Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284880167> ?p ?o ?g. }
- W4284880167 endingPage "412" @default.
- W4284880167 startingPage "398" @default.
- W4284880167 abstract "Type I interferon (IFN-I) is a common biological molecule used for the treatment of viral diseases. However, the clinical antiviral efficacy of IFN-I needs to be greatly improved. In this study, IFN-I receptor 2 (IFNAR2) was revealed to undergo degradation at the protein level in cells treated with IFN-I for long periods of time. Further studies found a physical interaction between the E3 ubiquitin ligase midline-1 (MID1) and IFNAR2. As a consequence, MID1 induced both K48- and K63-linked polyubiquitination of IFNAR2, which promoted IFNAR2 protein degradation in a lysosome-dependent manner. Conversely, knockdown of MID1 largely restricted IFN-I-induced degradation of IFNAR2. Importantly, MID1 regulated the strength of IFN-I signalling and IFN-I-induced antiviral activity. These findings reveal a regulatory mechanism of IFNAR2 ubiquitination and protein stability in IFN-I signalling, which could provide a potential target for improving the antiviral efficacy of IFN-I." @default.
- W4284880167 created "2022-07-09" @default.
- W4284880167 creator A5007067690 @default.
- W4284880167 creator A5017066267 @default.
- W4284880167 creator A5017735710 @default.
- W4284880167 creator A5018743839 @default.
- W4284880167 creator A5020597164 @default.
- W4284880167 creator A5031404818 @default.
- W4284880167 creator A5039808218 @default.
- W4284880167 creator A5042241049 @default.
- W4284880167 creator A5044367029 @default.
- W4284880167 creator A5050157809 @default.
- W4284880167 creator A5054808938 @default.
- W4284880167 creator A5058049916 @default.
- W4284880167 creator A5058808630 @default.
- W4284880167 creator A5066433693 @default.
- W4284880167 creator A5077457004 @default.
- W4284880167 creator A5077901502 @default.
- W4284880167 creator A5084843344 @default.
- W4284880167 creator A5085731370 @default.
- W4284880167 creator A5085875811 @default.
- W4284880167 creator A5086434649 @default.
- W4284880167 creator A5087183170 @default.
- W4284880167 creator A5088549603 @default.
- W4284880167 date "2022-07-23" @default.
- W4284880167 modified "2023-10-11" @default.
- W4284880167 title "<scp>E3</scp> ubiquitin ligase <scp>MID1</scp> ubiquitinates and degrades <scp>type‐I</scp> interferon receptor 2" @default.
- W4284880167 cites W1524765091 @default.
- W4284880167 cites W1576464279 @default.
- W4284880167 cites W1967046363 @default.
- W4284880167 cites W1967475015 @default.
- W4284880167 cites W1979448464 @default.
- W4284880167 cites W1983859259 @default.
- W4284880167 cites W1994203138 @default.
- W4284880167 cites W1997538265 @default.
- W4284880167 cites W2009614729 @default.
- W4284880167 cites W2023399402 @default.
- W4284880167 cites W2030718808 @default.
- W4284880167 cites W2030739472 @default.
- W4284880167 cites W2031423498 @default.
- W4284880167 cites W2031913105 @default.
- W4284880167 cites W2035783366 @default.
- W4284880167 cites W2037348533 @default.
- W4284880167 cites W2040580977 @default.
- W4284880167 cites W2041194506 @default.
- W4284880167 cites W2048221101 @default.
- W4284880167 cites W2056618213 @default.
- W4284880167 cites W2066918407 @default.
- W4284880167 cites W2072286261 @default.
- W4284880167 cites W2075527727 @default.
- W4284880167 cites W2076198632 @default.
- W4284880167 cites W2088988430 @default.
- W4284880167 cites W2127421267 @default.
- W4284880167 cites W2127997174 @default.
- W4284880167 cites W2132173287 @default.
- W4284880167 cites W2135962129 @default.
- W4284880167 cites W2139714570 @default.
- W4284880167 cites W2148810559 @default.
- W4284880167 cites W2149330714 @default.
- W4284880167 cites W2163413830 @default.
- W4284880167 cites W2171759277 @default.
- W4284880167 cites W2318332039 @default.
- W4284880167 cites W2429989161 @default.
- W4284880167 cites W2484358566 @default.
- W4284880167 cites W2501805770 @default.
- W4284880167 cites W2553959872 @default.
- W4284880167 cites W2556737993 @default.
- W4284880167 cites W2604505695 @default.
- W4284880167 cites W2607063363 @default.
- W4284880167 cites W2741094809 @default.
- W4284880167 cites W2782429867 @default.
- W4284880167 cites W2803519813 @default.
- W4284880167 cites W2923380960 @default.
- W4284880167 cites W2937057287 @default.
- W4284880167 cites W2944826857 @default.
- W4284880167 cites W2994169676 @default.
- W4284880167 cites W2999659495 @default.
- W4284880167 cites W3004837376 @default.
- W4284880167 cites W3009440525 @default.
- W4284880167 cites W3015921112 @default.
- W4284880167 cites W3099496572 @default.
- W4284880167 cites W3125796414 @default.
- W4284880167 doi "https://doi.org/10.1111/imm.13544" @default.
- W4284880167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35794827" @default.
- W4284880167 hasPublicationYear "2022" @default.
- W4284880167 type Work @default.
- W4284880167 citedByCount "2" @default.
- W4284880167 countsByYear W42848801672023 @default.
- W4284880167 crossrefType "journal-article" @default.
- W4284880167 hasAuthorship W4284880167A5007067690 @default.
- W4284880167 hasAuthorship W4284880167A5017066267 @default.
- W4284880167 hasAuthorship W4284880167A5017735710 @default.
- W4284880167 hasAuthorship W4284880167A5018743839 @default.
- W4284880167 hasAuthorship W4284880167A5020597164 @default.
- W4284880167 hasAuthorship W4284880167A5031404818 @default.
- W4284880167 hasAuthorship W4284880167A5039808218 @default.
- W4284880167 hasAuthorship W4284880167A5042241049 @default.
- W4284880167 hasAuthorship W4284880167A5044367029 @default.