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• W4284879990 abstract "Diabetic nephropathy (DN) is one of the most important complications of diabetes mellitus (DM) and has become the second cause of end-stage renal disease (ESRD). This study intends to investigate the molecular mechanism of increased mitochondrial fission in podocytes under the effect of high glucose (HG), and to preliminarily study the role of mitochondrial fission factor (MFF)-mediated mitochondrial fission in podocyte injury of DN. In vitro studies, we found that HG induced increased mitochondrial fission and podocyte damage. At the same time MFF mRNA and protein levels was increased, suggesting that MFF was transcriptional upregulated under HG conditions. Consistent with this, in vivo studies found that mitochondrial fission was also significantly increased in podocytes of diabetic nephropathy mice, and MFF expression was up-regulated. Therefore, our study proves that mitochondrial fission increases in podocytes under DM both in vitro and in vivo, and the up-regulation of MFF expression may be one of the reasons for the increase of mitochondrial fission. After inhibiting the expression of MFF, the survival rate of podocytes was significantly decreased under HG conditions, suggesting that MFF may play a protective role in podocyte injury in DN." @default.
• W4284879990 created "2022-07-09" @default.
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• W4284879990 date "2022-10-01" @default.
• W4284879990 modified "2023-10-13" @default.
• W4284879990 title "The role of mitochondrial fission factor in podocyte injury in diabetic nephropathy" @default.
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• W4284879990 doi "https://doi.org/10.1016/j.bbrc.2022.07.019" @default.
• W4284879990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35932578" @default.
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