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• W4284703485 abstract "Abstract Background: About 85% of patients receiving opioid agonist therapy (OAT) for opioid dependence are smoking tobacco. Although smoke-related pulmonary diseases are significant contributors to morbidity and mortality, few smoking cessation interventions are evaluated within this group, and few OAT patients are offered smoking cessation as an integrated part of their addiction treatment. This study protocol describes an integrated smoking cessation intervention aimed at patients receiving OAT and smoking tobacco. Methods: This is a multicentre, randomised controlled clinical trial that will recruit 266 daily tobacco smoking patients receiving OAT in OAT outpatient clinics in Bergen and Stavanger, Norway. The patients randomised for the intervention arm will be offered smoking cessation therapy consisting of weekly brief behavioural interventions and prescription-free nicotine replacement products. In the control arm, patients will receive standard care without any added interventions related to smoking cessation.The smoking cessation intervention includes psychoeducational techniques with components from motivational interviewing, and nicotine replacement products such as nicotine lozenges, patches and chewing gum. The duration of the intervention is 16 weeks, with the option of extending it with a further eight weeks. The main outcomes are measured at 16 weeks after initiation of the intervention, and sustained effects are evaluated one year after intervention initiation. The primary outcome is smoking cessation verified by carbon monoxide (CO)-levels or at least a 50% reduction in the number of cigarettes smoked. Secondary outcomes are changes in psychological well-being, biochemical inflammation markers, changes in physical health functioning, quality of life and fatigue. Discussion: Integration of other treatments to standard OAT care improves adherence and completion rates providing another rationale for integrated smoking cessation treatment. Thus, if integrated smoking cessation treatment is superior to standard care, this trial provides important information on further scale-up. Trial registration: ClinicalTrials.gov NCT05290025, Date of registry 22. March 2022" @default.
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• W4284703485 date "2022-07-07" @default.
• W4284703485 modified "2023-09-29" @default.
• W4284703485 title "Integration of Smoking Cessation Into Standard Treatment for Patients Receiving Opioid Agonist Therapy Who Are Smoking Tobacco: Protocol for a Randomised Controlled Trial (ATLAS4LAR)" @default.
• W4284703485 doi "https://doi.org/10.21203/rs.3.rs-1616715/v1" @default.
• W4284703485 hasPublicationYear "2022" @default.
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