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• W4284885348 abstract "Liquid-liquid phase separation (LLPS) is a novel principle for explaining the precise spatial and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids into micron-scale, liquid-like, membraneless bodies with specific functions, which were recently termed biomolecular condensates. Biomolecular condensates are executors underlying the intracellular spatiotemporal coordination of various biological activities, including chromatin organization, genomic stability, DNA damage response and repair, transcription, and signal transduction. Dysregulation of these cellular processes is a key event in the initiation and/or evolution of cancer, and emerging evidence has linked the formation and regulation of LLPS to malignant transformations in tumor biology. In this review, we comprehensively summarize the detailed mechanisms of biomolecular condensate formation and biophysical function and review the recent major advances toward elucidating the multiple mechanisms involved in cancer cell pathology driven by aberrant LLPS. In addition, we discuss the therapeutic perspectives of LLPS in cancer research and the most recently developed drug candidates targeting LLPS modulation that can be used to combat tumorigenesis." @default.
• W4284885348 created "2022-07-09" @default.
• W4284885348 creator A5010647321 @default.
• W4284885348 creator A5032653173 @default.
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• W4284885348 creator A5078370650 @default.
• W4284885348 creator A5078554779 @default.
• W4284885348 date "2022-07-08" @default.
• W4284885348 modified "2023-10-15" @default.
• W4284885348 title "Liquid–liquid phase separation in tumor biology" @default.
• W4284885348 cites W123886882 @default.
• W4284885348 cites W1488181101 @default.
• W4284885348 cites W1557670864 @default.
• W4284885348 cites W1559117436 @default.
• W4284885348 cites W1600373583 @default.
• W4284885348 cites W1674292201 @default.
• W4284885348 cites W169584480 @default.
• W4284885348 cites W1854281301 @default.
• W4284885348 cites W1896451102 @default.
• W4284885348 cites W1915701790 @default.
• W4284885348 cites W1935389499 @default.
• W4284885348 cites W1936657395 @default.
• W4284885348 cites W1938908576 @default.
• W4284885348 cites W1952608303 @default.
• W4284885348 cites W1964605487 @default.
• W4284885348 cites W1965912619 @default.
• W4284885348 cites W1966841369 @default.
• W4284885348 cites W1967058595 @default.
• W4284885348 cites W1968075505 @default.
• W4284885348 cites W1969161156 @default.
• W4284885348 cites W1969466735 @default.
• W4284885348 cites W1971108880 @default.
• W4284885348 cites W1973522156 @default.
• W4284885348 cites W1973549360 @default.
• W4284885348 cites W1978981036 @default.
• W4284885348 cites W1981700185 @default.
• W4284885348 cites W1984714342 @default.
• W4284885348 cites W1987844291 @default.
• W4284885348 cites W1993084790 @default.
• W4284885348 cites W1993275211 @default.
• W4284885348 cites W1994115507 @default.
• W4284885348 cites W1994847090 @default.
• W4284885348 cites W1995068068 @default.
• W4284885348 cites W1995657253 @default.
• W4284885348 cites W1996811911 @default.
• W4284885348 cites W1997342202 @default.
• W4284885348 cites W2002014572 @default.
• W4284885348 cites W2002395443 @default.
• W4284885348 cites W2004966039 @default.
• W4284885348 cites W2005918656 @default.
• W4284885348 cites W2006703184 @default.
• W4284885348 cites W2006719016 @default.
• W4284885348 cites W2009849037 @default.
• W4284885348 cites W2010453590 @default.
• W4284885348 cites W2010882280 @default.
• W4284885348 cites W2011175794 @default.
• W4284885348 cites W2012857662 @default.
• W4284885348 cites W2015197144 @default.
• W4284885348 cites W2020746805 @default.
• W4284885348 cites W2023011946 @default.
• W4284885348 cites W2023344075 @default.
• W4284885348 cites W2025059119 @default.
• W4284885348 cites W2025277638 @default.
• W4284885348 cites W2026226960 @default.
• W4284885348 cites W2028878627 @default.
• W4284885348 cites W2032192339 @default.
• W4284885348 cites W2034269086 @default.
• W4284885348 cites W2041535798 @default.
• W4284885348 cites W2049197710 @default.
• W4284885348 cites W2054077521 @default.
• W4284885348 cites W2054352933 @default.
• W4284885348 cites W2054923018 @default.
• W4284885348 cites W2055502725 @default.
• W4284885348 cites W2057257265 @default.
• W4284885348 cites W2058011778 @default.
• W4284885348 cites W2058142370 @default.
• W4284885348 cites W2060484997 @default.
• W4284885348 cites W2060955969 @default.
• W4284885348 cites W2070660722 @default.
• W4284885348 cites W2073224213 @default.
• W4284885348 cites W2073910361 @default.
• W4284885348 cites W2074111784 @default.
• W4284885348 cites W2076142854 @default.
• W4284885348 cites W2077000240 @default.
• W4284885348 cites W2082414039 @default.
• W4284885348 cites W2085106808 @default.
• W4284885348 cites W2085978470 @default.
• W4284885348 cites W2086896046 @default.
• W4284885348 cites W2087351768 @default.
• W4284885348 cites W2088509899 @default.
• W4284885348 cites W2090097708 @default.
• W4284885348 cites W2091405727 @default.
• W4284885348 cites W2093140735 @default.
• W4284885348 cites W2098692163 @default.
• W4284885348 cites W2100163552 @default.
• W4284885348 cites W2100383597 @default.
• W4284885348 cites W2102025585 @default.
• W4284885348 cites W2102898524 @default.

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