Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284698892> ?p ?o ?g. }
- W4284698892 endingPage "3287" @default.
- W4284698892 startingPage "3287" @default.
- W4284698892 abstract "Breast cancer stem cells (BCSCs) constitute a small population of cells within breast cancer and are characterized by their ability to self-renew, differentiate, and recapitulate the heterogeneity of the tumor. Clinically, BCSCs have been correlated with cancer progression, metastasis, relapse, and drug resistance. The tumorigenic roles of BCSCs have been extensively reviewed and will not be the major focus of the current review. Here, we aim to highlight how the crucial intrinsic signaling pathways regulate the fate of BCSCs, including the Wnt, Notch, Hedgehog, and NF-κB signaling pathways, as well as how different cell populations crosstalk with BCSCs within the TME, including adipocytes, endothelial cells, fibroblasts, and immune cells. Based on the molecular and cellular activities of BCSCs, we will also summarize the targeting strategies for BCSCs and related clinical trials. This review will highlight that BCSC development in breast cancer is impacted by both BCSC endogenous signaling and external factors in the TME, which provides an insight into how to establish a comprehensively therapeutic strategy to target BCSCs for breast cancer treatments." @default.
- W4284698892 created "2022-07-08" @default.
- W4284698892 creator A5005379578 @default.
- W4284698892 creator A5031160768 @default.
- W4284698892 creator A5039000243 @default.
- W4284698892 creator A5041054598 @default.
- W4284698892 creator A5056247439 @default.
- W4284698892 creator A5066527083 @default.
- W4284698892 creator A5068729390 @default.
- W4284698892 creator A5082394615 @default.
- W4284698892 creator A5087786112 @default.
- W4284698892 date "2022-07-05" @default.
- W4284698892 modified "2023-10-10" @default.
- W4284698892 title "Breast Cancer Stem Cells: Signaling Pathways, Cellular Interactions, and Therapeutic Implications" @default.
- W4284698892 cites W1735670763 @default.
- W4284698892 cites W1781050812 @default.
- W4284698892 cites W1835001457 @default.
- W4284698892 cites W1853160207 @default.
- W4284698892 cites W1940439262 @default.
- W4284698892 cites W1959965398 @default.
- W4284698892 cites W1964081206 @default.
- W4284698892 cites W1966227037 @default.
- W4284698892 cites W1969600175 @default.
- W4284698892 cites W1970915933 @default.
- W4284698892 cites W1971047979 @default.
- W4284698892 cites W1971949613 @default.
- W4284698892 cites W1972642182 @default.
- W4284698892 cites W1972694890 @default.
- W4284698892 cites W1973259074 @default.
- W4284698892 cites W1973569665 @default.
- W4284698892 cites W1974008072 @default.
- W4284698892 cites W1974140746 @default.
- W4284698892 cites W1974599416 @default.
- W4284698892 cites W1975378253 @default.
- W4284698892 cites W1976124684 @default.
- W4284698892 cites W1980825754 @default.
- W4284698892 cites W1984413324 @default.
- W4284698892 cites W1984484474 @default.
- W4284698892 cites W1989805762 @default.
- W4284698892 cites W1990738741 @default.
- W4284698892 cites W1991128404 @default.
- W4284698892 cites W1991734968 @default.
- W4284698892 cites W1991953785 @default.
- W4284698892 cites W2001710411 @default.
- W4284698892 cites W2001933408 @default.
- W4284698892 cites W2005972147 @default.
- W4284698892 cites W2007518082 @default.
- W4284698892 cites W2009906157 @default.
- W4284698892 cites W2010601523 @default.
- W4284698892 cites W2012015174 @default.
- W4284698892 cites W2014691022 @default.
- W4284698892 cites W2017180102 @default.
- W4284698892 cites W2018047723 @default.
- W4284698892 cites W2018372624 @default.
- W4284698892 cites W2020298913 @default.
- W4284698892 cites W2021822080 @default.
- W4284698892 cites W2023316892 @default.
- W4284698892 cites W2023427658 @default.
- W4284698892 cites W2023753181 @default.
- W4284698892 cites W2026691651 @default.
- W4284698892 cites W2032012444 @default.
- W4284698892 cites W2040430549 @default.
- W4284698892 cites W2044702943 @default.
- W4284698892 cites W2044905529 @default.
- W4284698892 cites W2045066549 @default.
- W4284698892 cites W2045356922 @default.
- W4284698892 cites W2046319746 @default.
- W4284698892 cites W2047566408 @default.
- W4284698892 cites W2052515705 @default.
- W4284698892 cites W2053976478 @default.
- W4284698892 cites W2054454072 @default.
- W4284698892 cites W2063373713 @default.
- W4284698892 cites W2066368614 @default.
- W4284698892 cites W2066446030 @default.
- W4284698892 cites W2069526613 @default.
- W4284698892 cites W2070632651 @default.
- W4284698892 cites W2071852394 @default.
- W4284698892 cites W2079471715 @default.
- W4284698892 cites W2079777624 @default.
- W4284698892 cites W2080457126 @default.
- W4284698892 cites W2081925297 @default.
- W4284698892 cites W2083087817 @default.
- W4284698892 cites W2084888861 @default.
- W4284698892 cites W2085872402 @default.
- W4284698892 cites W2087470472 @default.
- W4284698892 cites W2090229207 @default.
- W4284698892 cites W2093091016 @default.
- W4284698892 cites W2095320189 @default.
- W4284698892 cites W2096283457 @default.
- W4284698892 cites W2096768863 @default.
- W4284698892 cites W2097733789 @default.
- W4284698892 cites W2101315990 @default.
- W4284698892 cites W2101380428 @default.
- W4284698892 cites W2103288147 @default.
- W4284698892 cites W2103709809 @default.
- W4284698892 cites W2110327197 @default.
- W4284698892 cites W2110881853 @default.
- W4284698892 cites W2113904360 @default.