Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284712422> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4284712422 endingPage "E640" @default.
- W4284712422 startingPage "E629" @default.
- W4284712422 abstract "Thalamic pain (TP), also known as central post-stroke pain, is a chronic neuropathic pain syndrome that follows a stroke and is a severe pain that is usually intractable. No universally applicable and effective therapies have been proposed. Emerging studies have reported that electroacupuncture (EA) can potentially be used as an effective therapy for the treatment of neuropathic pain. However, whether EA influences TP and if so, by what potential mechanism, remains poorly understood.The aim of this study was to detect the efficacy of EA and explore possible mechanisms for treating TP.Controlled animal study.The laboratory at the Aviation General Hospital of China Medical University and Beijing Institute of Translational Medicine.Male Sprague Dawley rats were randomly divided into 3 groups (n = 15 / group): sham-operated (SH) group, thalamic pain model (TP) group, EA treatment (EA) group. After the TP rat model was successfully established, EA was used for intervention. During the experiment, the mechanical pain thresholds of rats were detected among the groups. The right thalamus of the rats was extracted on postoperative day 28 for RNA-sequencing (RNA-Seq) analysis to find the changes in gene expression in different groups of rats. The key genes were screened using reverse transcription-polymerase chain reaction (RT-PCR) detection and subsequently identified with western blotting and immunofluorescence.The mechanical withdrawal threshold (MWT) value of the right facial skin in the TP group and the EA group decreased significantly on the 3rd day after surgery, compared to the SH group (P < 0.01). From 7 to 28 days, the MWT value increased continually in the EA group; however, there was no significant change in the TP group. The results of RNA-seq showed that compared to the TP group, 377 genes changed in the EA group. Moreover, ADCY1 expression increased significantly in the TP group as compared to the SH group, while EA treatment reversed the expression of ADCY1.In addition to ADCY1, the mechanism(s) of other signaling pathways in TP need to be explored in future research.EA treatment may promote the recovery of TP model rat by regulating ADCY1 expression." @default.
- W4284712422 created "2022-07-08" @default.
- W4284712422 creator A5029708266 @default.
- W4284712422 creator A5035113720 @default.
- W4284712422 creator A5053200688 @default.
- W4284712422 creator A5055993561 @default.
- W4284712422 creator A5057170433 @default.
- W4284712422 creator A5083917350 @default.
- W4284712422 date "2022-07-01" @default.
- W4284712422 modified "2023-09-26" @default.
- W4284712422 title "Electroacupuncture Alleviates Thalamic Pain in Rats by Suppressing ADCY1 Protein Upregulation." @default.
- W4284712422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35793187" @default.
- W4284712422 hasPublicationYear "2022" @default.
- W4284712422 type Work @default.
- W4284712422 citedByCount "2" @default.
- W4284712422 countsByYear W42847124222022 @default.
- W4284712422 countsByYear W42847124222023 @default.
- W4284712422 crossrefType "journal-article" @default.
- W4284712422 hasAuthorship W4284712422A5029708266 @default.
- W4284712422 hasAuthorship W4284712422A5035113720 @default.
- W4284712422 hasAuthorship W4284712422A5053200688 @default.
- W4284712422 hasAuthorship W4284712422A5055993561 @default.
- W4284712422 hasAuthorship W4284712422A5057170433 @default.
- W4284712422 hasAuthorship W4284712422A5083917350 @default.
- W4284712422 hasConcept C104317684 @default.
- W4284712422 hasConcept C126322002 @default.
- W4284712422 hasConcept C126838900 @default.
- W4284712422 hasConcept C127561419 @default.
- W4284712422 hasConcept C142724271 @default.
- W4284712422 hasConcept C185592680 @default.
- W4284712422 hasConcept C1862650 @default.
- W4284712422 hasConcept C204787440 @default.
- W4284712422 hasConcept C2776202274 @default.
- W4284712422 hasConcept C2777107010 @default.
- W4284712422 hasConcept C2779246727 @default.
- W4284712422 hasConcept C2781118164 @default.
- W4284712422 hasConcept C3673659 @default.
- W4284712422 hasConcept C42219234 @default.
- W4284712422 hasConcept C55493867 @default.
- W4284712422 hasConcept C56837625 @default.
- W4284712422 hasConcept C71924100 @default.
- W4284712422 hasConceptScore W4284712422C104317684 @default.
- W4284712422 hasConceptScore W4284712422C126322002 @default.
- W4284712422 hasConceptScore W4284712422C126838900 @default.
- W4284712422 hasConceptScore W4284712422C127561419 @default.
- W4284712422 hasConceptScore W4284712422C142724271 @default.
- W4284712422 hasConceptScore W4284712422C185592680 @default.
- W4284712422 hasConceptScore W4284712422C1862650 @default.
- W4284712422 hasConceptScore W4284712422C204787440 @default.
- W4284712422 hasConceptScore W4284712422C2776202274 @default.
- W4284712422 hasConceptScore W4284712422C2777107010 @default.
- W4284712422 hasConceptScore W4284712422C2779246727 @default.
- W4284712422 hasConceptScore W4284712422C2781118164 @default.
- W4284712422 hasConceptScore W4284712422C3673659 @default.
- W4284712422 hasConceptScore W4284712422C42219234 @default.
- W4284712422 hasConceptScore W4284712422C55493867 @default.
- W4284712422 hasConceptScore W4284712422C56837625 @default.
- W4284712422 hasConceptScore W4284712422C71924100 @default.
- W4284712422 hasIssue "4" @default.
- W4284712422 hasLocation W42847124221 @default.
- W4284712422 hasOpenAccess W4284712422 @default.
- W4284712422 hasPrimaryLocation W42847124221 @default.
- W4284712422 hasRelatedWork W11610781 @default.
- W4284712422 hasRelatedWork W12685669 @default.
- W4284712422 hasRelatedWork W13013805 @default.
- W4284712422 hasRelatedWork W17194036 @default.
- W4284712422 hasRelatedWork W23610 @default.
- W4284712422 hasRelatedWork W3080829 @default.
- W4284712422 hasRelatedWork W3157600 @default.
- W4284712422 hasRelatedWork W7859077 @default.
- W4284712422 hasRelatedWork W8818755 @default.
- W4284712422 hasRelatedWork W880080 @default.
- W4284712422 hasVolume "25" @default.
- W4284712422 isParatext "false" @default.
- W4284712422 isRetracted "false" @default.
- W4284712422 workType "article" @default.