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• W4284893313 abstract "Abstract During follicular development, a series of key events such as follicular recruitment and selection are crucially governed by strict complex regulation. However, its molecular mechanisms remain obscure. To identify the dominant genes controlling chicken follicular development, the small white follicle (SWF), the small yellow follicle (SYF), and the large yellow follicle (LYF) in different laying stages (W22, W31, W51) were collected for RNA sequencing and bioinformatics analysis. There were 1866, 1211, and 1515 differentially expressed genes (DEGs) between SWF and SYF in W22, W31, and W51, respectively. 4021, 2295, and 2902 DEGs were respectively identified between SYF and LYF in W22, W31, and W51. 5618, 4016, and 4809 DEGs were respectively identified between SWF and LYF in W22, W31, and W51. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that extracellular matrix, extracellular region, extracellular region part, ECM-receptor interaction, collagen extracellular matrix, and collagen trimer were significantly enriched ( P < 0.05). Protein–protein interaction analysis revealed that COL4A2 , COL1A2 , COL4A1 , COL5A2 , COL12A1 , ELN , ALB , and MMP10 might be key candidate genes for follicular development in chicken. The current study identified dominant genes and pathways contributing to our understanding of chicken follicular development." @default.
• W4284893313 created "2022-07-09" @default.
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• W4284893313 date "2022-07-07" @default.
• W4284893313 modified "2023-10-09" @default.
• W4284893313 title "Grade follicles transcriptional profiling analysis in different laying stages in chicken" @default.
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• W4284893313 doi "https://doi.org/10.1186/s12864-022-08728-w" @default.
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