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• W4284896074 abstract "Abstract Age-related changes in immune cell composition and functionality are associated with multimorbidity and mortality. However, many centenarians delay the onset of aging-related disease suggesting the presence of elite immunity that remains highly functional at extreme old age. To identify immune-specific patterns of aging and extreme human longevity, we analyzed novel single cell profiles from the peripheral blood mononuclear cells (PBMCs) of 7 centenarians (mean age 106) and publicly available single cell RNA-sequencing (scRNA-seq) datasets that included an additional 7 centenarians as well as 52 people at younger ages (20-89 years). The analysis confirmed known shifts in the ratio of lymphocytes to myeloid cells, and noncytotoxic to cytotoxic cell distributions with aging, but also identified significant shifts from CD4 + T cell to B cell populations in centenarians suggesting a history of exposure to natural and environmental immunogens. Our transcriptional analysis identified cell type signatures specific to exceptional longevity that included genes with age-related changes (e.g., increased expression of STK17A , a gene known to be involved in DNA damage response ) as well as genes expressed uniquely in centenarians’ PBMCs (e.g., S100A4 , part of the S100 protein family studied in age-related disease and connected to longevity and metabolic regulation ) . Collectively, these data suggest that centenarians harbor unique, highly functional immune systems that have successfully adapted to a history of insults allowing for the achievement of exceptional longevity." @default.
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• W4284896074 date "2022-07-07" @default.
• W4284896074 modified "2023-10-18" @default.
• W4284896074 title "Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity" @default.
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• W4284896074 doi "https://doi.org/10.1101/2022.07.06.498968" @default.
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