FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284706232> ?p ?o ?g. }

• W4284706232 endingPage "279" @default.
• W4284706232 startingPage "274" @default.
• W4284706232 abstract "Purpose of review Multisystem inflammatory syndrome in children (MIS-C) is a postinfectious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection primarily affecting children. MIS-C shares features with Kawasaki disease (KD) and cytokine storm syndrome (CSS) frequently requiring intensive care support. Although intravenous immunoglobulin (IVIg) and glucocorticoids (GCs) are effective therapeutics for most, refractory MIS-C is treated with various biologic disease-modifying antirheumatic drugs (bDMARDs). Understanding the clinical features, inflammatory cytokines, and genetic associations provides rationale for bDMARD in treating severe MIS-C. Recent findings Children with MIS-C have clinical KD features and often present in hypovolemic and cardiogenic shock requiring volume repletion (gastrointestinaI losses) and cardiac pressor support (epinephrine). Investigation of MIS-C serum reveals elevated pro-inflammatory cytokines [interleukin (IL)-1, IL-6, IL-18, interferon gamma (IFNγ), tumor necrosis factor (TNF)], but to a lesser extent than other established CSS. Gene sequencing of MIS-C children identifies heterozygous mutations in CSS associated genes. Treatment of refractory (IVIg and GC) MIS-C with bDMARDs to IL-1, IL-6, and TNF is efficacious for survival as well as resolving cardiac and coronary artery inflammation. Summary MIS-C is a postinfectious complication of SARS-CoV-2 resembling KD and CSS, both genetically and by pro-inflammatory cytokines. MIS-C that is refractory to IVIg and GC is routinely responsive to bDMARDs targeting IL-1, IL-6, and TNF." @default.
• W4284706232 created "2022-07-08" @default.
• W4284706232 creator A5018471006 @default.
• W4284706232 date "2022-07-05" @default.
• W4284706232 modified "2023-09-27" @default.
• W4284706232 title "Biologic disease-modifying antirheumatic drugs to treat multisystem inflammatory syndrome in children" @default.
• W4284706232 cites W1913742176 @default.
• W4284706232 cites W1967093865 @default.
• W4284706232 cites W2044972453 @default.
• W4284706232 cites W2111495112 @default.
• W4284706232 cites W2114259834 @default.
• W4284706232 cites W2155477306 @default.
• W4284706232 cites W2164721732 @default.
• W4284706232 cites W2177407033 @default.
• W4284706232 cites W2273582653 @default.
• W4284706232 cites W2273799513 @default.
• W4284706232 cites W2552085489 @default.
• W4284706232 cites W2792941879 @default.
• W4284706232 cites W2796022095 @default.
• W4284706232 cites W2797160725 @default.
• W4284706232 cites W2912679257 @default.
• W4284706232 cites W2971225021 @default.
• W4284706232 cites W2973124663 @default.
• W4284706232 cites W2987433176 @default.
• W4284706232 cites W3010819577 @default.
• W4284706232 cites W3012786175 @default.
• W4284706232 cites W3015523006 @default.
• W4284706232 cites W3015607499 @default.
• W4284706232 cites W3021363743 @default.
• W4284706232 cites W3021560285 @default.
• W4284706232 cites W3024521558 @default.
• W4284706232 cites W3034016318 @default.
• W4284706232 cites W3034537415 @default.
• W4284706232 cites W3035696387 @default.
• W4284706232 cites W3036387328 @default.
• W4284706232 cites W3037731101 @default.
• W4284706232 cites W3038003713 @default.
• W4284706232 cites W3043906604 @default.
• W4284706232 cites W3046404304 @default.
• W4284706232 cites W3057416495 @default.
• W4284706232 cites W3080556470 @default.
• W4284706232 cites W3081567385 @default.
• W4284706232 cites W3083598351 @default.
• W4284706232 cites W3084924559 @default.
• W4284706232 cites W3089911709 @default.
• W4284706232 cites W3090250198 @default.
• W4284706232 cites W3112902030 @default.
• W4284706232 cites W3113572510 @default.
• W4284706232 cites W3118337072 @default.
• W4284706232 cites W3121988066 @default.
• W4284706232 cites W3130723351 @default.
• W4284706232 cites W3166141498 @default.
• W4284706232 cites W3173861184 @default.
• W4284706232 cites W3181530483 @default.
• W4284706232 cites W3209064864 @default.
• W4284706232 cites W3216117919 @default.
• W4284706232 cites W4200001853 @default.
• W4284706232 cites W4200401321 @default.
• W4284706232 cites W4211245640 @default.
• W4284706232 cites W4213181816 @default.
• W4284706232 cites W4213416509 @default.
• W4284706232 cites W4214709934 @default.
• W4284706232 cites W4220687594 @default.
• W4284706232 cites W4224861493 @default.
• W4284706232 cites W4226187086 @default.
• W4284706232 cites W4281743020 @default.
• W4284706232 doi "https://doi.org/10.1097/bor.0000000000000889" @default.
• W4284706232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35791863" @default.
• W4284706232 hasPublicationYear "2022" @default.
• W4284706232 type Work @default.
• W4284706232 citedByCount "2" @default.
• W4284706232 countsByYear W42847062322023 @default.
• W4284706232 crossrefType "journal-article" @default.
• W4284706232 hasAuthorship W4284706232A5018471006 @default.
• W4284706232 hasConcept C121332964 @default.
• W4284706232 hasConcept C126322002 @default.
• W4284706232 hasConcept C142424586 @default.
• W4284706232 hasConcept C17991360 @default.
• W4284706232 hasConcept C203014093 @default.
• W4284706232 hasConcept C2776820930 @default.
• W4284706232 hasConcept C2779134260 @default.
• W4284706232 hasConcept C2779559532 @default.
• W4284706232 hasConcept C2779613421 @default.
• W4284706232 hasConcept C2781228260 @default.
• W4284706232 hasConcept C2781423770 @default.
• W4284706232 hasConcept C3008058167 @default.
• W4284706232 hasConcept C524204448 @default.
• W4284706232 hasConcept C71924100 @default.
• W4284706232 hasConcept C87355193 @default.
• W4284706232 hasConceptScore W4284706232C121332964 @default.
• W4284706232 hasConceptScore W4284706232C126322002 @default.
• W4284706232 hasConceptScore W4284706232C142424586 @default.
• W4284706232 hasConceptScore W4284706232C17991360 @default.
• W4284706232 hasConceptScore W4284706232C203014093 @default.
• W4284706232 hasConceptScore W4284706232C2776820930 @default.
• W4284706232 hasConceptScore W4284706232C2779134260 @default.
• W4284706232 hasConceptScore W4284706232C2779559532 @default.
• W4284706232 hasConceptScore W4284706232C2779613421 @default.

• next