Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284884842> ?p ?o ?g. }
- W4284884842 endingPage "e202201497" @default.
- W4284884842 startingPage "e202201497" @default.
- W4284884842 abstract "Stanniocalcin-1 (STC1) is a hypocalcemic hormone originally identified in bony fishes. The mammalian homolog is found to be involved in inflammation and carcinogenesis, among other physiological functions. In this study, we used the TriCEPS-based ligand–receptor methodology to identify the putative binding proteins of human STC1 (hSTC1) in the human leukemia monocytic cell line, ThP-1. LC–MS/MS analysis of peptides from shortlisted hSTC1-binding proteins detected 32 peptides that belong to IGF2/MPRI. Surface plasmon resonance assay demonstrated that hSTC1 binds to immobilized IGF2R/MPRI with high affinity (10–20 nM) and capacity (Rmax 70–100%). The receptor binding data are comparable with those of (CREG) cellular repressor of E1A-stimulated gene a known ligand of IGF2R/MPRI, with Rmax of 75–80% and affinity values of 1–2 nM. The surface plasmon resonance competitive assays showed CREG competed with hSTC1 in binding to IGF2R/MPRI. The biological effects of hSTC1 on ThP-1 cells were demonstrated via IGF2R/MPRI to significantly reduce secreted levels of IL-1β. This is the first study to reveal the high-affinity binding of hSTC1 to the membrane receptor IGF2R/MPRI." @default.
- W4284884842 created "2022-07-09" @default.
- W4284884842 creator A5002836650 @default.
- W4284884842 creator A5028861489 @default.
- W4284884842 creator A5041047695 @default.
- W4284884842 creator A5051830599 @default.
- W4284884842 creator A5087990066 @default.
- W4284884842 date "2022-07-07" @default.
- W4284884842 modified "2023-10-17" @default.
- W4284884842 title "Identification and characterization of a membrane receptor that binds to human STC1" @default.
- W4284884842 cites W1481643052 @default.
- W4284884842 cites W1494097724 @default.
- W4284884842 cites W1894312995 @default.
- W4284884842 cites W1934957927 @default.
- W4284884842 cites W1964428238 @default.
- W4284884842 cites W1967470824 @default.
- W4284884842 cites W1968288019 @default.
- W4284884842 cites W1969680903 @default.
- W4284884842 cites W1971228457 @default.
- W4284884842 cites W1973525302 @default.
- W4284884842 cites W1978538506 @default.
- W4284884842 cites W1978748805 @default.
- W4284884842 cites W1983058200 @default.
- W4284884842 cites W1992426840 @default.
- W4284884842 cites W1995184255 @default.
- W4284884842 cites W2000229809 @default.
- W4284884842 cites W2003642703 @default.
- W4284884842 cites W2010798525 @default.
- W4284884842 cites W2011768923 @default.
- W4284884842 cites W2015157018 @default.
- W4284884842 cites W2017925004 @default.
- W4284884842 cites W2024966400 @default.
- W4284884842 cites W2025794637 @default.
- W4284884842 cites W2027999430 @default.
- W4284884842 cites W2032539570 @default.
- W4284884842 cites W2036771641 @default.
- W4284884842 cites W2045460249 @default.
- W4284884842 cites W2055635657 @default.
- W4284884842 cites W2062464820 @default.
- W4284884842 cites W2072501396 @default.
- W4284884842 cites W2087128098 @default.
- W4284884842 cites W2099029872 @default.
- W4284884842 cites W2106250184 @default.
- W4284884842 cites W2110783708 @default.
- W4284884842 cites W2136166312 @default.
- W4284884842 cites W2147432298 @default.
- W4284884842 cites W2147583711 @default.
- W4284884842 cites W2147691957 @default.
- W4284884842 cites W2150094179 @default.
- W4284884842 cites W2152869377 @default.
- W4284884842 cites W2158414994 @default.
- W4284884842 cites W2159502605 @default.
- W4284884842 cites W2160909976 @default.
- W4284884842 cites W2167390780 @default.
- W4284884842 cites W2169538725 @default.
- W4284884842 cites W2274718906 @default.
- W4284884842 cites W2805528464 @default.
- W4284884842 cites W3106898334 @default.
- W4284884842 cites W4205916292 @default.
- W4284884842 cites W4233018375 @default.
- W4284884842 cites W4237067893 @default.
- W4284884842 cites W4239149663 @default.
- W4284884842 cites W4240136522 @default.
- W4284884842 cites W4243324681 @default.
- W4284884842 doi "https://doi.org/10.26508/lsa.202201497" @default.
- W4284884842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35798563" @default.
- W4284884842 hasPublicationYear "2022" @default.
- W4284884842 type Work @default.
- W4284884842 citedByCount "0" @default.
- W4284884842 crossrefType "journal-article" @default.
- W4284884842 hasAuthorship W4284884842A5002836650 @default.
- W4284884842 hasAuthorship W4284884842A5028861489 @default.
- W4284884842 hasAuthorship W4284884842A5041047695 @default.
- W4284884842 hasAuthorship W4284884842A5051830599 @default.
- W4284884842 hasAuthorship W4284884842A5087990066 @default.
- W4284884842 hasBestOaLocation W42848848421 @default.
- W4284884842 hasConcept C106847996 @default.
- W4284884842 hasConcept C116569031 @default.
- W4284884842 hasConcept C153911025 @default.
- W4284884842 hasConcept C155672457 @default.
- W4284884842 hasConcept C170493617 @default.
- W4284884842 hasConcept C171250308 @default.
- W4284884842 hasConcept C185592680 @default.
- W4284884842 hasConcept C192562407 @default.
- W4284884842 hasConcept C55493867 @default.
- W4284884842 hasConcept C86803240 @default.
- W4284884842 hasConceptScore W4284884842C106847996 @default.
- W4284884842 hasConceptScore W4284884842C116569031 @default.
- W4284884842 hasConceptScore W4284884842C153911025 @default.
- W4284884842 hasConceptScore W4284884842C155672457 @default.
- W4284884842 hasConceptScore W4284884842C170493617 @default.
- W4284884842 hasConceptScore W4284884842C171250308 @default.
- W4284884842 hasConceptScore W4284884842C185592680 @default.
- W4284884842 hasConceptScore W4284884842C192562407 @default.
- W4284884842 hasConceptScore W4284884842C55493867 @default.
- W4284884842 hasConceptScore W4284884842C86803240 @default.
- W4284884842 hasIssue "11" @default.
- W4284884842 hasLocation W42848848421 @default.