FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284885870> ?p ?o ?g. }

• W4284885870 abstract "Past studies described interactions between normal megakaryocytes, the platelet precursors, and bone cell precursors in the bone marrow. This relationship has also been studied in context of various mutations associated with increased number of megakaryocytes. The current study is the first to examine the effects of megakaryocytes from transgenic mice carrying the most common mutation that causes primary myelofibrosis (PMF) in humans (JAK2 V617F ) on bone cell differentiation. Organ level assessments of mice using micro-computed tomography showed decreased bone volume in JAK2 V617F males, compared to matching controls. Tissue level histology revealed increased deposition of osteoid (bone matrix prior mineralization) in these mutated mice, suggesting an effect on osteoblast differentiation. Mechanistic studies using a megakaryocyte-osteoblast co-culture system, showed that both wild type or JAK2 V617F megakaryocytes derived from male mice inhibited osteoblast differentiation, but JAK2 V617F cells exerted a more significant inhibitory effect. A mouse mRNA osteogenesis array showed increased expression of Noggin, Chordin, Alpha-2-HS-glycoprotein, Collagen type IV alpha 1 and Collagen type XIV alpha 1 (mostly known to inhibit bone differentiation), and decreased expression of alkaline phosphatase, Vascular cell adhesion molecule 1, Sclerostin, Distal-less homeobox 5 and Collagen type III alpha 1 (associated with osteogenesis) in JAK2 V617F megakaryocytes, compared to controls. This suggested that the mutation re-programs megakaryocytes to express a cluster of genes, which together could orchestrate greater suppression of osteogenesis in male mice. These findings provide mechanistic insight into the effect of JAK2 V617F mutation on bone, encouraging future examination of patients with this or other PMF-inducing mutations." @default.
• W4284885870 created "2022-07-09" @default.
• W4284885870 creator A5001398848 @default.
• W4284885870 creator A5016693607 @default.
• W4284885870 creator A5017237763 @default.
• W4284885870 creator A5063351158 @default.
• W4284885870 date "2022-07-08" @default.
• W4284885870 modified "2023-10-17" @default.
• W4284885870 title "Inhibition of Osteoblast Differentiation by JAK2V617F Megakaryocytes Derived From Male Mice With Primary Myelofibrosis" @default.
• W4284885870 cites W1494856590 @default.
• W4284885870 cites W1644692312 @default.
• W4284885870 cites W1662539477 @default.
• W4284885870 cites W1905985436 @default.
• W4284885870 cites W1968755117 @default.
• W4284885870 cites W1969176838 @default.
• W4284885870 cites W1969726379 @default.
• W4284885870 cites W1970751513 @default.
• W4284885870 cites W1984706329 @default.
• W4284885870 cites W1990019150 @default.
• W4284885870 cites W1992929473 @default.
• W4284885870 cites W1993080305 @default.
• W4284885870 cites W1993186363 @default.
• W4284885870 cites W1994703283 @default.
• W4284885870 cites W1994960912 @default.
• W4284885870 cites W2001189096 @default.
• W4284885870 cites W2009241321 @default.
• W4284885870 cites W2015941386 @default.
• W4284885870 cites W2020007020 @default.
• W4284885870 cites W2029318743 @default.
• W4284885870 cites W2030811264 @default.
• W4284885870 cites W2039815807 @default.
• W4284885870 cites W2042095186 @default.
• W4284885870 cites W2042409961 @default.
• W4284885870 cites W2047949563 @default.
• W4284885870 cites W2052047252 @default.
• W4284885870 cites W2075520774 @default.
• W4284885870 cites W2081896745 @default.
• W4284885870 cites W2088012334 @default.
• W4284885870 cites W2088360757 @default.
• W4284885870 cites W2088398635 @default.
• W4284885870 cites W2093228291 @default.
• W4284885870 cites W2106730339 @default.
• W4284885870 cites W2110924026 @default.
• W4284885870 cites W2116325227 @default.
• W4284885870 cites W2144525489 @default.
• W4284885870 cites W2146813459 @default.
• W4284885870 cites W2161157411 @default.
• W4284885870 cites W2169422563 @default.
• W4284885870 cites W2291337024 @default.
• W4284885870 cites W2550997078 @default.
• W4284885870 cites W2569838197 @default.
• W4284885870 cites W2602592835 @default.
• W4284885870 cites W26862222 @default.
• W4284885870 cites W2737703356 @default.
• W4284885870 cites W2748988165 @default.
• W4284885870 cites W2756360505 @default.
• W4284885870 cites W2794978485 @default.
• W4284885870 cites W2796031506 @default.
• W4284885870 cites W2804418334 @default.
• W4284885870 cites W2917495513 @default.
• W4284885870 cites W2980830065 @default.
• W4284885870 cites W2990073109 @default.
• W4284885870 cites W3004131968 @default.
• W4284885870 cites W3005098044 @default.
• W4284885870 cites W3006157754 @default.
• W4284885870 cites W3033932089 @default.
• W4284885870 cites W3081327676 @default.
• W4284885870 cites W3092292917 @default.
• W4284885870 cites W3105658552 @default.
• W4284885870 cites W3120229701 @default.
• W4284885870 cites W3193783304 @default.
• W4284885870 cites W348964253 @default.
• W4284885870 cites W4200393847 @default.
• W4284885870 cites W4226111216 @default.
• W4284885870 cites W4251897205 @default.
• W4284885870 doi "https://doi.org/10.3389/fonc.2022.929498" @default.
• W4284885870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35880162" @default.
• W4284885870 hasPublicationYear "2022" @default.
• W4284885870 type Work @default.
• W4284885870 citedByCount "1" @default.
• W4284885870 countsByYear W42848858702023 @default.
• W4284885870 crossrefType "journal-article" @default.
• W4284885870 hasAuthorship W4284885870A5001398848 @default.
• W4284885870 hasAuthorship W4284885870A5016693607 @default.
• W4284885870 hasAuthorship W4284885870A5017237763 @default.
• W4284885870 hasAuthorship W4284885870A5063351158 @default.
• W4284885870 hasBestOaLocation W42848858701 @default.
• W4284885870 hasConcept C104317684 @default.
• W4284885870 hasConcept C109159458 @default.
• W4284885870 hasConcept C126322002 @default.
• W4284885870 hasConcept C134018914 @default.
• W4284885870 hasConcept C148738053 @default.
• W4284885870 hasConcept C160160445 @default.
• W4284885870 hasConcept C181199279 @default.
• W4284885870 hasConcept C185592680 @default.
• W4284885870 hasConcept C202751555 @default.
• W4284885870 hasConcept C203014093 @default.
• W4284885870 hasConcept C2777918643 @default.
• W4284885870 hasConcept C2778260815 @default.
• W4284885870 hasConcept C2778761762 @default.

• next