Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284884859> ?p ?o ?g. }
- W4284884859 endingPage "3326" @default.
- W4284884859 startingPage "3326" @default.
- W4284884859 abstract "Recently, endoplasmic reticulum (ER) stress has been shown to influence tumor progression and immune cell function in the tumor microenvironment (TME). However, the underlying role of ER stress-related gene patterns in colorectal cancer (CRC) development remains unclear. We analyzed the ER stress-related gene patterns in 884 patients with CRC from the Gene Expression Omnibus database and evaluated the cell-infiltrating patterns in the TME. Two ER stress-related patterns were identified in patients with CRC that had distinct cell-infiltrating patterns in the TME and clinical characteristics. A risk score and nomogram based on 14 screened prognosis-correlated genes was built and validated to predict patient survival. Patients with a higher risk score were shown to have an unfavorable prognosis, and the risk score was associated with cell infiltration and drug sensitivity. Furthermore, spatial transcriptomics data were utilized to explore ER stress-related gene patterns in CRC tissues, and it was shown that ER stress phenotype involves in the formation of the immunosuppressive TME. This study demonstrated that ER stress-related gene patterns play a role in influencing the TME and predicting prognosis. These analyses of ER stress in the TME of CRC might deepen our understanding of CRC progression and immune escape and provide novel insights into therapeutic strategies." @default.
- W4284884859 created "2022-07-09" @default.
- W4284884859 creator A5000107458 @default.
- W4284884859 creator A5003433234 @default.
- W4284884859 creator A5005557287 @default.
- W4284884859 creator A5011877804 @default.
- W4284884859 creator A5021847587 @default.
- W4284884859 creator A5044882661 @default.
- W4284884859 creator A5069069039 @default.
- W4284884859 creator A5074350121 @default.
- W4284884859 creator A5078665082 @default.
- W4284884859 creator A5082325072 @default.
- W4284884859 creator A5090950891 @default.
- W4284884859 creator A5091357738 @default.
- W4284884859 date "2022-07-08" @default.
- W4284884859 modified "2023-09-28" @default.
- W4284884859 title "Identification of Endoplasmic Reticulum Stress-Related Subtypes, Infiltration Analysis of Tumor Microenvironment, and Construction of a Prognostic Model in Colorectal Cancer" @default.
- W4284884859 cites W1530495975 @default.
- W4284884859 cites W1561349380 @default.
- W4284884859 cites W1767508090 @default.
- W4284884859 cites W1934094702 @default.
- W4284884859 cites W1985987855 @default.
- W4284884859 cites W1988548899 @default.
- W4284884859 cites W1994993231 @default.
- W4284884859 cites W2007078899 @default.
- W4284884859 cites W2033278321 @default.
- W4284884859 cites W2035618305 @default.
- W4284884859 cites W2037911961 @default.
- W4284884859 cites W2053442171 @default.
- W4284884859 cites W2058785552 @default.
- W4284884859 cites W2074471441 @default.
- W4284884859 cites W2091415498 @default.
- W4284884859 cites W2095242372 @default.
- W4284884859 cites W2097995306 @default.
- W4284884859 cites W2099429776 @default.
- W4284884859 cites W2100347985 @default.
- W4284884859 cites W2106958893 @default.
- W4284884859 cites W2130430382 @default.
- W4284884859 cites W2136850043 @default.
- W4284884859 cites W2146512944 @default.
- W4284884859 cites W2159675211 @default.
- W4284884859 cites W2159707944 @default.
- W4284884859 cites W2162695817 @default.
- W4284884859 cites W2170866914 @default.
- W4284884859 cites W2433751364 @default.
- W4284884859 cites W2461952548 @default.
- W4284884859 cites W2488076079 @default.
- W4284884859 cites W2533508881 @default.
- W4284884859 cites W2561926137 @default.
- W4284884859 cites W2567668099 @default.
- W4284884859 cites W2600132724 @default.
- W4284884859 cites W2724339850 @default.
- W4284884859 cites W2738794221 @default.
- W4284884859 cites W2796582438 @default.
- W4284884859 cites W2866490332 @default.
- W4284884859 cites W2887577080 @default.
- W4284884859 cites W2900569176 @default.
- W4284884859 cites W2910787601 @default.
- W4284884859 cites W2920863623 @default.
- W4284884859 cites W2944778679 @default.
- W4284884859 cites W2947891482 @default.
- W4284884859 cites W2949273159 @default.
- W4284884859 cites W2961584252 @default.
- W4284884859 cites W2988704237 @default.
- W4284884859 cites W2992289032 @default.
- W4284884859 cites W3015222397 @default.
- W4284884859 cites W3015575990 @default.
- W4284884859 cites W3030834164 @default.
- W4284884859 cites W3031767666 @default.
- W4284884859 cites W3039484069 @default.
- W4284884859 cites W3082805696 @default.
- W4284884859 cites W3099817120 @default.
- W4284884859 cites W3167767211 @default.
- W4284884859 cites W3177306556 @default.
- W4284884859 cites W3213528727 @default.
- W4284884859 cites W4225508609 @default.
- W4284884859 cites W4280560903 @default.
- W4284884859 doi "https://doi.org/10.3390/cancers14143326" @default.
- W4284884859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35884393" @default.
- W4284884859 hasPublicationYear "2022" @default.
- W4284884859 type Work @default.
- W4284884859 citedByCount "1" @default.
- W4284884859 countsByYear W42848848592023 @default.
- W4284884859 crossrefType "journal-article" @default.
- W4284884859 hasAuthorship W4284884859A5000107458 @default.
- W4284884859 hasAuthorship W4284884859A5003433234 @default.
- W4284884859 hasAuthorship W4284884859A5005557287 @default.
- W4284884859 hasAuthorship W4284884859A5011877804 @default.
- W4284884859 hasAuthorship W4284884859A5021847587 @default.
- W4284884859 hasAuthorship W4284884859A5044882661 @default.
- W4284884859 hasAuthorship W4284884859A5069069039 @default.
- W4284884859 hasAuthorship W4284884859A5074350121 @default.
- W4284884859 hasAuthorship W4284884859A5078665082 @default.
- W4284884859 hasAuthorship W4284884859A5082325072 @default.
- W4284884859 hasAuthorship W4284884859A5090950891 @default.
- W4284884859 hasAuthorship W4284884859A5091357738 @default.
- W4284884859 hasBestOaLocation W42848848591 @default.
- W4284884859 hasConcept C104317684 @default.