Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284703089> ?p ?o ?g. }
- W4284703089 endingPage "2115" @default.
- W4284703089 startingPage "2115" @default.
- W4284703089 abstract "Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix (ECM) protein belonging to the fibrinogen-related domain superfamily. MFAP4 is highly expressed in elastin-rich tissues such as lung, blood vessels and skin. MFAP4 is involved in organization of the ECM, regulating proper elastic fiber assembly. On the other hand, during pathology MFAP4 actively contributes to disease development and progression due to its interactions with RGD-dependent integrin receptors. Both tissue expression and circulating MFAP4 levels are associated with various disorders, including liver fibrosis and cancer. In other experimental models, such as teleost fish, MFAP4 appears to participate in host defense as a macrophage-specific innate immune molecule. The aim of this review is to summarize the accumulating evidence that indicates the importance of MFAP4 in homeostasis as well as pathological conditions, discuss its known biological functions with special focus on elastic fiber assembly, integrin signaling and cancer, as well as describe the reported functions of non-mammalian MFAP4 in fish. Overall, our work provides a comprehensive overview on the role of MFAP4 in health and disease." @default.
- W4284703089 created "2022-07-08" @default.
- W4284703089 creator A5044390360 @default.
- W4284703089 creator A5060771905 @default.
- W4284703089 creator A5062489199 @default.
- W4284703089 date "2022-07-05" @default.
- W4284703089 modified "2023-09-26" @default.
- W4284703089 title "MFAP4-Mediated Effects in Elastic Fiber Homeostasis, Integrin Signaling and Cancer, and Its Role in Teleost Fish" @default.
- W4284703089 cites W1493198798 @default.
- W4284703089 cites W1537961455 @default.
- W4284703089 cites W1597339764 @default.
- W4284703089 cites W1768532341 @default.
- W4284703089 cites W1910850152 @default.
- W4284703089 cites W1965508013 @default.
- W4284703089 cites W1967537173 @default.
- W4284703089 cites W1969749903 @default.
- W4284703089 cites W1970559524 @default.
- W4284703089 cites W1971067720 @default.
- W4284703089 cites W1973027060 @default.
- W4284703089 cites W1973457542 @default.
- W4284703089 cites W197462632 @default.
- W4284703089 cites W1975524531 @default.
- W4284703089 cites W1980353886 @default.
- W4284703089 cites W1980545405 @default.
- W4284703089 cites W1981454034 @default.
- W4284703089 cites W1986553481 @default.
- W4284703089 cites W1993230767 @default.
- W4284703089 cites W1994785305 @default.
- W4284703089 cites W1994996757 @default.
- W4284703089 cites W1995080789 @default.
- W4284703089 cites W2002709652 @default.
- W4284703089 cites W2004091608 @default.
- W4284703089 cites W2014896262 @default.
- W4284703089 cites W2017921050 @default.
- W4284703089 cites W2030017298 @default.
- W4284703089 cites W2039914635 @default.
- W4284703089 cites W2042571711 @default.
- W4284703089 cites W2056200375 @default.
- W4284703089 cites W2058345218 @default.
- W4284703089 cites W2059695507 @default.
- W4284703089 cites W2059933339 @default.
- W4284703089 cites W2065619723 @default.
- W4284703089 cites W2074774606 @default.
- W4284703089 cites W2078208642 @default.
- W4284703089 cites W2079278133 @default.
- W4284703089 cites W2081177433 @default.
- W4284703089 cites W2082280203 @default.
- W4284703089 cites W2084080290 @default.
- W4284703089 cites W2084397808 @default.
- W4284703089 cites W2084403389 @default.
- W4284703089 cites W2086828658 @default.
- W4284703089 cites W2090189165 @default.
- W4284703089 cites W2091340588 @default.
- W4284703089 cites W2092152806 @default.
- W4284703089 cites W2092855637 @default.
- W4284703089 cites W2094148152 @default.
- W4284703089 cites W2097081828 @default.
- W4284703089 cites W2100660634 @default.
- W4284703089 cites W2105892139 @default.
- W4284703089 cites W2106365753 @default.
- W4284703089 cites W2108713158 @default.
- W4284703089 cites W2111563692 @default.
- W4284703089 cites W2113937608 @default.
- W4284703089 cites W2116514710 @default.
- W4284703089 cites W2116686272 @default.
- W4284703089 cites W2117189371 @default.
- W4284703089 cites W2117211947 @default.
- W4284703089 cites W2126612251 @default.
- W4284703089 cites W2133183716 @default.
- W4284703089 cites W2133904925 @default.
- W4284703089 cites W2136587558 @default.
- W4284703089 cites W2137987395 @default.
- W4284703089 cites W2143807536 @default.
- W4284703089 cites W2144356448 @default.
- W4284703089 cites W2145335014 @default.
- W4284703089 cites W2155233047 @default.
- W4284703089 cites W2163078748 @default.
- W4284703089 cites W2177003396 @default.
- W4284703089 cites W2181242709 @default.
- W4284703089 cites W2215102004 @default.
- W4284703089 cites W2285622164 @default.
- W4284703089 cites W2395401764 @default.
- W4284703089 cites W2465066967 @default.
- W4284703089 cites W2476542314 @default.
- W4284703089 cites W2627053690 @default.
- W4284703089 cites W272428685 @default.
- W4284703089 cites W2749613778 @default.
- W4284703089 cites W2790455901 @default.
- W4284703089 cites W2807484119 @default.
- W4284703089 cites W2887670374 @default.
- W4284703089 cites W2892549650 @default.
- W4284703089 cites W2910977678 @default.
- W4284703089 cites W2919212025 @default.
- W4284703089 cites W2920879064 @default.
- W4284703089 cites W2955621747 @default.
- W4284703089 cites W2962763288 @default.
- W4284703089 cites W2962865476 @default.
- W4284703089 cites W2965908876 @default.