908C45374587 @default.
• W4284693908 hasConceptScore W4284693908C62520636 @default.
• W4284693908 hasLocation W42846939081 @default.
• W4284693908 hasOpenAccess W4284693908 @default.
• W4284693908 hasPrimaryLocation W42846939081 @default.
• W4284693908 hasRelatedWork W2078526825 @default.
• W4284693908 hasRelatedWork W2290754432 @default.
• W4284693908 hasRelatedWork W2901441036 @default.
• W4284693908 hasRelatedWork W3124023584 @default.
• W4284693908 hasRelatedWork W3124497799 @default.
• W4284693908 hasRelatedWork W3131352612 @default.
• W4284693908 hasRelatedWork W3145488977 @default.
• W4284693908 hasRelatedWork W4231471330 @default.
• W4284693908 hasRelatedWork W4297011314 @default.
• W4284693908 hasRelatedWork W4307312013 @default.
• W4284693908 isParatext "false" @default.

• next