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- W4284885444 endingPage "1303" @default.
- W4284885444 startingPage "1285" @default.
- W4284885444 abstract "Candida species are the most commonly isolated opportunistic fungal pathogens in humans. Candida albicans causes most of the diagnosed infections, closely followed by Candida glabrata. C. albicans is well studied, and many genes have been shown to be important for infection and colonization of the host. It is however less clear how C. glabrata infects the host. With the help of fungal RNA enrichment, we here investigated for the first time the transcriptomic profile of C. glabrata during urinary tract infection (UTI) in mice. In the UTI model, bladders and kidneys are major target organs and therefore fungal transcriptomes were addressed in these organs. Our results showed that, next to adhesins and proteases, nitrogen metabolism and regulation play a vital role during C. glabrata UTI. Genes involved in nitrogen metabolism were upregulated and among them we show that DUR1,2 (urea amidolyase) and GAP1 (amino acid permease) were important for virulence. Furthermore, we confirmed the importance of the glyoxylate cycle in the host and identified MLS1 (malate synthase) as an important gene necessary for C. glabrata virulence. In conclusion, our study shows with the support of in vivo transcriptomics how C. glabrata adapts to host conditions." @default.
- W4284885444 created "2022-07-09" @default.
- W4284885444 creator A5018233670 @default.
- W4284885444 creator A5020062167 @default.
- W4284885444 creator A5062637687 @default.
- W4284885444 creator A5072595038 @default.
- W4284885444 date "2022-07-31" @default.
- W4284885444 modified "2023-10-01" @default.
- W4284885444 title "Using <i>in vivo</i> transcriptomics and RNA enrichment to identify genes involved in virulence of <i>Candida glabrata</i>" @default.
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