FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4284889061> ?p ?o ?g. }

• W4284889061 endingPage "1635" @default.
• W4284889061 startingPage "1635" @default.
• W4284889061 abstract "Nanoparticles (NPs) can enable delivery of a drug to a targeted tissue. Previous studies have shown that an NP utilizing an adipose targeting sequence (ATS) peptide in conjunction with a drug can selectively deliver the drug to mouse adipose tissues, using the prohibitin protein expressed in adipose tissue as the target of the ATS. Adipose tissue is a major source of the adipokine chemerin, a prohypertensive protein. Liver-derived chemerin, the largest source of circulating chemerin, is biologically inactive in blood pressure regulation. Our goal is to understand if chemerin produced in adipose tissue contributes to blood pressure/hypertension. We hypothesize the ATS drug delivery system could be used specifically to reduce the levels of adipose tissue-derived chemerin. We created an NP consisting of an antisense oligonucleotide (ASO) against chemerin and a FITC-labeled ATS with a nine arginine sequence (ATS9R). In vitro studies showed that the ASO is functional when incorporated into an NP with ATS9R as it reduced chemerin mRNA expression in isolated epidydimal (Epi) and retroperitoneal (RP) fat adipocytes from Dahl SS rats. This same NP reduced chemerin in isolated whole fats. However, this NP was unable to selectively deliver the ASO to adipose tissue in vivo; liver delivery was dominant. Varying NP doses, administration route, and the concentration of components constituting the NP showed no improvement in ASO delivery to fats vs. the liver. Further studies are therefore needed to develop the ATS9R system to deliver an ASO to adipose beds in rats." @default.
• W4284889061 created "2022-07-09" @default.
• W4284889061 creator A5021842828 @default.
• W4284889061 creator A5028539103 @default.
• W4284889061 creator A5031102353 @default.
• W4284889061 creator A5036076411 @default.
• W4284889061 creator A5088983831 @default.
• W4284889061 date "2022-07-07" @default.
• W4284889061 modified "2023-09-30" @default.
• W4284889061 title "Divergence of Chemerin Reduction by an ATS9R Nanoparticle Targeting Adipose Tissue In Vitro vs. In Vivo in the Rat" @default.
• W4284889061 cites W1506101317 @default.
• W4284889061 cites W1639017051 @default.
• W4284889061 cites W1787941532 @default.
• W4284889061 cites W1845172926 @default.
• W4284889061 cites W1872757830 @default.
• W4284889061 cites W1969157495 @default.
• W4284889061 cites W1981439401 @default.
• W4284889061 cites W1998641894 @default.
• W4284889061 cites W2003790559 @default.
• W4284889061 cites W2018581697 @default.
• W4284889061 cites W2022903909 @default.
• W4284889061 cites W2038247085 @default.
• W4284889061 cites W2055538921 @default.
• W4284889061 cites W2064070725 @default.
• W4284889061 cites W2064655913 @default.
• W4284889061 cites W2074116165 @default.
• W4284889061 cites W2086121170 @default.
• W4284889061 cites W2088112872 @default.
• W4284889061 cites W2092566647 @default.
• W4284889061 cites W2106163955 @default.
• W4284889061 cites W2108560778 @default.
• W4284889061 cites W2119773094 @default.
• W4284889061 cites W2140444503 @default.
• W4284889061 cites W2142170772 @default.
• W4284889061 cites W2151009383 @default.
• W4284889061 cites W2563642244 @default.
• W4284889061 cites W2581670579 @default.
• W4284889061 cites W2624604453 @default.
• W4284889061 cites W2735376054 @default.
• W4284889061 cites W2756787254 @default.
• W4284889061 cites W2768267412 @default.
• W4284889061 cites W2791666741 @default.
• W4284889061 cites W2808271704 @default.
• W4284889061 cites W2893673243 @default.
• W4284889061 cites W2895977984 @default.
• W4284889061 cites W2907592805 @default.
• W4284889061 cites W2913157545 @default.
• W4284889061 cites W2919048656 @default.
• W4284889061 cites W2980072665 @default.
• W4284889061 cites W2985892902 @default.
• W4284889061 cites W3028793976 @default.
• W4284889061 cites W3092478077 @default.
• W4284889061 cites W3128959077 @default.
• W4284889061 cites W31347067 @default.
• W4284889061 cites W3184729959 @default.
• W4284889061 cites W3209802719 @default.
• W4284889061 cites W815763697 @default.
• W4284889061 doi "https://doi.org/10.3390/biomedicines10071635" @default.
• W4284889061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35884940" @default.
• W4284889061 hasPublicationYear "2022" @default.
• W4284889061 type Work @default.
• W4284889061 citedByCount "1" @default.
• W4284889061 countsByYear W42848890612023 @default.
• W4284889061 crossrefType "journal-article" @default.
• W4284889061 hasAuthorship W4284889061A5021842828 @default.
• W4284889061 hasAuthorship W4284889061A5028539103 @default.
• W4284889061 hasAuthorship W4284889061A5031102353 @default.
• W4284889061 hasAuthorship W4284889061A5036076411 @default.
• W4284889061 hasAuthorship W4284889061A5088983831 @default.
• W4284889061 hasBestOaLocation W42848890611 @default.
• W4284889061 hasConcept C126322002 @default.
• W4284889061 hasConcept C134018914 @default.
• W4284889061 hasConcept C150903083 @default.
• W4284889061 hasConcept C151955695 @default.
• W4284889061 hasConcept C171089720 @default.
• W4284889061 hasConcept C185592680 @default.
• W4284889061 hasConcept C194832188 @default.
• W4284889061 hasConcept C199901988 @default.
• W4284889061 hasConcept C207001950 @default.
• W4284889061 hasConcept C2777391703 @default.
• W4284889061 hasConcept C555293320 @default.
• W4284889061 hasConcept C71924100 @default.
• W4284889061 hasConcept C86803240 @default.
• W4284889061 hasConcept C98274493 @default.
• W4284889061 hasConceptScore W4284889061C126322002 @default.
• W4284889061 hasConceptScore W4284889061C134018914 @default.
• W4284889061 hasConceptScore W4284889061C150903083 @default.
• W4284889061 hasConceptScore W4284889061C151955695 @default.
• W4284889061 hasConceptScore W4284889061C171089720 @default.
• W4284889061 hasConceptScore W4284889061C185592680 @default.
• W4284889061 hasConceptScore W4284889061C194832188 @default.
• W4284889061 hasConceptScore W4284889061C199901988 @default.
• W4284889061 hasConceptScore W4284889061C207001950 @default.
• W4284889061 hasConceptScore W4284889061C2777391703 @default.
• W4284889061 hasConceptScore W4284889061C555293320 @default.
• W4284889061 hasConceptScore W4284889061C71924100 @default.
• W4284889061 hasConceptScore W4284889061C86803240 @default.
• W4284889061 hasConceptScore W4284889061C98274493 @default.

• next