Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284701119> ?p ?o ?g. }
- W4284701119 endingPage "e1010645" @default.
- W4284701119 startingPage "e1010645" @default.
- W4284701119 abstract "Avian influenza virus (AIV) can evolve multiple strategies to combat host antiviral defenses and establish efficient infectivity in mammals, including humans. H9N2 AIV and its reassortants (such as H5N6 and H7N9 viruses) pose an increasing threat to human health; however, the mechanisms involved in their increased virulence remain poorly understood. We previously reported that the M1 mutation T37A has become predominant among chicken H9N2 isolates in China. Here, we report that, since 2010, this mutation has also been found in the majority of human isolates of H9N2 AIV and its emerging reassortants. The T37A mutation of M1 protein enhances the replication of H9N2 AIVs in mice and in human cells. Interestingly, having A37 instead of T37 increases the M1 protein stability and resistance to proteasomal degradation. Moreover, T37 of the H9N2 M1 protein is phosphorylated by protein kinase G (PKG), and this phosphorylation induces the rapid degradation of M1 and reduces viral replication. Similar effects are also observed in the novel H5N6 virus. Additionally, ubiquitination at K187 contributes to M1-37T degradation and decreased replication of the virus harboring T37 in the M1 protein. The prevailing AIVs thereby evolve a phospho-resistant mutation in the M1 protein to avoid viral protein degradation by host factors, which is advantageous in terms of replication in mammalian hosts." @default.
- W4284701119 created "2022-07-08" @default.
- W4284701119 creator A5011263744 @default.
- W4284701119 creator A5012807529 @default.
- W4284701119 creator A5029675898 @default.
- W4284701119 creator A5034032847 @default.
- W4284701119 creator A5052704857 @default.
- W4284701119 creator A5055958896 @default.
- W4284701119 creator A5059575071 @default.
- W4284701119 creator A5060936249 @default.
- W4284701119 creator A5061582217 @default.
- W4284701119 creator A5063635764 @default.
- W4284701119 creator A5065037360 @default.
- W4284701119 creator A5075282134 @default.
- W4284701119 date "2022-07-06" @default.
- W4284701119 modified "2023-10-16" @default.
- W4284701119 title "Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals" @default.
- W4284701119 cites W150998259 @default.
- W4284701119 cites W1603867145 @default.
- W4284701119 cites W1868415946 @default.
- W4284701119 cites W1965805827 @default.
- W4284701119 cites W1966248343 @default.
- W4284701119 cites W1972378799 @default.
- W4284701119 cites W1972427014 @default.
- W4284701119 cites W1975333364 @default.
- W4284701119 cites W1979192195 @default.
- W4284701119 cites W1983436595 @default.
- W4284701119 cites W1989231026 @default.
- W4284701119 cites W1997835441 @default.
- W4284701119 cites W2004313038 @default.
- W4284701119 cites W2031317676 @default.
- W4284701119 cites W2036081096 @default.
- W4284701119 cites W2040185402 @default.
- W4284701119 cites W2042549207 @default.
- W4284701119 cites W2045934762 @default.
- W4284701119 cites W2049232681 @default.
- W4284701119 cites W2050600731 @default.
- W4284701119 cites W2052334391 @default.
- W4284701119 cites W2057623594 @default.
- W4284701119 cites W2059303389 @default.
- W4284701119 cites W2063842030 @default.
- W4284701119 cites W2066893024 @default.
- W4284701119 cites W2072610221 @default.
- W4284701119 cites W2082030984 @default.
- W4284701119 cites W2094932456 @default.
- W4284701119 cites W2102891343 @default.
- W4284701119 cites W2103693415 @default.
- W4284701119 cites W2106173155 @default.
- W4284701119 cites W2110233172 @default.
- W4284701119 cites W2112982331 @default.
- W4284701119 cites W2114492491 @default.
- W4284701119 cites W2125739732 @default.
- W4284701119 cites W2131411612 @default.
- W4284701119 cites W2134194388 @default.
- W4284701119 cites W2147921405 @default.
- W4284701119 cites W2150091336 @default.
- W4284701119 cites W2171895134 @default.
- W4284701119 cites W2207811638 @default.
- W4284701119 cites W2474833598 @default.
- W4284701119 cites W2530977520 @default.
- W4284701119 cites W2557499142 @default.
- W4284701119 cites W2584757905 @default.
- W4284701119 cites W2788812105 @default.
- W4284701119 cites W2905439670 @default.
- W4284701119 cites W2915952373 @default.
- W4284701119 cites W2939562144 @default.
- W4284701119 cites W2952818759 @default.
- W4284701119 cites W2969491380 @default.
- W4284701119 cites W2974870070 @default.
- W4284701119 cites W3018875868 @default.
- W4284701119 doi "https://doi.org/10.1371/journal.ppat.1010645" @default.
- W4284701119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35793327" @default.
- W4284701119 hasPublicationYear "2022" @default.
- W4284701119 type Work @default.
- W4284701119 citedByCount "3" @default.
- W4284701119 countsByYear W42847011192023 @default.
- W4284701119 crossrefType "journal-article" @default.
- W4284701119 hasAuthorship W4284701119A5011263744 @default.
- W4284701119 hasAuthorship W4284701119A5012807529 @default.
- W4284701119 hasAuthorship W4284701119A5029675898 @default.
- W4284701119 hasAuthorship W4284701119A5034032847 @default.
- W4284701119 hasAuthorship W4284701119A5052704857 @default.
- W4284701119 hasAuthorship W4284701119A5055958896 @default.
- W4284701119 hasAuthorship W4284701119A5059575071 @default.
- W4284701119 hasAuthorship W4284701119A5060936249 @default.
- W4284701119 hasAuthorship W4284701119A5061582217 @default.
- W4284701119 hasAuthorship W4284701119A5063635764 @default.
- W4284701119 hasAuthorship W4284701119A5065037360 @default.
- W4284701119 hasAuthorship W4284701119A5075282134 @default.
- W4284701119 hasBestOaLocation W42847011191 @default.
- W4284701119 hasConcept C104317684 @default.
- W4284701119 hasConcept C106358424 @default.
- W4284701119 hasConcept C11960822 @default.
- W4284701119 hasConcept C140704245 @default.
- W4284701119 hasConcept C159047783 @default.
- W4284701119 hasConcept C2522874641 @default.
- W4284701119 hasConcept C25602115 @default.
- W4284701119 hasConcept C2777546802 @default.